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Judge Lab

The overall focus of the Judge lab is on translational cardiovascular genetics.

We are currently investigating genetics and pathophysiology of Arrhythmogenic Right Ventricular Dysplasia (ARVD), genetic mechanisms of mitral valve disease, and the genetics of inherited cardiomyopathies.

Contact Information:

Dr. Daniel P. Judge
(410) 614-3085

Laboratory Location:  

Ross 1049; 720 Rutland Ave
Baltimore, MD 21205
    

Research Focus:  

Dr. Judge's  laboratory is primarily involved with research regarding the genetic basis for inherited forms of cardiovascular disease.  These include familial forms of cardiomyopathy (ARVD, HCM, Dilated, and Restrictive), and genetic aortic diseases (Marfan syndrome, Loeys-Dietz syndrome).      

Funding Support:  

NIH/NHLBI
Donald W. Reynolds Foundation
Foundation Leducq
JHU Ladies In Red
Dana and Albert "Cubby" Broccoli Center for Aortic Diseases
     

Active Projects:

Dr. Judge's laboratory is primarily involved with research regarding the genetic basis for inherited forms of cardiovascular disease.  Research projects include:

  • Genetic investigation of various forms of cardiomyopathy (ARVD, hypertrophic, dilated, and restrictive);
  • Genetic factors contributing to sudden cardiac death;
  • Relationship between inherited forms of cardiomyopathy and related forms of muscular dystrophy; and
  • The causes and best treatments for the cardiovascular manifestations of Marfan syndrome and related vascular diseases.

Laboratory Collaborators:  

Hal Dietz, MD
Eduardo Marbán, MD, PhD
Peter Spooner, PhD    
Hugh Calkins, MD                          
Ronald D. Cohn, MD                   
Kathryn R. Wagner, MD, PhD    
Gordon Tomaselli, MD
Robert A. Levine, MD
Bart Loeys, MD, PhD
Jeffrey Towbin, MD, PhD
Nazareno Paolocci, PhD
Suneel S. Apte, M.B.B.S., D.Phil
Carolyn Y. Ho, MD
(and others)
    
     

Selected Bibliography:

Judge DP, Biery NJ, Keene DR, et al. “Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome.” Journal of Clinical Investigation 2004, 114:172-81.

Loeys BL, Chen J, Neptune ER, Judge DP, et al, “A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2.” Nature Genetics 2005; 37:275-81.

Dalal D, ... Calkins H, Judge, DP. “Clinical features of Arrhythmogenic Right Ventricular Cardiomyopathy due to mutations in plakophilin-2.” Circulation 2006; 113:1641-9.

Habashi JP*, Judge DP*(co-first author),... and Dietz HC. “Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome.”  Science 2006; 312:117-21.                    

Awad MM, Dalal D, ..., Judge DP. “DSG2 mutations contribute to arrhythmogenic right ventricular dysplasia/cardiomyopathy.” American Journal of Human Genetics, 2006; 79:136-42.    

Cohn RD, van Erp C, Habashi JP, ..., Judge DP, Ward CW, Dietz HC.  “Angiotensin II Type 1 Receptor Blockade Attenuates TGF?-induced Failure of Muscle Regeneration in Multiple Myopathic States.”  Nature Medicine, 2007; 13:204-210.

 

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