Center for Advanced Modeling,
Department of Emergency Medicine
Princeton University (Ph.D.)
Dr. Klein is an assistant professor in the Center for Advanced Modeling in the Social, Behavioral and Health Sciences (CAM) in the Department of Emergency Medicine. He is also a fellow at the Center for Disease Dynamics, Economics and Policy, in Washington, D.C.Upon finishing his PhD in ecology and evolutionary biology from Princeton University, Dr. Klein joined the Hopkins faculty in 2012.
Dr. Klein’s research focuses on the role of individuals in the spread of infectious diseases. This area of research sits at the nexus of economics and epidemiology, and is premised on the idea of incorporating incentives for healthy behavior and their attendant behavioral responses into an epidemiological context to better understand how diseases are transmitted. This nascent field of economic epidemiology is based on the idea of improving policy responses to epidemic diseases by giving policymakers and health-care providers clear tools for thinking about how certain actions can influence the spread of disease transmission.
Dr. Klein has authored numerous publications on the evolution and spread of antimicrobial drug-resistance, with particular reference to the emergence of antibiotic and antimalarial drug resistance. Dr. Klein is actively involved in research efforts for Extending the Cure and the Robert Wood Johnson Foundation on understanding the emergence, spread, and economic impact of methicillin-resistant Staphylococcus aureus in the United States, as well as the impact of seasonal changes in antibiotic prescriptions on changes in resistance levels, and how the interaction between the hospital and the community influences different strains of resistance. Dr. Klein is also actively involved in work for the Global Fund and the Bill and Melinda Gates Foundation to support the Affordable Medicines Facility – malaria, a global subsidy intended to increase the availability and lower the cost of the newest and most effective antimalarial drugs, and at the same time decrease the rate at which resistance emerges and spreads.
1. Pathogen competition across space and scale
2. Impact of antimicrobial drug resistance on ecology and epidemiology of disease
3. Economic epidemiology
4. Mathematical and theoretical ecology
5. Evolution of pathogen-host interactions.
1. Klein, Eili, Baykov, Nikolay, Eber, Michael, Morgan, Daniel, Laxminarayan, Ramanan "Trends in Resistance to Carbapenems and Third-Generation Cephalosporins in Clinical Isolates of Klebsiella Pneumoniae in the United States, 1999-2010" Infection Control and Hospital Epidemeology (2013) 34
2. Klein, Eili, Lova Sun, David L. Smith, Ramanan Laxminarayan “The changing epidemiology of methicillin-resistant Staphylococcus aureus in the United States: A national observational study” American Journal of Epidemiology (in press).
3. Sun, Lova, Eili Klein, Ramanan Laxminarayan “Seasonality and Temporal Correlation between Community Antibiotic Use and Resistance in the United States” Clinical Infectious Diseases (2012). doi: 10.1093/cid/cis509
4. Klein, Eili Y., David L. Smith, Ramanan Laxminarayan, and Simon Levin (2012) “Superinfection and the evolution of resistance to antimalarial drugs" Proceedings of the Royal Society, Series B: Biological Sciences. doi: 10.1098/rspb.2012.1064
5. Klein, Eili, David L. Smith and Ramanan Laxminarayan “Community-associated Methicillin-Resistant Staphylococcus aureus in Outpatients, United States, 1999-2006” Emerging Infectious Diseases (2009) 15 (12): 1925-1930.