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Mary Glenn Fowler, M.D., M.P.H.

Photo of Dr. Mary Glenn Fowler, M.D., M.P.H.
  • Professor of Pathology

Research Interests

Prevention and treatment of pediatric and HIV infection

Background

Dr. Mary Fowler is a professor of pathology at the Johns Hopkins University School of Medicine. She also has an appointment in the Johns Hopkins Bloomberg School of Public Health in the Department of International Health.

As a pediatrician and clinical researcher Dr. Fowler has devoted her career to prevention of mother to child transmission (PMTCT) and treatment and care of pediatric HIV infection.  Her research focuses on clinical trial strategies to reduce HIV transmission during pregnancy and breastfeeding, neurocognitive and growth outcomes of HIV exposed but uninfected children, bone health of HIV infected mothers on lifetime antiretrovirals and testing new antiretroviral drugs to prevent HIV among high risk but uninfected women. 

Dr. Fowler earned her M.D. from the University of Oregon and her M.P.H from the Johns Hopkins Bloomberg School of Public Health.  She worked at NIH and CDC conducting HIV related research before joining the  Johns Hopkins University School of Medicine Faculty in 2005.  

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Titles

  • Professor of Pathology

Departments / Divisions

Centers & Institutes

Research & Publications

Research Summary

Since the early 1990's Dr. Fowler has worked on a number of the key phase I-III perinatal and pediatric HIV treatment clinical trials conducted both in the U.S and in international settings. These include some of the early treatment trials of pediatric antiretrovirals as well as international trials for prevention of mother to child transmission of HIV (PMTCT) including the HIVNET 06 and 012 trials the PEPI infant prophylaxis trial, the Kisumu Infant Breastfeeding trial, Kesha Bora Trial in Nairobi, the HIVIGLOB/ SWEN trial, the HPTN 027 ALVAC perinatal vaccine trial, and the HPTN 046 trial of extended infant nevirapine infant prophylaxis.

Most recently Dr. Fowler has served as Chair of the NIH supported PROMISE trial (1077BF/1077FF), a large multisite PMTCT trial within the IMPAACT network assessing what the optimal strategies are for both PMTCT, safety and improving maternal and infant health. In addition, Dr. Fowler oversee studies of HIV primary prevention using microbicides and oral antiretroviral agents in Kampala Uganda at as part of the MTN network. These primary prevention trials include both young and older women, ages 18-49 who are at high risk for HIV acquisition.

Selected Publications

Jaco Homsy, Rachel King, Femke Bannink, Zikulah Namukwaya, Eric Vittinghof, Alexander Amone, Francis Ojok, Gordon Rukundo, Sharon Amama, Juliane Etima, Joyce Matovu, Fitti Weissglas, Lawrence Ojom, Pamela Atim, Lynae Darbes, Josaphat Byamugisha, George Rutherford, Elly Katabira, Mary Glenn Fowler, PRIMAL Study Team. Primary HIV Prevention Trial in pregnant and lactating Ugandan Women: A randomized Trial. PLoS one 2019; 14:e02129

MJ Boivin, L Maliwichi-Senganimalunje, L Wambuzin Ogwang, R Kawaliazira, A Sikorskii, I Familiar-Lopez, A Kuteesa, M Nyakato, A Mutebe, J L Namukooli, M Mallewa, H Ruisenor-Escudero, J Aizire, T Taha, MG Fowler. Developmental effects of antepartum and postpartum antiretroviral exposure for HIV-exposed versus HIV-unexposed uninfected children in Uganda and Malawi: a prospective cohort study. Lancet HIV: in press 2019.

PM Flynn, TE Taha, M Cababasay, MG Fowler et al. Prevention of HIV-1 Transmission through Breastfeeding: Efficacy and Safety of Maternal Antiretroviral Therapy Versus Infant Nevirapine Prophylaxis for Duration of Breastfeeding. JAIDS 77:383-392, 2018.

Hoffman RM, KN Angelidou, SS Brummel, F Saidi, A Violari, D Dula, V Mave, LFairlie, G Theron, M Kamateeka , T Chipato, D Bhattacharya, A Gupta, JA McIntyre, KL Klingman, N Chakhtoura, DE Shapiro, MG Fowler, JS Currier for the IMPAACT PROMISE 1077BF/FF team. Maternal health outcomes among HIV –infected breastfeeding women with high CD4 counts: results of a treatment strategy trial. HIV Clinical Trials 2018; 19: 209-224.

Fowler MG, Qin M, Currier JS, Flynn PM, Chipato T, McIntyre J, Gnanashanmugam D, Siberry GK, Coletti AS, Taha TE, Klingman KL, Martinson FE, Owor M, Volari A, Moodley D, Theron GV, Bhasole R, Bobat R, Chi BH, Strehlau R, Mlay P, Loftis AM, Browning R, Fenton T, Purdue L, Basar M, Shapiro DE, Mofenson LM, for the IMPAACT 1077BF/1077FF PROMISE Study Team. Benefits and risks of antiretroviral therapy for perinatal HIV prevention. N Eng J Med 2016; 375:1726-37.

Videos & Media

Recent News Articles and Media Coverage

Extended Interview: Dr. Mary Glenn Fowler, PBS NewsHour, November 6, 2003

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