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School of Medicine
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Karthik S Suresh, M.D.
Assistant Professor of Medicine
Languages: English, Tamil
Expertise: General Internal Medicine
Research Interests: ROS signaling; endothelial cell biology; vascular biology; calcium signaling
Dr. Karthik Suresh is an assistant professor of medicine at the Johns Hopkins University School of Medicine. His areas of clinical interest and expertise include general internal medicine, pulmonary / critical care medicine and pulmonary complications of chemo/immunotherapy.
He earned his B.S. and M.D. from the University of Louisville School of Medicine. He completed his residency at the Osler Medicine training program at Johns Hopkins, and performed a fellowship in Pulmonary / Critical Care Medicine at Johns Hopkins.
- Assistant Professor of Medicine
- MD, University of Louisville School of Medicine (2008)
- Johns Hopkins University School of Medicine / Internal Medicine (2011)
- Johns Hopkins University School of Medicine / Pulmonary Medicine (2012)
- Johns Hopkins University School of Medicine (2016)
- American Board of Internal Medicine / Internal Medicine (2011)
Research & Publications
Our lab focuses on three major topics focused around mechanisms of microvascular endothelial cell (MVEC) dysfunction in the lung: ROS-induced Ca2+ signaling; mechanisms of checkpoint inhibitor toxicity; and MVEC mitochondrial structure/function/genomics
1. ROS-induced Ca2+ influx: Using endothelial cells (ECs) isolated from humans, mice and rats, as well as animal models of ALI and PAH, we investigate the role of elevated reactive oxygen species (ROS) and intracellular calcium in regulating disease-specific abnormalities in EC function. In ALI, we study signaling pathways governing formation of paracellular gaps between endothelial cells, which clinically leads to alveolar flooding and hypoxemia. For PAH, we study the effect of ROS and calcium signaling on EC migration and proliferation as it relates to formation of vaso-occlusive lesions in the distal arterioles of the lung, a known contributor to elevations in pulmonary artery pressures in this disease.
2. Mechanisms of checkpoint inhibitor toxicity: In collaboration with Dr. Jarushka Naidoo (Oncology) and Dr. Franco D'Alessio (Pulm/CC), we study clinical characteristics and biologic mechanisms of lung injury in patients who develop pneumonitis after receiving immune checkpoint inhibitors (ICIs) - termed checkpoint inhibitor pneumonitis (CIP). We are specifically interested in mechanisms of endothelial leak and alveolar inflammatory cell efflux in CIP.
3. Mitochondrial structure/function/genomics in PAH: We are interested in the impact of abnormal mitochondrial structure (e.g. increased fragmentation), function (changes in respiration and metabolism) and genomics (induction of somatic mutations) on cytosolic Ca2+ levels and promotion of abnormal MVEC behavior (EndMT, migration, proliferation) in PAH.
Clinical Trial KeywordsROS signaling, calcium signaling, microvascular endothelial cell physiology, mitochondrial structure/function, mechanisms of immunotherapy toxicity
Optimization of steroid-refractory immune checkpoint inhibitors; Therapeutic options for autoimmune-associated interstitial lung disease
Suresh K, Servinsky LE, Reyes J, Baksh S, Undem C, Caterina MJ, Pearse DB, Shimoda LA. Hydrogen Peroxide-induced Calcium Influx in lung microvascular endothelial cells involves TRPV4. Am J Physiol Lung Cell Mol Physiol. 309: L1467–L1477, 2015 (Editor's Pick)
Suresh K, Servinsky LE, Reyes J, Undem C, Zaldumbide J, Rentsendorj O, Modekurty S, Dodd-o J, Pearse DB, Shimoda LA. CD36 mediates H2O2-induced calcium influx in lung microvascular endothelial cells Am J Physiol Lung Cell Mol Physiol. 312: L143-153, 2016
Suresh K, Servinsky L, Jiang H, Bigham Z, Huetsch J, Kliment C, Damarla M, Shimoda LA "ROS-induced Ca2+ via TRPV4 and microvascular endothelial dysfunction in the SU5416/Hypoxia model of pulmonary arterial hypertension", Am J Physiol Lung Cell Mol Physiol. 2018 [Epub ahead of print]
Suresh K, Zhong Q, Voong R, Ettinger D, Marrone K, Kelly R, Hahn C, Levy B, Feliciano J, Brahmer J, Forde P, Feller-Kopman D, Lerner A, Lee H, Yarmus L, D'Alessio F, Danoff S, Naidoo J. Clinical Features and Bronchoalveolar Lavage Characteristics Of PD-1 Pneumonitis In Lung Cancer Patients Receiving Checkpoint Immunotherapy, J. Thoracic Onc. [Epub ahead of print]. 2018
Suresh K, Naidoo J., Lin T, Danoff S. Pulmonary complications of immune checkpoint inhibitor therapy: benefits and risks. CHEST [epub ahead of print]. 2018
Contact for Research Inquiries
Research Lab: Johns Hopkins Bayview
Asthma and Allergy Building, 4th floor
Baltimore, MD 21224 map