Dr. Yu's research has been focused on sensory afferent neurobiology and never-immune interactions in the GI tract. Specifically, he is interested in studying the cellular and molecular mechanisms underlying vagal afferent activation and mast cell activation-induced sensitization of visceral afferents in the GI tract.
For research inquiries please contact Dr. Yu via email at email@example.com.
The research projects in my lab focus on sensory neurobiology (vagal afferent function) in the gastrointestinal tract.
A post-doc position is opening to investigate the molecular and cellular mechanisms of visceral sensation and nociception for self-motivated individual who has been trained in electrophysiology (patch clamp and/or extra-cellular recording) and neuron imaging.
Technology Expertise Keywords
Esophageal Physiology, Vagal Afferent Neurobiology, and Mast Cell Biology
Liu Z, Hu Y, Yu X, Xi J, Fan X, Tse CM, Myers AC, Pasricha PJ, Li X, Yu S. Allergen challenge sensitizes TRPA1 in vagal sensory neurons and afferent C-fiber subtypes in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol. 2015 Mar 15;308(6):G482-8.
Yu X, Yu M, Liu Y, Yu S. TRP channel functions in the gastrointestinal tract. Semin Immunopathol. 2016 May;38(3):385-96.
Yu X, Patil MJ, Yu M, Liu Y, Wang J, Undem BJ, Yu S. Sphingosine-1-phosphate selectively activates vagal afferent C-fiber subtype in guinea pig esophagus. Neurogastroenterol Motil. 2018 Sep;30(9):e13359.
Hu Y, Yu X, Yu S. QX-314 inhibits acid-induced activation of esophageal nociceptive C fiber neurons. Neurogastroenterol Motil. 2019 Apr;31(4):e13543.
Huang Y, Patil MJ, Yu M, Liptak P, Undem BJ, Dong X, Wang G, Yu S. Effects of ginger constituent 6-shogaol on gastroesophageal vagal afferent C-fibers. Neurogastroenterol Motil. 2019 Apr 4:e13585.