Dr. Thomas Burke

Ph.D.

Interests

The development of new approaches to environmental health surveillance, and the application of health risk assessment to public policy.

Titles

Professor and Associate Chair at The Johns Hopkins Bloomberg School of Public Health, Department of Health Policy and Management
Joint Appointments in the Department of Environmental Health Sciences and the School of Medicine Department of Oncology
Director of the Johns Hopkins Center for Excellence in Environmental Public Health Tracking and the Center for Excellence in Environmental Health Practice.
Co-Director of the Johns Hopkins Risk Sciences and Public Policy Institute

Schools\Degrees

Ph.D., epidemiology, University of Pennsylvania M.P.H., University of Texas

Research Summary

Dr. Burke’s research interests include environmental epidemiology, the evaluation of community exposures to environmental pollutants, the assessment and communication of environmental risks, and the application of epidemiology and health-risk assessment to public policy. He is a principal investigator for the Pew Environmental Health Commission-aimed at revitalizing the national infrastructure for environmental health. Dr. Burke is the chair of the Advisory Committee to the National Center for Environmental Health of the Centers for Disease Control. He is particularly interested in health and environment in the cities.

Journal Citations

Angerer, J.; Bird, M.G.; Burke, T.A.; Doerrer, N.G.; Needham, L.; Robison, S.H.; Sheldon, L.; Zenick, H. Strategic biomonitoring initiatives: moving the science forward. Toxicol Sci. 2006 Sep;93(1):3-10.

Gallicchio, L.; Kouzis, A.; Genkinger, J.M.; Burke, A.E.; Hoffman, S.C.; Diener-West, M.; Helzlsouer, K.J.; Comstock, G.W.; Alberg, A.J. Active cigarette smoking, household passive smoke exposure, and the risk of developing pancreatic cancer. Preventive medicine. 2006 Mar;42(3):200-205.

Herren, T.; Burke, T.A.; Das, R.; Plow, E.F. Identification of histone H2B as a regulated plasminogen receptor. Biochemistry. 2006 Aug 8;45(31):9463-9474.

Small, E.J.; Carducci, M.A.; Burke, J.M.; Rodriguez, R.; Fong, L.; van Ummersen, L.; Yu, D.C.; Aimi, J.; Ando, D.; Working, P.; Kirn, D.; Wilding, G. A phase I trial of intravenous CG7870, a replication-selective, prostate-specific antigen-targeted oncolytic adenovirus, for the treatment of hormone-refractory, metastatic prostate cancer. Mol Ther. 2006 Jul;14(1):107-117.

Gallicchio, L.; Visvanathan, K.; Burke, A.; Hoffman, S.C.; Helzlsouer, K.J. Nonsteroidal anti-inflammatory drugs and the risk of developing breast cancer in a population-based prospective cohort study in Washington County, MD. Int J Cancer. 2007 Jul 1;121(1):211-215.

Rohrmann, S.; Genkinger, J.M.; Burke, A.; Helzlsouer, K.J.; Comstock, G.W.; Alberg, A.J.; Platz, E.A. Smoking and risk of fatal prostate cancer in a prospective U.S. study. Urology. 2007 Apr;69(4):721-725.

Laheru, D.; Lutz, E.; Burke, J.; Biedrzycki, B.; Solt, S.; Onners, B.; Tartakovsky, I.; Nemunaitis, J.; Le, D.; Sugar, E.; Hege, K.; Jaffee, E. Allogeneic granulocyte macrophage colony-stimulating factor-secreting tumor immunotherapy alone or in sequence with cyclophosphamide for metastatic pancreatic cancer: a pilot study of safety, feasibility, and immune activation. Clin Cancer Res. 2008 Mar 1;14(5):1455-1463.

Resnick, B.; Zablotsky, J.; Nachman, K.; Burke, T. Examining the front lines of local environmental public health practice: a Maryland case study. J Public Health Manag Pract. 2008 Jan-Feb;14(1):42-50.

Althoff, K.N.; Paul, P.; Burke, A.E.; Viscidi, R.; Sangaramoorthy, M.; Gravitt, P.E. Correlates of cervicovaginal human papillomavirus detection in perimenopausal women. J Womens Health (Larchmt). 2009 Sep;18(9):1341-1346.

