Current Funding Sources:
PO1 HL065608 (L Becker) 9/15/2000-3/31/2011 3.6 calendar
Inflammation and Repair in Cardiac Ischemia-Reperfusion
Goal: This Program Project application is a multidisciplinary laboratory and clinical research program focused on the cellular mechanisms underlying post-ischemic myocardial inflammation, emphasizing the role of redox-sensitive events in vascular endothelial cells and myocytes which mediate gene transcription and neutrophil (PMN accumulation).To define the mechanisms of inflammation and repair in the heart after ischemia and reperfusion.
R21HL088071-01A2S1 (Z Cai) 7/07/2009-6/30/2111 6.0 calendar months
Role of Phosphatase PTEN in Ischemic Preconditioning (miR21-Mediated PTEN Downregulation in Late IPC)
Goal: The study is designed to determine the interaction between miR21 and PTEN protein expression in late ischemic preconditioning and provide additional evidence that PTEN plays an important role in ischemic preconditioning.