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Shaoyong Yu, M.D.

Photo of Dr. Shaoyong Yu, M.D.

Associate Professor of Medicine


Dr. Shaoyong Yu is an Associate Professor of Medicine in the Division of Gastroenterology and Hepatology, Department of Medicine. His studies focus on neurogastroenterology and motility disorders.

Dr. Yu received medical and master’s degrees from Yichang and Tongji Medical Colleges, and a master of public health (MPH) degree from the Johns Hopkins Bloomberg School of Public Health.  Before joining the Johns Hopkins faculty, he completed three-year research fellowship training at Johns Hopkins University School of Medicine, focusing on gastrointeastinal motility disorders, plus an additional two-year postdoctoral training in sensory neurobiology at JHU. more


  • Associate Professor of Medicine



  • M.D., Yichang Medical College (China) (1986)

Additional Training

  • Johns Hopkins University School of Medicine, Division of Gastroenterology and Hepatology, Baltimore, MD, Clinical Research Fellow
  • Johns Hopkins University School of Medicine, Division of Allergy and Clinical Immunology, Baltimore, MD, Post-doctoral Fellow

Research & Publications

Research Summary

Dr. Yu's research has been focused on sensory afferent neurobiology and never-immune interactions in the GI tract. Specifically, he is interested in studying the cellular and molecular mechanisms underlying vagal afferent activation and mast cell activation-induced sensitization of visceral afferents in the GI tract.

For research inquiries please contact Dr. Yu via email at


The research projects in my lab focus on sensory neurobiology (vagal afferent function) in the gastrointestinal tract.

A post-doc position is opening to investigate the molecular and cellular mechanisms of visceral sensation and nociception for self-motivated individual who has been trained in electrophysiology (patch clamp and/or extra-cellular recording) and neuron imaging.

Technology Expertise Keywords

GI Physiology, Neurobiology, and Mucosal Immunology

Selected Publications

Yu S., Undem BJ, Kollarik M. Vagal afferent nerves with nociceptive properties in guinea-pig oesophagus. J Physiol. 2005;563(Pt 3):831-42.

Yu S, Gao GF, Peterson BZ, Ouyang A. TRPA1 in Mast Cell Activation-induced Long-lasting Mechanical Hypersensitivity of Vagal Afferent C fibers in Guinea Pig Esophagus. Am J Physiology Gastrointestinal & Liver. 2009;297(1):G34-42.

Yu XY, Hu Y, Yu S. Effects of Acid on Vagal Nociceptive Afferent Subtypes in Guinea Pig Esophagus. Am J Physiol Gastrointest Liver Physiol 2014, 307: G471-8.

Yu X, Hu Y, Ru F, Kollarik M, Undem BJ, Yu S. TRPM8 Function and Expression in Vagal Sensory Neurons and Afferent Nerves Innervating Guinea Pig Esophagus. Am J Physiol Gastrointest Liver Physiol. 2015, 308: G489-96.

Yu X, Patil MJ, Yu M, Liu Y, Wang J, Undem BJ, Yu S. Sphingosine-1-phosphate selectively activates vagal afferent C-fiber subtype in guinea pig esophagus. Neurogastroenterol Motil. 2018 Sep;30(9):e13359.

Contact for Research Inquiries

Phone: 410-502-2455

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