Resnick, B.A.; Zablotsky, J.; Burke, T.A. Protecting and promoting the nation's health: the environmental public health workforce as a critical component. J Public Health Manag Pract. 2009 Nov;15(6 Suppl):S40-45.

Resnick, B.A.; Zablotsky, J.; Janus, E.R.; Maggy, B.; Burke, T.A. An examination of environmental public health organizational and workforce configurations in the Northeast/Mid-Atlantic United States: how do we determine if these configurations impact performance? J Public Health Manag Pract. 2009 Nov-Dec;15(6):509-517.

Siddiq, A.; Aminova, L.R.; Troy, C.M.; Suh, K.; Messer, Z.; Semenza, G.L.; Ratan, R.R. Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways. J Neurosci. 2009 Jul 8;29(27):8828-8838.

Uscher-Pines, L.; Vernick, J.S.; Curriero, F.; Lieberman, R.; Burke, T.A. Disaster-related injuries in the period of recovery: the effect of prolonged displacement on risk of injury in older adults. The Journal of trauma. 2009 Oct;67(4):834-840.

White, R.H.; Cote, I.; Zeise, L.; Fox, M.; Dominici, F.; Burke, T.A.; White, P.D.; Hattis, D.B.; Samet, J.M. State-of-the-science workshop report: issues and approaches in low-dose-response extrapolation for environmental health risk assessment. Environ Health Perspect. 2009 Feb;117(2):283-287.

Burke, K.P.; Cox, A.L. Hepatitis C virus
evasion of adaptive immune responses: a model for viral persistence. Immunol Res. 2010 Jul;47(1-3):216-227.

Chung, C.H.; Aulino, J.; Muldowney, N.J.; Hatakeyama, H.; Baumann, J.; Burkey, B.; Netterville, J.; Sinard, R.; Yarbrough, W.G.; Cmelak, A.J.; Slebos, R.J.; Shyr, Y.; Parker, J.; Gilbert, J.; Murphy, B.A. Nuclear factor-kappa B pathway and response in a phase II trial of bortezomib and docetaxel in patients with recurrent and/or metastatic head and neck squamous cell carcinoma. Ann Oncol. 2010 Apr;21(4):864-870.

Chung, C.H.; Pohlmann, P.R.; Rothenberg, M.L.; Burkey, B.B.; Parker, J.; Palka, K.; Aulino, J.; Puzanov, I.; Murphy, B. Insulin-like growth factor-1 receptor inhibitor, AMG-479, in cetuximab-refractory head and neck squamous cell carcinoma. Head Neck. 2010 Jul 22.

Fox, M.; Curriero, F.; Kulbicki, K.; Resnick, B.; Burke, T. Evaluating the community health legacy of WWI chemical weapons testing. J Community Health. 2010 Feb;35(1):93-103.

