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Yaohui Zhu

Research Associate

yaho hui zhu

Phone number: 410-955-8607

Research interest: Neurogastromotility 
Clinical interests: Motility disorder and visceral pain in translational research

Schools\degrees: M.D., Wuhan University
Training: Research fellow, McMaster University

Research summary

Dr. Zhu’s research focuses on visceral nociception and gut neuromotility, in which the ion channels are evaluated and characterized.

Journal citations

  1. Cuiping Li, Yaohui Zhu, Mohan Shenoy, Reetesh Pai, Liansheng Liu and Pankaj Jay Pasricha “Anatomical and functional characterization of a duodeno-pancreatic neural reflex that can induce acute pancreatitis” Am J Physiol Gastrointest Liver Physiol, 2013 Jan PMID: 23306082
  2. Yaohui Zhu, Tugba Colak, Mohan Shenoy, Liansheng Liu, Kshama Mehta, Reetesh Pai, Bende Zou, Xinmin Xie, Pankaj J. Pasricha “Transforming growth factor beta induces sensory neuronal hyperexcitability, pancreatic pain and hyperalgesia in rats with chronic pancreatitis” Molecular Pain,  2012 Sep 11;8(1):65 PMID: 22963239
  3. Yaohui Zhu, Kshama Mehta, Cuiping Li, Guang-Yin Xu, Liansheng Liu, Tugba Colak, Mohan Shenoy, Pankaj Jay Pasricha “Systemic administration of anti-NGF decreases pancreatic nociceptor excitability and A-type potassium currents in a rat model of chronic pancreatitis” Am J Physiol Gastrointest Liver Physiol, 2012 Jan; 302(1): G176-81 PMID:22038828
  4. Yaohui Zhu, Tugba Colak, Mohan Shenoy, Liansheng Liu, Reetesh Pai, Cuiping Li, Kshama Mehta, Pankaj Jay Pasricha  ”Nerve Growth Factor Modulates TRPV1 Expression and Function and Mediates Pain in Chronic Pancreatitis” Gastroenterology, 2011 (141), 370-77PMID: 21473865
  5. JD Huizinga, WJ Lammers, HB Mikkelsen, Y Zhu, XY Wang “Toward a concept of stretch coupling in smooth muscle: a thesis by Lars Thuneberg on contractile activity in neonatal interstitial cells of Cajal” Anat Rec (Hoboken). (2010) 293(9): 1543-52. PMID: 20687173
  6. Yaohui Zhu, Sean P. Parsons & Jan D. Huizinga  “Measurement of intracellular chloride ion concentration in ICC in situ and in explant culture” Neurogastroenterology and Motility, Neurogastroenterol Motil, (2010) (22), 704–709PMID: 20403100
  7. Yaohui Zhu and Huizinga “Nitric oxide decreases the excitability of interstitial cells of Cajal through activation of the BK channel” J Cell Mol Med. (2008) (12-5A): 1718-27 PMID: 18194464.
  8. Wang B, Kunze WA, Zhu Y, Huizinga JD. “In situ recording from gut pacemaker cells” Pflugers Arch. (2008) (457-1): 243-51. PMID: 18458942 [
  9. Yaohui Zhu, Jing Ye and Huizinga “Clotrimazole-sensitive K+ currents regulate pacemaker activity in interstitial cells of Cajal” Am J Physiol Gastrointest Liver Physiol. (2007) (292-6): G1715-25. PMID: 17347448
  10. J Ye, Y Zhu, WI Khan, J Van Snick and JD Huizinga "IL-9 enhances growth of ICC, maintains network structure and strengthens rhythmicity of contraction in culture" J Cell Mol Med. (2006) 10 (3): 687-94 16989728 PMID: 16989728
  11. Sung Jin Park, Catherine M. Golden, Yaohui Zhu and Jan D. Huizinga "Volume-activated chloride currents in interstitial cells of Cajal" Am J Physiol Gastrointest Liver Physiol. (2005) 289(5): G791-7. PMID: 15528256
  12. Yaohui Zhu, Andrea Mucci and Jan D. Huizinga "Inward rectifying chloride channel in pacemaker cells of intestine " Am J Physiol Gastrointest Liver Physiol. Am J Physiol Gastrointest Liver Physiol, (2005) (288; 4): G809-21 PMID: 15528256
  13. L Xu, J Chen, B Yu, W Dong, K Chen, H Luo, Y Zhu. “Effect of progesterone on calcium activated potassium currents and intracellular calcium in guinea pig colon myocytes” Methods Find Exp Clin Pharmacol. (2005) 27(7): 475-82. PMID: 16258592
  14. Jan D. Huizinga, Catherine M. Golden, Yaohui Zhu and Elizabeth J. White "Ion channels in ICC as targets for neurotransmitter action" Neurogastroenterology and Motility; (2004) 15(5) 531-43 PMID: 15066014
  15. Yaohui Zhu, Catherine M.Golden, Jing Ye, Xuan-Yu Wang, Hamid I. Akbarali, and Jan D. Huizinga  "ERG K+ currents regulate pacemaker activity in ICC" Am J Physiol Gastrointest Liver Physiol. (2003) 285(6): G1249-58 PMID: 12958021
  16. JD Huizinga, Y Zhu, J Ye A, Molleman  “High Conductance Chloride Channels Generate Pacemaker Currents in Interstitial Cells of Cajal" Gastroenterology, (2002) Vol123 N. 4 PMID: 12404237
  17. C Barajas-Lopez, R Espinosa-Luna & Yaohui Zhu “Functional interactions between nicotinic and P2X channels in short-term cultures of guinea-pig submucosal neurons” J. of Physiology (London), (1998) 513(3): 671-683 PMID: 9824709
  18. J Li, Y Zhu, DP Singal "HFE gene mutations in patients with rheumatoid arthritis" J Theumatol (2000) 27(9): 2074-7 PMID: 10990216
  19. DP Singal, J Li, Y Zhu "HLA class III region and susceptibility to rheumatoid arthritis" Clin Exp Rheumatol (2000) 18(4): 485-91 PMID: 10949724
  20. DP Singal, J Li, Y Zhu, Zhang G "NRAMP1 gene polymorphisms in patients with rheumatoid arthritis" Tissue Antigens, (2000) 55(1): 44-7 PMID: 10703607
  21. DP Singal, J Li, Y Zhu "Genetic basis for rheumatoid arthritis " Arch Immunol Ther Exp (Warsz); (1999) 47(5): 307-11 PMID: 10604236

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