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Natalia A. Trayanova, M.S., Ph.D.

Photo of Dr. Natalia A. Trayanova, M.S., Ph.D.

Murray B. Sachs Professor of Biomedical Engineering and Medicine

Joint Appointment in Medicine

Expertise: Cardiac Electrophysiology

Research Interests: Cardiac electrophysiology; Ventricular arrhythmias; Atrial arrhythmias; Cardiac mechanics; Defibrillation; Cardiac optogenetics

Background

Dr. Natalia Trayanova is a professor in the Department of Biomedical Engineering and the Institute for Computational Medicine, and directs the Computational Cardiology Laboratory at Johns Hopkins University. Dr. Trayanova is the inaugural Murray B. Sachs Endowed Chair in Biomedical Engineering. In 2013, she received the NIH Director’s Pioneer Award for her project “Virtual Electrophysiology Laboratory”. Dr. Trayanova was also the inaugural William R. Brody Faculty Scholar at Johns Hopkins University. She is a Fellow of the Heart Rhythm Society, American Heart Association, Biomedical Engineering Society, and the American Institute for Medical and Biological Engineering. The translational research in Dr. Trayanova’s Computational Cardiology Laboratory centers around improvement of the clinical therapies of defibrillation and atrial and ventricular ablation, and the risk stratification for arrhythmias using a personalized MRI-based simulation approach. The basic science research in Dr. Trayanova lab focuses on understanding the pathological electrophysiological and electromechanical behavior of the heart, with emphasis on the mechanisms for cardiac arrhythmogenesis and pump dysfunction. Research in Dr. Trayanova’s laboratory is supported by grants from NIH, NSF, and the American Heart Association. Dr. Trayanova has published extensively: she is the author of over 250 peer-reviewed journal publications in prestigious journals (Science Translational Medicine, PNAS, Journal of Clinical Investigations, Nature Communications, Journal of American College of Cardiology, Circulation, Circulation Research, and others). She is the Editor of the book "Cardiac Defibrillation - Mechanisms, Challenges and Implications", InTech Publishing, 2011. Dr. Trayanova has presented at a large number of international meetings and has given numerous keynote and plenary lectures. She and the members of her laboratory are the recipients of a large number of research awards, among which the Excellence in Research and Scholarship Award and Outstanding Researcher Award, and the Fulbright Distinguished Research Award, to name a few. She has also received awards for excellence in teaching. Among her other professional activities, Dr. Trayanova is Associate Editor of the journals Heart Rhythm and Frontiers in Computational Physiology and Medicine; served as an Associate Editor of IEEE Transactions of Biomedical Engineering; is on the Editorial Board of a number of journals. Dr. Trayanova has served as a member of the NIH ESTA and MABS as well as other study sections. Dr. Trayanova was the Vice-Chair in 2007 and the Chair in 2009 of the Gordon Research Conference on Cardiac Arrhythmia Mechanisms, and has served as a member of the program committee of a large number of international meetings. She currently serves on the FDA CIPA Steering Committee and the American Heart Association Research Funding Subcommittee. 

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Titles

  • Murray B. Sachs Professor of Biomedical Engineering and Medicine
  • Joint Appointment in Medicine

Departments / Divisions

Education

Degrees

  • M.S., Sofia University (Bulgaria) (1982)
  • Ph.D., Bulgarian Academy of Sciences - Sofia (Bulgaria) (1986)

Research & Publications

Research Summary

Dr. Trayanova’s Computational Cardiology Lab  conducts both basic science and translational studies of heart dysfunction and therapies for heart disease. Currently, the translational research centers on advancements in the clinical therapies of atrial and ventricular ablation, defibrillation, and the risk stratification for arrhythmias using a personalized imaging-based “virtual-heart” simulation approach. The basic science research focuses on understanding the pathological electrophysiological and electromechanical behavior of the heart, with emphasis on the mechanisms for cardiac arrhythmogenesis and pump dysfunction. Research in Dr. Trayanova’s laboratory is supported by grants from NIH, NSF, and the American Heart Association. Visit the lab website

Lab

Selected Publications

View all on Pubmed

Vadakkumpadan F, Trayanova N, Wu KC. Image-based left ventricular shape analysis for sudden cardiac death risk stratification. Heart Rhythm. 2014 May 20. pii: S1547-5271(14)00549-9. doi: 10.1016/j.hrthm.2014.05.018. [Epub ahead of print] PMID: 24854217

