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George Lab Projects

Current Projects:

CORE 320 – Coronary Evaluation using 320 Detector CT

CORE 320 is a multi-center international clinical trial aimed at validating CT angiography and CT perfusion imaging compared with the combination of invasive angiography and single photon emission computed tomography. The trial includes 16 sites from North America, South America, Europe, and Asia. Dr. George is the principle investigator for the CT perfusion core lab at Johns Hopkins University.

The long-term goal of this study is to improve the non-invasive diagnosis of coronary artery disease.

Combined CT angiography and CT Perfusion Imaging using 320, 256, and 64 Detector Computed Tomography

Based on preclinical studies of CT perfusion imaging, there are several ongoing and completed single center clinical trials of CT perfusion imaging using CT scanning systems with 64, 256, and 320 detector arrays. The overall aim of the projects is to demonstrate that cardiac CT can accurately acquire CT angiography and perfusion imaging data in a single 20 minute CT examination. The goal is to simultaneously detect coronary atherosclerosis and its physiologic significance. The development of effective imaging protocols, reconstruction algorithms, and myocardial perfusion analysis software have been key to the clinical implementation of these protocols.

CT Angiography Perfusion, Viability, and Functional Imaging for Phenotyping Patients at Risk for Sudden Cardiac Death

This study is a sub-project within the Donald W. Reynolds Cardiovascular Clinical Research Center at Johns Hopkins University. The goal of the study is to implement high-resolution CT imaging in patients at risk for sudden cardiac death. The study aims to use CT angiographic, functional, perfusion, and scar imaging to better characterize arrhythmogenic substrate for sudden cardiac death.

Preclinical Validation of CT Perfusion and PET Perfusion Imaging

Several large animal studies have been completed or are in progress validating CT perfusion, CT viability, and quantitative PET imaging in animal models of myocardial ischemia and acute and chronic myocardial infarction.

Preclinical Validation of Perfusion Imaging using Fluoroscopy

Invasive angiography is the current gold standard for defining coronary anatomy and defining percent diameter stenosis in the setting of coronary artery disease. However, invasive angiography is only a moderate predictor of the physiologic significance of coronary stenoses. The primary aim of this study is to validate a novel perfusion imaging method that uses contrast enhanced fluoroscopy imaging during invasive angiography. The long-term goal will be to provide both coronary anatomical and physiological information from a coronary angiogram.