Dr. Zhou's research focuses on developing new methodologies of in vivo magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) to study brain function and various human diseases, such as brain tumor and stroke. His most recent work includes absolute quantification of cerebral blood flow, quantification of functional MRI, magnetization transfer mechanism, development of chemical exchange saturation transfer (CEST) technology, brain pH MR imaging, tissue protein MR imaging, and high-resolution diffusion tensor imaging (DTI). A major part of his current research is in vivo imaging of experimental brain tumor models and clinical imaging of brain tumor patients using a new MRI technique, the amide proton transfer (APT) imaging. The overall goal is to achieve the MRI contrast at the protein and peptide level without injection of exogenous agents and to improve the diagnostic capability of MRI and the patient outcome.
Lab Website: Jinyuan Zhou Lab
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Jinyuan Zhou, Jean-Francois Payen, David A. Wilson, Richard J. Traystman, and P. C. M. van Zijl. Using the Amide Proton Signals of Intracellular Proteins and Peptides to Detect pH Effects in MRI. Nature Med. 9, 1085-1090 (2003)
Jinyuan Zhou, Jaishri O. Blakeley, Jun Hua, Mina Kim, John Laterra, Martin G. Pomper, and Peter C. M. van Zijl. A Practical Data Acquisition Method for Human Brain Amide Proton Transfer (APT) Imaging. Magn. Reson. Med. 60, 842-849 (2008). PMC2579754
Jinyuan Zhou, Erik Tryggestad, Zhibo Wen, Bachchu Lal, Tingting Zhou, Rachel Grossman, Kun Yan, Silun Wang, De-Xue Fu, Jaishri Blakeley, Eric Ford, Betty Tyler, John Laterra, and Peter C.M. van Zijl. Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nature Med. 17, 130-134 (2011). PMC3058561
Jinyuan Zhou, He Zhu, Michael Lim, Lindsay Blair, Alfredo Quinones-Hinojosa, Steven A. Messina, Charles Eberhart, Martin Pomper, John Laterra, Peter B. Barker, Peter C.M. van Zijl, and Jaishri Blakeley. Three-Dimensional Amide Proton Transfer MR Imaging of Gliomas: Initial Experience and Comparison with Gadolinium Enhancement. J. Magn. Reson. Imaging. 38, 1119-1128 (2013). PMC3664658
Xiaohua Hong, Li Liu, Meiyun Wang, Kai Ding, Ying Fan, Bo Ma, Bachchu Lal, Betty Tyler, Antonella Mangraviti, Silun Wang, John Wong, John Laterra, Jinyuan Zhou. Quantitative Multi-parametric MRI Assessment of Glioma Response to Radiotherapy in a Rat Model. Neuro-Oncology. 16, 856-867 (2014). PMC4022217.