Trayanova NA, Rantner LJ. New insights into defibrillation of the heart from realistic simulation studies. Europace. 2014 May;16(5):705-13. doi: 10.1093/europace/eut330. PMID: 24798960 [PubMed - in process]

Trayanova NA. Mathematical approaches to understanding and imaging atrial fibrillation: significance for mechanisms and management. Circ Res. 2014 Apr 25;114(9):1516-31. doi: 10.1161/CIRCRESAHA.114.302240. Review. PMID: 24763468

Hu Y, Gurev V, Constantino J, Trayanova N. Optimizing cardiac resynchronization therapy to minimize ATP consumption heterogeneity throughout the left ventricle: a simulation analysis using a canine heart failure model. Heart Rhythm. 2014 Jun;11(6):1063-9. doi: 10.1016/j.hrthm.2014.03.021. Epub 2014 Mar 18. PMID: 24657430 [PubMed - in process]

Boyle PM, Park CJ, Arevalo HJ, Vigmond EJ, Trayanova NA. Sodium current reduction unmasks a structure-dependent substrate for arrhythmogenesis in the normal ventricles. PLoS One. 2014 Jan 28;9(1):e86947. doi: 10.1371/journal.pone.0086947. eCollection 2014. PMID: 24489810

Contact for Research Inquiries

3400 N. Charles St.
Hackerman Hall Room 216
Baltimore, MD 21218 map
Phone: 410-516-4375

Academic Affiliations & Courses

Courses and Syllabi

  • Systems Bioengineering I: Cellular and Cardiovascular Engineering. Core undergraduate course in Biomedical Engineering (BME 580.421)

    Activities & Honors

    Honors

    • Discovery Innovation Award, Johns Hopkins School of Medicine, 2015 - 2016
    • NIH Director’s Pioneer Award, NIH, 2013
    • Murray B Sachs Endowed Chair, Johns Hopkins University, 2012
    • Fellow of the Biomedical Engineering Society, 2010
    • Fellow of the American Heart Association, American Heart Association, 2010

    Memberships

    • American Heart Association
    • Heart Rhythm Society
    • American Institute for Medical and Biological Engineering
    • Biomedical Engineering Society IEEE Engineering in Biology and Medicine Society
    • International Society for Heart Research
    • International Society for Computerized Electrocardiology
    • Society for Industrial and Applied Mathematics
    • American Association for Advancement of Science Cardiac Muscle Society
    • Cardiac Electrophysiology Society
    • Biophysical Society
    • New York Academy of Sciences
    • American Society for Engineering Education

    Professional Activities

    • Session Chair, Japanese Heart Rhythm Society, Sapporo, Japan, 2016
    • Session Chair, ISC2016, Tokyo, Japan, 2016
    • Session Chair, Cardiostim Meeting, Nice, France, 2016
    • Session Chair, Western Atrial Fibrillation Symposium, Park City, Utah, 2016
    • Session Chair, TRM Forum, Lugano, Switzerland, 2015

    Videos & Media

    Computer Modeling for Personalized Cardiology

    Natalia Trayanova, Ph.D., on Modeling Cardiac Function and Dysfunction

    Natalia Trayanova - Computational Simulations of the Heart

    Modeling Cardiac Function and Dysfunction

    Natalia Trayanova: Modelling Cardiac Function and Dysfunction

    Lectures and Presentations

    • Cardiac Mechanoelectric Coupling and Arrhythmias
      Keynote lecture, Freiburg, Germany (09/01/2016)
    • Gordon Research Conference on Healthcare Informatics
      Lecture, Hong Kong (07/01/2016)
    • Japanese Heart Rhythm Society
      Lecture, Sapporo, Japan (07/01/2016)
    • ISC2016
      Keynote, Tokyo, Japan (07/01/2016)
    • Cardiostim Meeting
      Lecture, Nice, France (06/01/2016)

    Recent News Articles and Media Coverage

     

    Researchers Looking to Help Those with Heart Arrhythmia

    Virtual hearts help doctors spot patients most at riskfrom fatal arrhythmias

    Natalia Trayanova on Developing Computer Simulations of Hearts

    Trayanova's Lab Looks At Gentle Beams Of Light

    This Engineer Can Design Your Virtual Heart

    Opinion: Model Organ

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