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Genetic Determinants of Aging Phenotypes

Human Genetics

 Human genetic studies have greatly accelerated the discovery of relevant biological pathways that influence chronic disease and aging phenotypes. 

Research focus

Through participation in consortiums of investigators working in the Cardiovascular Health Study and the Health ABC Study, investigators within the Biology of Healthy Aging Research Program have ongoing funded studies that are exploring genetic influences for muscle strength decline, inflammatory pathway activation, and the phenotype of frailty.

This work is taking place in collaboration with investigators in the Johns Hopkins Claude D. Pepper Older Americans Independence Center.

Researchers continue to evaluate genome-wide associations with inflammation, grip strength, and frailty.

Current research studies

  • Genome-wide association studies of muscle strength decline, anemia of inflammation, chronic inflammation, frailty


Dan Arking, PhD
Karen Bandeen-Roche, PhD, MS
Brock Beamer, MD
Aravinda Chakravarti, PhD
Margaret Daniele Fallin, PhD
Alexander P. Reiner, MD, MSc
Qian-li Xue, PhD

Faculty investigators

Jeremy Walston, MD
Amy Matteini, PhD