The Suresh Lab is interested in several basic science and translational projects. Its primary research focus is the study of microvascular endothelial cell (MVEC) dysfunction in various lung diseases including acute lung injury (ALI) and pulmonary arterial hypertension (PAH).
The lab is specifically interested in the role of mitochondria-derived reactive oxygen species (mtROS) and calcium signaling in promoting MVEC dysfunction in ALI and PAH; using animal models of these diseases as well as cells isolated from animal and humans. The lab studies the links between mtROS, calcium levels and mitochondrial structure/function with the goal of understanding the mechanisms driving mitochondrial and cellular dysfunction in lung MVECs.
Related to this project, in collaboration with the Izumchenko lab in Otolaryngology, the lab also employs computational approaches to discover somatic mutations in mitochondrial DNA with a goal of studying the effects of oxidant stress on induction of somatic mtDNA mutations in non-cancerous pathologies such as PAH.
Lastly, in collaboration with the D’Alessio Lab, the lab is conducting translational studies exploring mechanisms of lung injury in patients who develop pneumonitis after receiving immunotherapy.
Clinical Trial Keywords
ROS signaling, calcium signaling, microvascular endothelial cell physiology, mitochondrial structure/function, mechanisms of immunotherapy toxicity
Optimization of steroid-refractory immune checkpoint inhibitors; Therapeutic options for autoimmune-associated interstitial lung disease