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Heart & Vascular Institute

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Lima Lab

The Lima lab’s research is concentrated on the development and application of imaging and technology to address scientific and clinical problems involving the heart and vascular system. Our research is focused on deloping MR contrast techniques to investigate microvascular function in patients and experimental animals with myocardial infarction; functional reserve secondary to dobutamine stimulation and myocardial viability assessed by sodium imaging. Cardiac MR and CT program development of techniques to characterize atherosclerosis in humans with cardiovascular or cerebrovascular disease.

Funding

Our current funding is from NIH: NHLBI.

Members

Faculty:

  • Principal Investigator: Joao Lima, MD
  • Co-Principal Investigator: Sam Gidding, MD
  • Co-investigator: David Bluemke, MD, PhD
  • Co-investigator: Chris Sibley, MD

Staff:

  • Erin Ricketts, Study Manager
  • Ellen Stengel, Lead technician
  • Ela Chamera, Sonographer/Analyst
  • Chia-Ying Liu

Fellows:

  • Harjit Chahal
  • Aditya Jain
  • Cuilian Miao
  • Jan Skrok
  • Monda Shehata
  • Evrim Turkbey
  • Andre Almeida
  • Anders Opdahl
  • Eui-Young Choi

Projects

1) The Coronary Artery Risk Development in Young Adults (CARDIA) Study

This is a longitudinal study of the antecedents and risk factors for cardiovascular disease in a cohort of 5,115 black and white men and women aged 18-30 years at their initial examination in 1985-1986. In year 25 (2010-2011), these participants will be given an echocardiography examination. Johns Hopkins has been awarded the contract to read these echos.

2) The MESA (Multi-Ethnic Study of Atherosclerosis) Study

This is an important medical research study that involves more than 6,000 men and women from six communities in the United States. Participants in MESA come from diverse racial and ethnic groups, including African Americans, Latinos, Asians, and Caucasians. Participants have gotten a cardiac MRI in previous years and will get a follow-up one in exam 5 (2010 and 2011). Johns Hopkins has been awarded the contract to read these MRIs.

3) The Core 64 Trial:

The Coronary Artery Evaluation using 64-row Multidetector Computed Tomography Angiography (CORE64) study was a prospective, multicenter diagnostic study which utilized centralized blinded analysis to determine the diagnostic accuracy of 64-detector 0.5mm slice thickness MDCT angiography in comparison with conventional coronary angiography (CCA), in patients with suspected CAD. The study was designed to determine whether 64-detector MDCT angiography can reliably define the presence or absence of obstructive disease and also identify those patients who may require coronary revascularization. Nine centers enrolled 291 patients who completed MDCT angiography prior to CCA, and had calcium scores ?600. Diameter stenoses ?50% were considered obstructive. The Core-64 trial showed that 64-detector MDCT angiography has reliable accuracy for the diagnosis of obstructive coronary disease. The area under the receiver operating characteristic curve of 0.93 is consistent with robust diagnostic performance and indicates that 64-detector MDCT angiography has powerful discriminative ability to identify patients with and without coronary obstruction. Additionally, MDCT angiography compared well with CCA in predicting clinically-driven revascularization and severity of obstructive CAD which supports its clinical utility for identifying symptomatic patients who may need coronary interventions.

Publications

  1. Lima JA, Judd RM, Bazille A, Schulman SP, Atalar E, Zerhouni EA. Regional heterogeneity of perfusion within human myocardial infarcts demonstrated by contrast enhanced ultrafast MRI. Circulation. 1995;92: 1117-1125.
  2. Rochitte CE, Lima JA, Bluemke DA, Reeder SB, McVeigh ER, Furuta T, Becker LC, Melin  JA. The magnitude and time course of microvascular obstruction and tissue injury after acute myocardial infarction. Circulation. 1998;98:1006-1014.
  3. Wu KC, Zerhouni EA, Judd RM, Lugo-Olivieri CH, Barouch LA, Schulman SP, Blumenthal RS, Lima JA. The Prognostic Significance of Microvascular Obstruction by Magnetic Resonance Imaging in Patients with Acute Myocardial Infarction. Circulation. 1998;97:765-772.
  4. Rochitte CE, Kim RJ, Hillenbrand HB, Chen EL, Lima JA.  Microvascular Integrity and the Time Course of Myocardial Sodium Accumulation after Acute Infarction. Circulation Research. 2000;87:648-655.
  5. Lima JA, Desai MY, Steen H, Warren WP, Gautam S, Lai S.  Statin Induced Cholesterol Lowering and Plaque Regression after 6 months of MRI Monitored Therapy. Circulation 2004 Oct;110(16):2336-41.
  6. Rosen BD, Edvardsen T, Lai S, Castillo E, Pan L, Jerosch-Herold M, Sinha S, Kronmal R, Arnett D, Crouse JR 3rd , Heckbert SR, Bluemke DA, Lima JA. Left Ventricular Concentric Remodeling is Associated with Decreased Global and Regional Systolic Function: The Multi-Ethnic Study of Atherosclerosis. Circulation 2005;112-984-991.
  7. Miller JM, Rochitte CE, Dewey M, Arbab-Zadeh A, Niinuma H, Gottlieb I, Paul N, Clouse ME, Shapiro EP, Hoe J, Lardo AC, Bush DE, de Roos A, Cox C, Brinker J, Lima JA. Diagnostic Performance of Coronary Angiography by 64-Row Multidetector Computed Tomography. N Engl J Med 2008; 359:2324-36.
  8. Mewton N, Liu CY, Pierre C, Bluemke D, Lima JA. Assessment of Myocardial Fibrosis with Cardiac Magnetic Resonance. J Am Coll Cardiol 2011 Feb 22;57(8):891-903.
  9. Redheuil A, Yu WC, Wu CO, Mousseaux E, de Cesare A, Yan R, Kachenoura N, Bluemke DA, Lima JA. Reduced ascending aorta strain and distensibility: earliest manifestations of vascular aging in humans. Hypertension 2010 Feb;55(2):319-26.
  10. Yoneyama K, Gjesdal O, Choi EY, Wu CO, Hundley WG, Gomes AS, Liu CY, McClelland RL, Bluemke DA, Lima JA. Age, Sex and Hypertension-related Remodeling Influences Left Ventricular Torsion Assessed by Tagged Cardiac Magnetic Resonance in Asymptomatic Individuals: the Multi-Ethnic Study of Atherosclerosis. Circulation 2012 Nov 20;126(21):2481-90.