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Angelika Doetzlhofer, Ph.D.
Research Interests: Hair cell regeneration; Hearing; Auditory development
Dr. Angelika Doetzlhofer is an assistant professor of neuroscience at the Johns Hopkins University School of Medicine. She serves on the faculty of the Johns Hopkins Center for Sensory Biology in the Institute for Basic Biomedical Sciences.
Dr. Doetzlhofer’s research primarily seeks to identify and characterize the molecular mechanisms of hair-cell development in the mammalian auditory system – and to identify the molecular roadblocks that prevent mammalian hair cells from regenerating. This work has important clinical potential for the treatment of patients who suffer from hearing and balance disorders.
She earned both a Ph.D. in molecular biology and an M.S. in biochemistry at the University of Vienna in Austria.
Dr. Doetzlhofer completed a seven-year post-doctoral fellowship in cell and molecular biology—and served as a senior research associate—at House Research Institute before joining the Johns Hopkins faculty in November 2008.
Postdoctoral fellow at House Research Institute, Los Angeles, CA (2007)
The Doetzlhofer Lab seeks to identify and characterize the molecular and cellular mechanisms that govern auditory sensory development and regeneration. The inner ear auditory sensory epithelium is critical for our ability to detect sound. Damage or loss to its mechano-sensory hair cells is permanent, leading to hearing deficits and deafness. However, in non-mammalian vertebrates, surrounding supporting cells undergo a process of de-differentiation after hair cell loss, and replace lost hair cells by either cell division or direct trans-differentiation.
Current research topics include:
Lab Website: Doetzlhofer Laboratory - Center for Sensory Biology
Campbell DP, Chrysostomou E, Doetzlhofer A. Canonical Notch signaling plays an instructive role in auditory supporting cell development. Sci Rep. 2016 Jan 20;6:19484. PMCID: PMC4726253.
Golden EJ, Benito-Gonzalez A, Doetzlhofer A. The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3864-73.PMCID: PMC4517247.
Benito-Gonzalez A, Doetzlhofer A. Hey1 and Hey2 control the spatial and temporal pattern of mammalian auditory hair cell differentiation downstream of Hedgehog signaling. J Neurosci. 2014 Sep 17;34(38):12865-76.PMCID:PMC4166165.
Korrapati S, Roux I, Glowatzki E, Doetzlhofer A. Notch signaling limits supporting cell plasticity in the hair cell-damaged early postnatal murine cochlea. PLoS One. 2013 Aug 30;8(8):e73276.PMCID: PMC3758270.
Doetzlhofer A, Basch ML, Ohyama T, Gessler M, Groves AK, Segil N. "Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti." Dev Cell. 2009 Jan;16(1):58-69. PMCID:PMC2696015.
White PM, Doetzlhofer A, Lee YS, Groves AK, Segil N. "Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells." Nature. 2006 Jun 22;441(7096):984-7.
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