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Hilary Joyce Vernon, M.D., Ph.D.
Associate Professor of Pediatrics
Languages: English, Spanish
Research Interests: Molecular and metabolic pathogenesis of organic acidemias; Molecular and metabolic pathogenesis of Barth Syndrome; Clinical laboratory biochemical diagnosis ...read more
Dr. Hilary Vernon is an assistant professor of pediatrics at the Johns Hopkins University School of Medicine. She is also an attending physician at Kennedy Krieger Institute.
Dr. Vernon received her undergraduate degree in biochemistry from University of Pennsylvania. She earned her M.D. from Robert Wood Johnson Medical School/UMDNJ and her Ph.D. from Rutgers University. She completed a combined residency in pediatrics and clinical genetics and a fellowship in clinical laboratory biochemical genetics at Johns Hopkins University. Dr. Vernon joined the faculty at the Kennedy Krieger Institute and at Johns Hopkins University in 2011.
Her research focuses on inborn errors of metabolism, which cause disturbances of mitochondrial function, including several different organic acidemias and Barth Syndrome.
Dr. Vernon was recognized with the 2010 Francis F. Schwentker Award for Excellence in Research at Johns Hopkins University and the 2011 James B. Sidbury Jr. Fellowship in Biochemical Genetics at Johns Hopkins University. She is board certified in pediatrics, clinical genetics and clinical biochemical laboratory genetics.
- Associate Professor of Pediatrics
Centers & Institutes
- MD, Rutgers - Robert Wood Johnson Medical School (2004)
- Johns Hopkins University School of Medicine / Pediatrics (2011)
- Johns Hopkins University School of Medicine (2011)
- American Board of Medical Genetics and Genomics / Clinical Biochemical Genetics (2011)
- American Board of Medical Genetics and Genomics / Clinical Genetics / MD (2011)
- American Board of Pediatrics / Pediatrics (2009)
Research & Publications
Dr. Vernon's current area of study is in inborn errors of metabolism, which cause disturbances of mitochondrial function, including several different organic acidemias and Barth Syndrome. These are rare disorders, each with an approximate incidence of 1/50,000 - 1/250,000. They have an onset in childhood and a devastating effect on health and quality of life.
Dr. Vernon's lab uses a mass spectrometry-based metabolomics approach to create metabolic profiles of these disorders and select promising analytes from these profiles as potential treatment targets for further study. She is also using cell culture and animal-based models in identifying molecular and metabolic markers.
Selected PublicationsView all on Pubmed
Vernon H, Clark K, Bressler J. "In vitro models to study the blood brain barrier." Methods Mol Bio. 2011;758: 153-168.
Vernon HJ, Koerner CB, Johnson MR, Bergner A, Hamosh A. "Introduction of sapropterin dihydrochloride as standard of care in patients with phenylketonuria." Mol Genet Metab. 2010 Jul;100(3):229-33.
Vernon H, Osborne C, Tzortzaki E, Yang M, Chen J, Rittling S, Denhardt D, Buyske S, Bledsoe S, Evan A, Fairbanks L, Simmonds H, Tischfield J, Sahota A. "Aprt/Opn double knockout mice: Osteopontin is a modifier of kidney stone disease severity." Kidney International. 2005 Sep;68(3): 938-947.
Tinkel-Vernon H. Finkernagel S, Desposito F, Pittore C, Reynolds K, Sciorra L. "Patient With a Deletion of Chromosome 21q and Minimal Phenotype." American Journal of Medical Genetics. 2003 Jul 1;120: 142-143.
Krantz I, Smith R, Colliton R, Tinkel H., Zackai E, Piccoli D, Goldmuntz E, Spinner N. "Jagged1 Mutations in Patients Ascertained with Isolated Congenital Heart Defects." American Journal of Medical Genetics. 1999 May 7;84 (1): 56-60.
Vernon, H. "Dysmorphology." Oski's Pediatric Certification and Recertification Board Review. Eds. Coombs and Kirk. Lippincott Williams & Wilkins. 2010.
Vernon, H. "Metabolism." Oski's Pediatric Certification and Recertification Board Review. Eds. Coombs and Kirk. Lippincott Williams & Wilkins. 2010.
Tinkel-Vernon, H. "Allergy and Immunology." The Harriet Lane Handbook, 18th ed. Eds. Rau and Custer. Philadelphia, PA. 2009.
Tinkel-Vernon, H. "Human Genetics and Development." First Aid for the Pediatric Boards, 2nd ed. Eds: Le, Shroeder, Lam, Vera, Rabizadeh. New York, NY 2009.
Activities & Honors
- James B. Sidbury, Jr. Fellowship in Biochemical Genetics, Johns Hopkins University, 2011
- Francis F. Schwentker Award for Excellence in Research, Johns Hopkins University, 2010
- Chief resident of medical genetics, Institute of Genetic Medicine, Johns Hopkins University, 2010 - 2011
- Margaret Nielsen Fellowship in Genetic Medicine, Johns Hopkins Institute of Genetic Medicine, 2007
- Diplomate, American Board of Pediatrics, 2009
- Member, The American Society for Human Genetics, 1996