Hudson, T.J.; Anderson, W.; Artez, A.; Barker, A.D.; Bell, C.; Bernabe, R.R.; Bhan, M.K.; Calvo, F.; Eerola, I.; Gerhard, D.S.; Guttmacher, A.; Guyer, M.; Hemsley, F.M.; Jennings, J.L.; Kerr, D.; Klatt, P.; Kolar, P.; Kusada, J.; Lane, D.P.; Laplace, F.; Youyong, L.; Nettekoven, G.; Ozenberger, B.; Peterson, J.; Rao, T.S.; Remacle, J.; Schafer, A.J.; Shibata, T.; Stratton, M.R.; Vockley, J.G.; Watanabe, K.; Yang, H.; Yuen, M.M.; Knoppers, B.M.; Bobrow, M.; Cambon-Thomsen, A.; Dressler, L.G.; Dyke, S.O.; Joly, Y.; Kato, K.; Kennedy, K.L.; Nicolas, P.; Parker, M.J.; Rial-Sebbag, E.; Romeo-Casabona, C.M.; Shaw, K.M.; Wallace, S.; Wiesner, G.L.; Zeps, N.; Lichter, P.; Biankin, A.V.; Chabannon, C.; Chin, L.; Clement, B.; de Alava, E.; Degos, F.; Ferguson, M.L.; Geary, P.; Hayes, D.N.; Johns, A.L.; Kasprzyk, A.; Nakagawa, H.; Penny, R.; Piris, M.A.; Sarin, R.; Scarpa, A.; van de Vijver, M.; Futreal, P.A.; Aburatani, H.; Bayes, M.; Botwell, D.D.; Campbell, P.J.; Estivill, X.; Grimmond, S.M.; Gut, I.; Hirst, M.; Lopez-Otin, C.; Majumder, P.; Marra, M.; McPherson, J.D.; Ning, Z.; Puente, X.S.; Ruan, Y.; Stunnenberg, H.G.; Swerdlow, H.; Velculescu, V.E.; Wilson, R.K.; Xue, H.H.; Yang, L.; Spellman, P.T.; Bader, G.D.; Boutros, P.C.; Flicek, P.; Getz, G.; Guigo, R.; Guo, G.; Haussler, D.; Heath, S.; Hubbard, T.J.; Jiang, T.; Jones, S.M.; Li, Q.; Lopez-Bigas, N.; Luo, R.; Muthuswamy, L.; Ouellette, B.F.; Pearson, J.V.; Quesada, V.; Raphael, B.J.; Sander, C.; Speed, T.P.; Stein, L.D.; Stuart, J.M.; Teague, J.W.; Totoki, Y.; Tsunoda, T.; Valencia, A.; Wheeler, D.A.; Wu, H.; Zhao, S.; Zhou, G.; Lathrop, M.; Thomas, G.; Yoshida, T.; Axton, M.; Gunter, C.; Miller, L.J.; Zhang, J.; Haider, S.A.; Wang, J.; Yung, C.K.; Cross, A.; Liang, Y.; Gnaneshan, S.; Guberman, J.; Hsu, J.; Chalmers, D.R.; Hasel, K.W.; Kaan, T.S.; Lowrance, W.W.; Masui, T.; Rodriguez, L.L.; Vergely, C.; Bowtell, D.D.; Cloonan, N.; deFazio, A.; Eshleman, J.R.; Etemadmoghadam, D.; Gardiner, B.A.; Kench, J.G.; Sutherland, R.L.; Tempero, M.A.; Waddell, N.J.; Wilson, P.J.; Gallinger, S.; Tsao, M.S.; Shaw, P.A.; Petersen, G.M.; Mukhopadhyay, D.; DePinho, R.A.; Thayer, S.; Shazand, K.; Beck, T.; Sam, M.; Timms, L.; Ballin, V.; Lu, Y.; Ji, J.; Zhang, X.; Chen, F.; Hu, X.; Yang, Q.; Tian, G.; Zhang, L.; Xing, X.; Li, X.; Zhu, Z.; Yu, Y.; Yu, J.; Tost, J.; Brennan, P.; Holcatova, I.; Zaridze, D.; Brazma, A.; Egevard, L.; Prokhortchouk, E.; Banks, R.E.; Uhlen, M.; Viksna, J.; Ponten, F.; Skryabin, K.; Birney, E.; Borg, A.; Borresen-Dale, A.L.; Caldas, C.; Foekens, J.A.; Martin, S.; Reis-Filho, J.S.; Richardson, A.L.; Sotiriou, C.; Thoms, G.; van't Veer, L.; Birnbaum, D.; Blanche, H.; Boucher, P.; Boyault, S.; Masson-Jacquemier, J.D.; Pauporte, I.; Pivot, X.; Vincent-Salomon, A.; Tabone, E.; Theillet, C.; Treilleux, I.; Bioulac-Sage, P.; Decaens, T.; Franco, D.; Gut, M.; Samuel, D.; Zucman-Rossi, J.; Eils, R.; Brors, B.; Korbel, J.O.; Korshunov, A.; Landgraf, P.; Lehrach, H.; Pfister, S.; Radlwimmer, B.; Reifenberger, G.; Taylor, M.D.; von Kalle, C.; Majumder, P.P.; Pederzoli, P.; Lawlor, R.A.; Delledonne, M.; Bardelli, A.; Gress, T.; Klimstra, D.; Zamboni, G.; Nakamura, Y.; Miyano, S.; Fujimoto, A.; Campo, E.; de Sanjose, S.; Montserrat, E.; Gonzalez-Diaz, M.; Jares, P.; Himmelbaue, H.; Bea, S.; Aparicio, S.; Easton, D.F.; Collins, F.S.; Compton, C.C.; Lander, E.S.; Burke, W.; Green, A.R.; Hamilton, S.R.; Kallioniemi, O.P.; Ley, T.J.; Liu, E.T.; Wainwright, B.J. International network of cancer genome projects. Nature. 2010 Apr 15;464(7291):993-998.

