1) The Coronary Artery Risk Development in Young Adults (CARDIA) Study
This is a longitudinal study of the antecedents and risk factors for cardiovascular disease in a cohort of 5,115 black and white men and women aged 18-30 years at their initial examination in 1985-1986. In year 25 (2010-2011), these participants will be given an echocardiography examination. Johns Hopkins has been awarded the contract to read these echos.
2) The MESA (Multi-Ethnic Study of Atherosclerosis) Study
This is an important medical research study that involves more than 6,000 men and women from six communities in the United States. Participants in MESA come from diverse racial and ethnic groups, including African Americans, Latinos, Asians, and Caucasians. Participants have gotten a cardiac MRI in previous years and will get a follow-up one in exam 5 (2010 and 2011). Johns Hopkins has been awarded the contract to read these MRIs.
3) The Core 64 Trial:
The Coronary Artery Evaluation using 64-row Multidetector Computed Tomography Angiography (CORE64) study was a prospective, multicenter diagnostic study which utilized centralized blinded analysis to determine the diagnostic accuracy of 64-detector 0.5mm slice thickness MDCT angiography in comparison with conventional coronary angiography (CCA), in patients with suspected CAD. The study was designed to determine whether 64-detector MDCT angiography can reliably define the presence or absence of obstructive disease and also identify those patients who may require coronary revascularization. Nine centers enrolled 291 patients who completed MDCT angiography prior to CCA, and had calcium scores ?600. Diameter stenoses ?50% were considered obstructive. The Core-64 trial showed that 64-detector MDCT angiography has reliable accuracy for the diagnosis of obstructive coronary disease. The area under the receiver operating characteristic curve of 0.93 is consistent with robust diagnostic performance and indicates that 64-detector MDCT angiography has powerful discriminative ability to identify patients with and without coronary obstruction. Additionally, MDCT angiography compared well with CCA in predicting clinically-driven revascularization and severity of obstructive CAD which supports its clinical utility for identifying symptomatic patients who may need coronary interventions.