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Research Interests: Obesity and congestive heart failure, Leptin signaling and cardiac hypertrophy, Beta 3 adrenergic signaling and cardiac remodeling, Cardioprotective effect of beta-3 adrenergic receptor signaling
Research Interests: obesity, weight control
Research Interests: Endocrinology, Gonadal dysfunction, hyperlipidemia, diabetes mellitus
Research Interests: Sterol synthesis, Sterol regulatory element binding protein (SREBP), Regulation of sterol homeostasis, Dissolved gases, Insoluble lipids, Cholesterol, Eukaryotic cells, Oxygen sensing, Hypoxia, Homeostasis, Cell function, Mechanisms of molecular sensing
Research Interests: Protein trafficking and localization, Epithelial cell biology, Polycystic kidney disease, Gene therapy, Ion channels, Cystic fibrosis
Research Interests: Dynamic O-GlcNAcylation of nuclear and cytosolic proteins
Research Interests: Diabetes mellitus, Pancreatic beta-cell biology, Pancreatic beta cell regeneration, Pancreatic insulin secretion models
Research Interests: Osteonecrosis, Total Joint Replacement, Bone Graft and Bone Graft Substitutes, Animal models of musculoskeletal disease
Research Interests: Regulation of mammalian development and adult tissue homeostasis by growth and differentiation factors
Research Interests: Neural and Epigenetic Bases of Psychiatric Disorders, Obesity, Brain/Gut Interactions in the Controls of Food Intake
Research Interests: Cell energetics
Research Interests: Physiological functions of DGKs in neurons, Enzyme structure/function studies, Interfacial enzymology of lipid metabolizing signaling enzymes
Research Interests: Signaling Mechanisms, Bioactive Food Components, Novel Therapeutics, Tamoxifen Resistance, Metastasis, Adipocytokines, Obesity-Cancer Connection, Breast Cancer
Research Interests: Metabolic enzymes in neurons, Metabolites, Obesity, Metabolism, Diabetes
Research Interests: Mechanisms of insulin resistance and type 2 diabetes, Function of adipose-and skeletal muscle-derived hormones, Mechanisms governing metabolic homeostasis
Research Interests: Insulin resistance, Hypertension, Novel risk factors for CVD, Genetic epidemiology
Research Interests: Viral oncology, Transcription regulation, Systems biology, Protein chip approach to study proteomics, Host-pathogen interaction, Protein networks, Signal transduction
Department of Psychiatry and Brain Sciences
Dr. Aja studies the role of the protein AMP-activated kinase (AMPK) as an energy gauge in the hypothalamus. AMPK potentially senses and integrates metabolic, neural, and hormonal signals of bodily energy status. Her lab aims to understand the involvement of AMPK in controlling food intake and energy expenditure to regulate adiposity and body weight. AMPK activity might be affected by hypothalamic neuronal fatty acid metabolism. Her team also is interested in understanding how AMPK activity adjusts hypothalamic neuropeptide outputs to control energy balance as well as physiological and behavioral outcomes.
Department of Surgery
Email Dr. Shermak
Michele Shermak, M.D., is the Chief of Plastic Surgery at the Johns Hopkins Bayview Medical Center and also a member of the Center for Bariatric Surgery. Clinically, she specializes in the latest techniques in aesthetic and breast surgery. Her research focuses on the basic science of soft tissue healing, bone healing, and tissue engineering, and she is also interested in the effects of weight loss on adipocyte physiology and metabolism.