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Chronic Kidney Disease Research

Chronic kidney disease is a worldwide public health problem. In the United States, there is a rising incidence and prevalence of kidney failure, with poor outcomes and high cost. There is an even higher prevalence of earlier stages of chronic kidney disease. Increasing evidence, accrued in the past decades, indicates that the adverse outcomes of chronic kidney disease, such as kidney failure, cardiovascular disease, and premature death, can be prevented or delayed. Earlier stages of chronic kidney disease can be detected through laboratory testing. Treatment of earlier stages of chronic kidney disease is effective in slowing the progression toward kidney failure. Initiation of treatment for cardiovascular risk factors at earlier stages of chronic kidney disease should be effective in reducing cardiovascular disease events both before and after the onset of kidney failure.

At Hopkins GIM, our faculty are investigating several different aspects of the CKD epidemic, including: (1) genetics of CKD; (2) natural history of CKD and transition to renal failure; (3) screening for CKD in the general population; (4) optimal treatment to prevent progression; (5) optimal regime once renal replacement therapy is required; and (6) epidemiology and prevention of vascular complications in end-stage renal disease.

Information about the faculty working in this research area and their projects is provided below.

Lawrence Appel, MD, MPH

Professor of Medicine, Epidemiology, and International Health
Director, Welch Center for Prevention, Epidemiology, and Clinical Research

Research Interests: Prevention of blood pressure-related cardiovascular and kidney diseases through pharmacologic and non-pharmacologic approaches, often nutrition-based.

To see publication abstracts: PUBMED

Josef Coresh, MD, PhD

Professor of Epidemiology and Medicine
Core Faculty, Welch Center for Prevention, Epidemiology, and Clinical Research
Director, George W. Comstock Center for Public Health Research and Prevention (GWCC)

Research Interests: Epidemiology and prevention of CKD, cardiovascular disease in CKD and ESRD, biomarkers in CKD

To see publication abstracts: PUBMED

Raquel Charles Greer, MD, MHS

Assistant Professor of Medicine

Research Interests: Quality of primary care for patients with CKD, patient education interventions to improve clinical outcomes and address race disparities in CKD care

To see publications abstracts: PUBMED

Michael Klag, MD, MPH

Professor of Epidemiology
Health Policy and Management, and Medicine
Dean, Johns Hopkins Bloomburg School of Public Health

Core Faculty, Welch Center for Prevention, Epidemiology and Clinical Research

Research Interests: Genetic epidemiology of diabetic nephropathy; hypertension and CKD

To see publication abstracts:PUBMED

Elizabeth Selvin, PhD, MPH

Associate Professor of Epidemiologyand Medicine

Core Faculty, Welch Center for Prevention, Epidemiology and Clinical Research

Research Interests: Diabetic nephropathy, screening for CKD

To see publication abstracts: PUBMED

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