Cynthia Wolberger, Ph.D.

Additional Information

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Key Publications

Bheda P, Wang JT, Escalante-Semerena JC, Wolberger C. (2010). Structure of Sir2Tm bound to a propionylated peptide. Protein Sci. 20, 131-139. PubMed Link

HOT PAPER!
Samara NL, Datta AB, Berndsen CE, Zhang X, Yao T, Cohen RE, Wolberger C. (2010). Structural insights into the assembly and function of the SAGA deubiquitinating module. Science 328, 1025-1029. PubMed Link

Wang T, Yin L, Cooper EM, Lai MY, Dickey S, Pickart CM, Fushman D, Wilkinson KD, Cohen RE*, Wolberger C.* (2009). Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of Otubain 1. J. Molec. Biol. 386, 1011-1023. *Co-corresponding authors. PubMed Link

Feeser E, Wolberger C. (2008). Structural and functional studies of the Rap1 C-terminus reveal novel separation-of-function mutants. J. Mol. Biol. 380, 520-531. PubMed Link

Hawse WF, Hoff KG, Fatkins D , Daines A, Zubkova OV, Schramm VL , Zheng W, Wolberger C. (2008). Structural Insights Into Intermediate Steps in the Sir2 Deacetylation Reaction. Structure. 16, 1368-1377. PubMed Link

Garrity J, Gardner J, Hawse W, Wolberger C, Escalante-Semerena JC. (2007). N-lysine propionylation, a new posttranslational modification for the control of enzyme function. Journal of Biological Chemistry. 282, 30239-30245. PubMed Link

Sauvé AA, Wolberger C, Schramm VL, Boeke JD. (2006). “The biochemistry of sirtuins,” Annual Reviews of Biochemistry. 75, 435-465. PubMed Link

Cosgrove MS, Bever K, Avalos JL, Muhammad S. Zhang X, Wolberger C. (2006). The structural basis of sirtuin substrate affinity. Biochemistry. 45, 7511-21. PubMed Link

Hoff KG, Avalos JL, Sens K, Wolberger C. (2006). Insights into the sirtuin mechanism from ternary complexes containing NAD+ and acetylated peptide. Structure. 14, 1231-1240. PubMed Link

Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla T, Weindruch R, Alt FW, Guarente L. (2006). SIRT4 Regulates Glutamate Dehydrogenase and Insulin Secretion in Pancreatic Beta Cells. Cell. 126, 941-954. PubMed Link

Avalos JL, Bever KM, Wolberger C. (2005). Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. Molecular Cell. 17, 855-68. PubMed Link