Studies within this group range from molecular and cellular to genetic and laboratory animal-based approaches targeted to understanding the mechanisms, risk factors, and pathophysiology of aging-related changes in health, function, and quality of life.
In addition, this group has considerable expertise in the development of clinical translational studies in human populations, epidemiological studies in populations of older adults, and in clinical intervention trials.
The major aims of this group are to:
- Determine genetic influences on age-related decline in strength
- Investigate etiologies for age-related activation in inflammatory pathways and its consequences on the development of anemia, sarcopenia, cognitive decline, osteopenia, and other chronic diseases of older adults
- Develop treatments that focus on inflammation and its consequences
- Investigate the causes and treatments for immunosenescence in older adults
- Explore the consequences of aging-related changes in mitochondria on health and well being
- Develop and validate physiotypes of frailty and robust health in older adults by integrating genetic, cellular, and clinical level phenomena into integrative biological models
- Translate biological findings into results that optimize quality of life and healthy aging
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