Murphy, B.A.; Dietrich, M.S.; Wells, N.; Dwyer, K.; Ridner, S.H.; Silver, H.J.; Gilbert, J.; Chung, C.H.; Cmelak, A.; Burkey, B.; Yarbrough, W.G.; Sinard, R.; Netterville, J. Reliability and validity of the Vanderbilt Head and Neck Symptom Survey: a tool to assess symptom burden in patients treated with chemoradiation. Head Neck. 2010 Jan;32(1):26-37.

Angerer, J., Bird, M. G., Burke, T. A., Doerrer, N. G., Needham, L., Robison, S. H., Sheldon, L. & Zenick, H. (2006). Strategic biomonitoring initiatives: moving the science forward. Toxicol Sci 93, 3-10.

Arredondo, A., Burke, T. A., Carides, G. W., Lemus, E. & Querol, J. (2005). The impact of losartan on the lifetime incidence of ESRD and costs in Mexico. Rev Invest Clin 57, 399-405.

Burke, T. A., Sturkenboom, M. C., Lu, S. E., Wentworth, C. E., Lin, Y. & Rhoads, G. G. (2006). Discontinuation of antihypertensive drugs among newly diagnosed hypertensive patients in UK general practice. J Hypertens 24, 1193-200.

Gallicchio, L., K. Visvanathan, A. Burke, S. C. Hoffman, and K. J. Helzlsouer. 2007. Nonsteroidal anti-inflammatory drugs and the risk of developing breast cancer in a population-based prospective cohort study in Washington County, MD. Int J Cancer 121:211-15.

Gallicchio, L., Kouzis, A., Genkinger, J. M., Burke, A. E., Hoffman, S. C., Diener-West, M., Helzlsouer, K. J., Comstock, G. W. & Alberg, A. J. (2006). Active cigarette smoking, household passive smoke exposure, and the risk of developing pancreatic cancer. Prev Med 42, 200-5.

Herren, T., Burke, T. A., Das, R. & Plow, E. F. (2006). Identification of histone H2B as a regulated plasminogen receptor. Biochemistry 45, 9463-74.

Laheru, D., Lutz, E., Burke, J., Biedrzycki, B., Solt, S., Onners, B., Tartakovsky, I., Nemunaitis, J., Le, D., Sugar, E., Hege, K., and Jaffee, E. (2008). Allogeneic granulocyte macrophage colony-stimulating factor-secreting tumor immunotherapy alone or in sequence with cyclophosphamide for metastatic pancreatic cancer: a pilot study of safety, feasibility, and immune activation. Clin Cancer Res 14, 1455-1463.

Phatak, H., Wentworth, C., and Burke, T.A. (2008). Lipid Testing among Patients Beginning Statin Therapy in General Practice in the United Kingdom. Value Health. 11, 933-938.

Resnick, B., Zablotsky, J., Nachman, K., and Burke, T. (2008). Examining the front lines of local environmental public health practice: a Maryland case study. J Public Health Manag Pract 14, 42-50.

Rohrmann, S., J. M. Genkinger, A. Burke, K. J. Helzlsouer, G. W. Comstock, A. J. Alberg, and E. A. Platz. 2007. Smoking and risk of fatal prostate cancer in a prospective U.S. study. Urology 69:721-5.

Small, E. J., Carducci, M. A., Burke, J. M., Rodriguez, R., Fong, L., van Ummersen, L., Yu, D. C., Aimi, J., Ando, D., Working, P., Kirn, D. & Wilding, G. (2006). A phase I trial of intravenous CG7870, a replication-selective, prostate-specific antigen-targeted oncolytic adenovirus, for the treatment of hormone-refractory, metastatic prostate cancer. Mol Ther 14, 107-17.

Trimble, C. L., Genkinger, J. M., Burke, A. E., Hoffman, S. C., Helzlsouer, K. J., Diener-West, M., Comstock, G. W. & Alberg, A. J. (2005). Active and passive cigarette smoking and the risk of cervical neoplasia. Obstet Gynecol 105, 174-81.

Wenseleers, T., Badcock, N. S., Erven, K., Tofilski, A., Nascimento, F. S., Hart, A. G., Burke, T. A., Archer, M. E. & Ratnieks, F. L. (2005). A test of worker policing theory in an advanced eusocial wasp, Vespula rufa. Evolution Int J Org Evolution 59, 1306-14.