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Brian Hansen Ladle, M.D., Ph.D.

Photo of Dr. Brian Hansen Ladle, M.D., Ph.D.
  • Assistant Professor of Oncology


Medical Oncology, Pediatric Cancer, Pediatric Sarcoma

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The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-955-8751
1800 Orleans St.
The Charlotte R. Bloomberg Children's Center Building, 11th Floor
Baltimore, MD 21287 map
Phone: 443-287-2949



  • Assistant Professor of Oncology
  • Assistant Professor of Pediatrics

Departments / Divisions

Centers & Institutes



  • MD PhD, Johns Hopkins University School of Medicine (2007)


  • Cincinnati Childrens Hospital Medical Center / Pediatrics (2010)


  • Johns Hopkins University School of Medicine / Pediatric Hematology-Oncology (2013)
  • National Institutes of Health / Pediatric Hematology-Oncology (2014)

Additional Training

  • Maryland Medical License, Maryland Board of Physicians (2009)
  • Certification in Pediatrics, American Board of Pediatrics (2011)
  • Certification in Pediatric Hematology-Oncology, American Board of Pediatrics (2015)

Research & Publications

Selected Publications

A.M. Ercolini and B.H. Ladle (co-first authorship), E.A. Manning, L. Pfannenstiel, T.D. Armstrong, J.P.H. Machiels, J.G. Bieler, L.A. Emens, R.T. Reilly, E.M. Jaffee. Recruitment of latent pools of high avidity CD8+ T cells to the anti-tumor immune response. The Journal of Experimental Medicine. 2005 May 16;201(10):1591-602.

S. Murata, B.H. Ladle, P.S. Kim, E.R. Lutz, M.E. Wolpoe, S.E. Ivie, H.M. Smith, T.D. Armstrong, L.A. Emens, E.M. Jaffee, R.T. Reilly. OX40 Costimulation Synergizes with GM-CSF Whole-cell Vaccination to Overcome Established CD8+ T cell Tolerance to an Endogenous Tumor Antigen. The Journal of Immunology. 2006 Jan. 15; 176(2):974-83.

D.T. Le and B.H. Ladle (co-first authorship), T. Lee, V. Weiss, X. Yao, A. Leubner, T.D. Armstrong, E.M. Jaffee. CD8+ Foxp3+ tumor infiltrating lymphocytes accumulate in the context of an effective anti-tumor response. International Journal of Cancer. 2011 Aug 1;129(3):636-47.

R.M. Thomas, C.J. Gamper, B.H. Ladle, J.D. Powell, A.D. Wells. De novo DNA methylation is required to restrict T helper lineage plasticity. Journal of Biological Chemistry. 2012 Jun 29;287(27):22900-9.

Activities & Honors


  • American Society of Clinical Oncology, 2012
  • Children's Oncology Group, 2014
  • American Society for Pediatric Hematology/Oncology, 2015

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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