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Acute Coronary Care, Acute Coronary Syndrome (ACS), Acute Myocardial Infarction (AMI), Angina, Angioplasty, Atherosclerosis, Cardiac Catheterization, Cardiac Disease, Cardiology, Cardiovascular Disease in Women, Cardiovascular Diseases, Cardiovascular Interventions, Cardiovascular Medicine, Chest Pain, Chronic Total Coronary Occlusion, Chronic Total Occlusions, Circulatory Support Devices, Clinical Cardiology, Coronary Angiography, Coronary Artery Disease, Coronary Artery Stenting, Dyslipidemia, Echocardiography, General Cardiology, Heart Attack, Heart Conditions, Heart Disease, Heart Disease Prevention and Treatment in Women, High Cholesterol, Hypertension, Interventional Cardiology, Invasive Cardiology, Ischemic Heart Disease, Laser Atherectomy, Myocardial Infarction, Percutaneous Coronary Intervention (PCI), Percutaneous Treatment of Valvular Stenosis, Pericardiocentesis, Peripheral Angiography, Premature Coronary Artery Disease, Right Heart Catheterization, Rotational Atherectomy, Stenting, Stress Testing, Stress-induced Cardiomyopathy, Trans-Radial Intervention, Transthoracic Echocardiogram, Treatment of Bypass Graft Disease with Distal Protection Devices, Valvular Heart Disease, Valvuloplasty for Valvular Stenosis ...read more
Active sensing drug delivery systems; Cell-based therapy for the heart and peripheral vasculature; Optimization of PCI and stent-based drug delivery using computational fluid dynamics; Pharmacologic Agents to Improve Outcome of PTCA and Stenting ...read more
Dr. Chao-Wei Hwang joined the Cardiology Faculty in 2011 and practices Interventional Cardiology at Johns Hopkins Hospital, Johns Hopkins Bayview Medical Center, Howard County General Hospital and Frederick Memorial Hospital. His area of research interest is in the design and development of active sensing drug delivery systems and local delivery systems for cell-based therapies to the heart.
1. Wan WK, Lovich MA, Hwang CW, Edelman ER. Measuring macromolecule distribution in vascular tissue using quantitative fluorescence microscopy. J Pharm Sci. 1999 Aug 2; 88(8):822-829.
2. Hwang CW, Wu D, Edelman ER. Stent-based delivery is associated with marked spatial variations in drug distribution. J Am Coll Cardiol. 2001 Feb;37(2) Supp A:1-2A.
3. Hwang CW, Wu D, Edelman ER. Physiological transport forces govern drug distribution for stent-based delivery. Circulation. 2001 Jul 31; 104(5): 600-605.
4. Lovich MA, Creel C, Hong K, Hwang CW, Edelman ER. Carrier proteins determine local pharmacokinetics and arterial distribution of Paclitaxel. J Pharm Sci. 2001 Sep; 90(9): 1324-1335.
5. Hwang CW and Edelman ER. Arterial ultrastructure influences transport of locally delivered drugs. Circ Res. 2002 Apr 19; 90(7): 826-832.
6. Janicki C, Hwang CW, Edelman ER. Dose model for stent-based delivery of a radioactive compound for the treatment of restenosis in coronary arteries. Med Phys. 2003 Oct; 30(10): 2622-2628.
7. Hwang CW, Wu D, Edelman ER. Impact of transport and drug properties on the local pharmacology of drug-eluting stents. Int J Cardiovasc Intervent. 2003; 5(1): 7-12.
8. Levin AD, Vukmirovic N, Hwang CW, Edelman ER. Specific binding to intracellular proteins determines arterial transport properties for Rapamycin and Paclitaxel. Proc Natl Acad Sci USA. 2004 Jun 22; 101(25):9463-7.
9. Saxena V, Hwang CW, Huang S, Eichbaum Q, Ingber D, Orgill D. Vacuum-Assisted Closure: Microdeformations of wounds and cell proliferation. Plast Reconstr Surg. 2004 Oct; 114(5):1086-1096.
10. Hwang CW, Levin AD, Jonas M, Li PH, Edelman ER. Thrombosis modulates arterial drug distribution for drug-eluting stents. Circulation. 2005 Apr 5; 111(13): 1619-1626.
11. Levin AD, Jonas M, Hwang CW, Edelman ER. Local and systemic drug competition in drug-eluting stent tissue deposition properties. J Control Release. 2005 Dec 5; 109(1-3):236-43.
12. Hwang CW and Edelman ER. Principles of continuum pharmacokinetics in stent-based drug elution, in Handbook of Drug-Eluting Stents, Serruys PW and Gershlick AH, eds. London, United Kingdom: Taylor & Francis Press, 2005: 47-56.
13. Le KN, Hwang CW, Tzafriri AR, Lovich MA, Edelman ER. Local therapeutic angiogenesis is limited by microvascular clearance. Circulation. 2008 Oct 28; 118(18), S457, Abstract 3642.
14. Le KN, Hwang CW, Tzafriri AR, Lovich MA, Hayward A, Edelman ER. Vascular regeneration by local growth factor release is self-limited by microvascular clearance. Circulation. 2009 Jun 9; 119(22): 2928-2935.
15. Blumenthal RS, Hwang CW, Nasir K. Selective use of coronary artery calcium screening: Worth the cost? J Am Coll Cardiol. 2009 Sep 29; 54(14): 1268-1270.
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