The Van Eyk research lab studies the underlying molecular mechanism of heart disease.
We use a wide variety of proteomic strategies that allow us to screen and characterize protein changes within the large number of subproteomes that comprise the cell. Animal models and human tissue or serum samples from acute and chronic heart disease are analyzed using large number of different protein/peptide separation methods coupled to mass spectrometry.
The goal is to identify the proteins and their isoform or post translational modifications that collectively produce the dysfunction that characterizes the disease phenotype. Coupling the detailed proteomic analysis with bioinformatics, cellular modeling and functional analysis allows us to piece together the complexity and the dynamics of the system. On the practical side, this information can provide leads for the development of therapeutics as well as identify potential biomarkers for the diagnosis, prognosis and risk stratification of heart disease.
|Contact Information:||Dr. Jennifer E. Van Eyk|
410-550-8510 Fax: 410-550-8511
|Laboratory Location:||602 Mason F. Lord Bldg., Center Tower,|
JHU Bayview Campus
Proteomic analysis of heart disease: from molecular mechanism to biomarker development
Major funding sources
Industry Partnerships with
|Active Projects:||1. Biomarker development in the areas of myocardial ischemia, aortic dissection, sudden death and heart failure|
2. Stem cell and cardiac progenitors cells in the areas of cell surface markers and the mechanism underlying control of differentiation.
3. Heart failure in the areas of phosphorylation in mitochondrial and myofilament regulation and membrane protein cell localization.
4. Myocardial ischemia and preconditioning in the areas of phosphorylation in mitochondrial regulation.