Regulation of the gonadotropin-releasing hormone (GnRH) gene by sex steroids, neurotransmitters, and growth factors, Prevention of obesity and diabetes in children, The molecular basis of hypogonadotropic hypogonadism, The developmental biology of hypothalamic and pituitary neuroendocrine cells, The molecular basis of hypopituitarism
Viral oncology, Transcription regulation, Systems biology, Protein chip approach to study proteomics, Host-pathogen interaction, Protein networks, Signal transduction
Susan Aja Department of Psychiatry and Brain Sciences
Dr. Aja studies the role of the protein AMP-activated kinase (AMPK) as an energy gauge in the hypothalamus. AMPK potentially senses and integrates metabolic, neural, and hormonal signals of bodily energy status. Her lab aims to understand the involvement of AMPK in controlling food intake and energy expenditure to regulate adiposity and body weight. AMPK activity might be affected by hypothalamic neuronal fatty acid metabolism. Her team also is interested in understanding how AMPK activity adjusts hypothalamic neuropeptide outputs to control energy balance as well as physiological and behavioral outcomes.
Michele Shermak, M.D., is the Chief of Plastic Surgery at the Johns Hopkins Bayview Medical Center and also a member of the Center for Bariatric Surgery. Clinically, she specializes in the latest techniques in aesthetic and breast surgery. Her research focuses on the basic science of soft tissue healing, bone healing, and tissue engineering, and she is also interested in the effects of weight loss on adipocyte physiology and metabolism.