Samuel Yang, M.D.

•          Associate Professor, 
        Department of Emergency Medicine
•      
        Joint Appointment:
        Institute of NanoBioTechnology,
       Johns Hopkins University
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Education
Massachusetts Institute of Technology (B.S. 1994)
UCLA School of Medicine (M.D., 1999)

Residency
Johns Hopkins School of Medicine, EM (2002)
Research Fellowship: Johns Hopkins School of Medicine (2004)

Background
Dr. Yang is an Associate Professor in the Department of Emergency and holds a joint appointment in the Institute of NanoBioTechnology. Upon completing both his residency and research fellowship in Emergency Medicine at Johns Hopkins. Dr. Yang joined the faculty in 2005.  As a front-line emergency medicine physician with background in molecular & cell biology and clinical investigation, Dr. Yang's research interests have focused on the development and validation of molecular-based point-of-care diagnostics for broad-scale pathogen detection.  Specific clinical applications include sepsis, meningitis, septic arthritis, sexually transmitted diseases, HIV, influenza, and bioterrorism. Dr. Yang also collaborates with JHU Whiting School of Engineering to advance microfluidic technologies into practical diagnostic platforms with enhanced performance and capabilities for use in resource-limited settings. Dr. Yang holds several patents and awards for his ongoing research endeavors supported by NIH, NSF, DHS, and other private funding agencies.

Research Interests

1. Point-of-care device engineering
2. Molecular assay development for infectious diseases
3. Clinical utility of molecular diagnostics

Recent publications

1.  Lin S, Yang S. Molecular methods for pathogen detection in blood. Lancet 2010; 375:178-9.
2.  Won H, Rothman R, Ramachandran P, Hsieh YH, Kecojevic A, Carroll KC, Aird D, Gaydos C, Yang S. Rapid identification of bacterial pathogens in positive blood culture bottles using a broad based PCR assay coupled with High-Resolution Melt Analysis. J Clin Microbiol 2010 Sep;48(9):3410-3.
3. Park S, Zhang Y, Wang TH, Yang S. Continuous dielectrophoretic bacterial  separation and concentration from physiological media of high conductivity. Lab on a Chip 2011 Sep 7;11(17):2893-900.
4. Park S, Zhang Y, Lin S, Wang TH, Yang S. Advances in microfluidic PCR for point-of-care infectious disease diagnostics. Biotechnology Advances 2011 Nov;29(6):830-9.
5. Hardick J, Won H, Jeng K, Hsieh YH, Gaydos CA, Rothman RE, Yang S. Identification of Bacterial Pathogens in Ascitic Fluids from Patients with Suspected Spontaneous Bacterial Peritonitis by Use of Broad-Based PCR (16S PCR) Coupled with High-Resolution Melt Analysis (HRMA). J Clin Microbiol. 2012 May 9 (epub).

See Research Publications

Recent Grants

1. Principal Investigator: "Toward Molecular Point of Care Diagnosis of Early Onset Neonatal Sepsis using Umbilical Cord Blood". The Gerber Foundation.
2. Principal Investigator:"Developing a Point-of-Care Diagnostics for Acute Bacterial Meningitis in Infants and Children". E.W. Al Thrasher Award
3. Co-Principal Investigator: "Microfluidic Single-Cell Melting Curve Analysis for Broad-Scale Detection of Microbial Organisms". National Science Foundation
4. Co-Principal Investigator: "Integrated Single Molecule Color Coding System for Multiplexed Detection of Pathogens". National Science Foundation
5. Principal Investigator: "Development of Electrokinetic based Lab Chip for Rapid Diagnosis of Pediatric Sepsis". The Hartwell Foundation Individual Biomedical Research Award