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Brian Hansen Ladle, M.D., Ph.D.

Photo of Dr. Brian Hansen Ladle, M.D., Ph.D.
  • Assistant Professor of Oncology


Medical Oncology, Pediatric Cancer, Pediatric Sarcoma

Research Interests

Translational immunology; Pediatric sarcomas; Immunotherapy

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The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-955-8751
1800 Orleans St.
The Charlotte R. Bloomberg Children's Center Building, 11th Floor
Baltimore, MD 21287 map
Phone: 443-287-2949


Dr. Brian Ladle is a pediatric cancer specialist in Baltimore, caring for patients with pediatric sarcoma. 

Dr. Ladle received his undergraduate degree in molecular biology from Brigham Young University. He earned his M.D. and Ph.D. degrees at the Johns Hopkins University School of Medicine. He completed his residency at Cincinnati Children’s Hospital Medical Center and performed a fellowship in pediatric hematology and oncology at Johns Hopkins and the National Institutes of Health. Dr. Ladle joined the Johns Hopkins faculty in 2013.

Dr. Ladle's research focuses on translational immunology, with the goal of developing novel immunotherapies for the treatment of pediatric malignancies. His lab currently focuses on augmenting anti-tumor T cell responses to solid tumors such as osteosarcoma, Ewing sarcoma and rhabdomyosarcoma.

He is a member of the American Association for Cancer Research, the American Society for Pediatric Hematology/Oncology, the American Society of Clinical Oncology and the Children's Oncology Group. more


  • Assistant Professor of Oncology
  • Assistant Professor of Pediatrics

Departments / Divisions

Centers & Institutes



  • MD PhD, Johns Hopkins University School of Medicine (2007)


  • Cincinnati Childrens Hospital Medical Center / Pediatrics (2010)


  • Johns Hopkins University School of Medicine / Pediatric Hematology-Oncology (2013)
  • National Institutes of Health / Pediatric Hematology-Oncology (2014)

Board Certifications

  • American Board of Pediatrics / Pediatric Hematology-Oncology (2015)
  • American Board of Pediatrics / Pediatrics (2011)

Additional Training

  • Maryland Medical License, Maryland Board of Physicians (2009)
  • Certification in Pediatrics, American Board of Pediatrics (2011)
  • Certification in Pediatric Hematology-Oncology, American Board of Pediatrics (2015)

Research & Publications

Research Summary

Dr. Ladle is a practicing pediatric oncologist and translational immunology researcher who has the goal of developing novel immunotherapies for the treatment of pediatric malignancies. His research seeks to understand mechanisms of immune tolerance in pediatric sarcomas and developing successful combination immunotherapies that will successfully treat sarcoma patients. He is working on translational projects combining immunotherapy with chemotherapy, epigenetic modifying agents and innate immune system adjuvants. Dr. Ladle has extensive expertise in immunology techniques – including both mouse and in vitro cell culture, multi-color flow cytometry and molecular techniques.

Clinical Trials

Nivolumab or Nivolumab and Azacitidine in Patients With Recurrent, Resectable Osteosarcoma

Selected Publications

R.M. Thomas, C.J. Gamper, B.H. Ladle, J.D. Powell, A.D. Wells. "De novo DNA methylation is required to restrict T helper lineage plasticity." Journal of Biological Chemistry. 2012 Jun 29;287(27):22900-9

D.T. Le and B.H. Ladle (co-first authorship), T. Lee, V. Weiss, X. Yao, A. Leubner, T.D. Armstrong, E.M. Jaffee. "CD8+ Foxp3+ tumor infiltrating lymphocytes accumulate in the context of an effective anti-tumor response." International Journal of Cancer. 2011 Aug 1;129(3):636-47.

A.M. Ercolini and B.H. Ladle (co-first authorship), E.A. Manning, L. Pfannenstiel, T.D. Armstrong, J.P.H. Machiels, J.G. Bieler, L.A. Emens, R.T. Reilly, E.M. Jaffee. "Recruitment of latent pools of high avidity CD8+ T cells to the anti-tumor immune response." The Journal of Experimental Medicine. 2005 May 16;201(10):1591-602.

S. Murata, B.H. Ladle, P.S. Kim, E.R. Lutz, M.E. Wolpoe, S.E. Ivie, H.M. Smith, T.D. Armstrong, L.A. Emens, E.M. Jaffee, R.T. Reilly. "OX40 Costimulation Synergizes with GM-CSF Whole-cell Vaccination to Overcome Established CD8+ T cell Tolerance to an Endogenous Tumor Antigen." The Journal of Immunology. 2006 Jan. 15; 176(2):974-83.

Academic Affiliations & Courses

Courses and Syllabi

  • Graduate Immunology Course, Lecturer, Johns Hopkins University School of Medicine

Activities & Honors


  • $1000 Presentation Award, Immuno-Oncology Young Investigator’s Forum, 2015
  • John G. Rangos, Sr. Medal of Honor in Creative Thinking, 2012
  • Optimist International Research Fellow, Sidney Kimmel Comprehensive Cancer Center, 2011
  • Blackfan Research Award, Cincinnati Children’s Hospital Medical Center, 2010
  • Turock Young Scientist Award, Johns Hopkins Institute of Basic Biomedical Sciences, 2003


  • American Association for Cancer Research, 2019
  • American Society for Pediatric Hematology/Oncology, 2015
  • Children's Oncology Group, 2014
  • American Society of Clinical Oncology, 2012

Professional Activities

  • Member, Protocol Committee, National Pediatric Cancer Foundation, 2018

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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