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Loeys-Dietz syndrome is a genetic disorder of the connective tissue — cells that support or connect different structures in the body. Loeys-Dietz syndrome affects bones, blood vessels, skin, heart and other organs. Common signs include wide-set eyes, aortic or arterial aneurysm or dissection and a variety of skeletal, skin and digestive features.
Although Loeys-Dietz syndrome shares features with other connective-tissue disorders such as Marfan, Shprintzen-Goldberg and Ehlers-Danlos syndromes, it stems from different genetic mutations. The conditions are also managed differently.
Meet Dr. Harry (Hal) Dietz, whose discovery of genes for Loeys-Dietz and Marfan syndromes is contributing to treatments for these and other conditions..
Our physicians are world experts in the diagnosis and treatment of Loeys-Dietz syndrome.
For Cardiovascular Complications
For Orthopaedic Complications
For Digestive Complications
The Johns Hopkins Center for Inherited Diseases counsels and screens patients and their families with Loeys-Dietz syndrome. Dr. Harry Dietz of the Center for Inherited Diseases was involved in identifying this condition.
Johns Hopkins researchers found that people with Loeys-Dietz syndrome are prone to low bone density. This finding helps patients better protect themselves and provides researchers with avenues for new therapies.