Charles W. Hogue, Jr., MD

Professor of Anesthesiology & Critical Care Medicine
Chief, Division of Adult Anesthesia
Department of Anesthesiology/Critical Care Medicine
The Johns Hopkins University School of Medicine
The Johns Hopkins Hospital
Sheikh Zayed Tower 6208
1800 Orleans Street
Baltimore, MD 21287
Phone: 410-614-1516
Fax: 410-955-0994
E-mail: chogue2@jhmi.edu
Download CV
www.meddium.com/charleshogue

The primary focus of Dr. Hogue’s research is the study of neurologic outcomes after heart surgery, with particular focus on postmenopausal women. He and his colleagues have just completed an investigation of the role of estrogen replacement and brain injury (Hogue CW Jr, et al. Neurocognitive outcomes are not improved by 17beta-estradiol in postmenopausal women undergoing cardiac surgery. Stroke 38:2048–54, 2007). The group was surprised to find that despite a strong experimental rationale (multiple experimental models—in vitro and in vivo), 17beta-estradiol had no effect on neurologic outcomes after heart surgery in postmenopausal women, that is 17beta-estradiol provided no protection. They found no significant difference between women who received treatment and those who received placebo.

Women are at higher risk for brain injury from heart surgery than are men, and Dr. Hogue’s group is now exploring whether this female susceptibility might be attributable to a vascular etiology. They are specifically attempting to determine whether certain aspects of management during heart surgery can be individualized. If they determine that this is not possible, they will then look toward developing at least gender-specific management strategies during surgery to reduce neurologic complications.

Professional Activities

Alpha Omega Alpha
American Medical Association
American Society of Anesthesiologists
Association of University Anesthesiologists
International Anesthesia Research Society
Maryland Society of Anesthesiologists
Society of Cardiovascular Anesthesiologists

Selected Publications

1. Hogue CW Jr, Freedland K, Hershey T, Fucetola R, Nassief A, Barzilai B, Thomas B, Birge S, Dixon D, Schechtman KB, Dávila-Román VG. Neurocognitive outcomes are not improved by 17beta-estradiol in postmenopausal women undergoing cardiac surgery. Stroke 38:2048–54, 2007.
2. Benjo A, Thompson RE, Fine D, Hogue CW, Alejo D, Kaw A, Gerstenblith G, Shah A, Berkowitz DE, Nyhan D. Pulse pressure is an age-independent predictor of stroke development following cardiac surgery. J Hyperten 2007;50:630–35.
3. Hogue CW, Gottesman R, Stearns J. Mechanisms of cerebral injury from cardiac surgery. Crit Care Clin 24(1):83–98, 2008.
4. Gottesman R, Hogue CW. Incidence, topography, predictors and long term survival following stroke in patients undergoing CABG surgery. (Invited Commentary) Ann Thorac Surg 85(3):870–1, 2008.
5. Hogue CW Jr, Hershey T, Dixon D, Fucetola R, Nassief A, Freedland KE, Thomas B, Schechtman KB, Freedland K. The impact of neurocognitive dysfunction on quality of life after cardiac surgery for postmenopausal women. Anesth Analg (in press)

Laboratory Members/Key Associates

Collaborators
William Baumgartner, MD
Ken Brady, MD
Rebecca Gottesman, MD, PhD
Guy McKahnn, MD
Ola Selns, PhD
Josh Stearns, MD