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Karthik S Suresh, M.D.

Photo of Dr. Karthik S Suresh, M.D.
  • Assistant Professor of Medicine
Male

Languages: English, Tamil

Expertise

Acute Lung Injury (ALI), Autoimmune Lung Disease, Lung Cancer, Pulmonary and Critical Care Medicine

Research Interests

ROS signaling; endothelial cell biology; vascular biology; calcium signaling

Locations

Johns Hopkins Bayview Medical Center

4940 Eastern Avenue
301 Building, 1st Floor
Baltimore, MD 21224 map
Phone: 410-955-9441

Johns Hopkins University

1830 E. Monument St.
Interstitial Lung Disease Clinic, 5th Floor
Baltimore, MD 21287 map
Phone: 410-955-4176

Background

Dr. Karthik Suresh is a pulmonary and critical care physician. His clinical interests include acute lung injury and critical care medicine. He also specializes in the diagnosis and management of immune-related lung injury, especially in the context of autoimmune conditions and chemotherapy/immunotherapy for cancer.

Dr. Suresh is a member of the Hopkins immune-related adverse events (irAE) tox team. He also takes care of critically ill patients in the medical and oncology ICUs. He’s a firm faculty member for the Janeway Firm of the Osler Housestaff Medical Service and provides teaching to medical students, housestaff and fellows.

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Titles

  • Assistant Professor of Medicine
  • Assistant Professor of Oncology

Departments / Divisions

Education

Degrees

  • MD, University of Louisville School of Medicine (2008)

Residencies

  • Johns Hopkins University School of Medicine / Internal Medicine (2011)

Fellowships

  • Johns Hopkins University School of Medicine / Pulmonary Medicine (2012)
  • Johns Hopkins University School of Medicine (2016)

Board Certifications

  • American Board of Internal Medicine / Internal Medicine (2011)
  • American Board of Internal Medicine / Pulmonary Disease (2015)

Research & Publications

Lab

The Suresh Lab is interested in several basic science and translational projects. Its primary research focus is the study of microvascular endothelial cell (MVEC) dysfunction in various lung diseases including acute lung injury (ALI) and pulmonary arterial hypertension (PAH).

The lab is specifically interested in the role of mitochondria-derived reactive oxygen species (mtROS) and calcium signaling in promoting MVEC dysfunction in ALI and PAH; using animal models of these diseases as well as cells isolated from animal and humans. The lab studies the links between mtROS, calcium levels and mitochondrial structure/function with the goal of understanding the mechanisms driving mitochondrial and cellular dysfunction in lung MVECs.

Related to this project, in collaboration with the Izumchenko lab in Otolaryngology, the lab also employs computational approaches to discover somatic mutations in mitochondrial DNA with a goal of studying the effects of oxidant stress on induction of somatic mtDNA mutations in non-cancerous pathologies such as PAH.

Lastly, in collaboration with the D’Alessio Lab, the lab is conducting translational studies exploring mechanisms of lung injury in patients who develop pneumonitis after receiving immunotherapy.

Clinical Trial Keywords

ROS signaling, calcium signaling, microvascular endothelial cell physiology, mitochondrial structure/function, mechanisms of immunotherapy toxicity

Clinical Trials

 Optimization of steroid-refractory immune checkpoint inhibitors; Therapeutic options for autoimmune-associated interstitial lung disease

Contact for Research Inquiries

Johns Hopkins Asthma and Allergy Center
5501 Hopkins Bayview Circle
Rm 4B.32A
Baltimore, MD 21224 map

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Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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