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R. Scott Stephens, M.D.

Robert Scott Stephens, M.D.

Director, Oncology and Bone Marrow Transplant Critical Care
Assistant Professor of Medicine

Male

Expertise

Acute Respiratory Distress Syndrome (ARDS), Cardiac Disease, Pulmonary and Critical Care Medicine, Septic Shock

Research Interests

Acute Respiratory Distress Syndrome; Pulmonary Endothelial Barrier Function; Extracorporeal Membrane Oxygenation; Pulmonary Endothelial Antioxidant Regulation; Acute Respiratory Failure; Critical Care Education ...read more

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410-955-3467

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410-464-6641

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+1-410-502-7683

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Locations

The Johns Hopkins Hospital

Appointment Phone: 410-955-3467

1830 E. Monument Street
1830 Building 5th Floor Pulmonary
Baltimore, MD 21287 map

Phone: 410-550-0545

Johns Hopkins Bayview Medical Center

5501 Hopkins Bayview Circle
Asthma and Allergy Center
Baltimore, MD 21224 map

Phone: 410-550-0545 | Fax: 410-550-2612

Background

Dr. R. Scott Stephens is an assistant professor of medicine at the Johns Hopkins University School of Medicine. His expertise is in critical care medicine, with a focus on severe acute respiratory distress syndrome (ARDS), refractory circulatory shock, acute respiratory failure after hematopoietic stem cell transplant, and extracorporeal membrane oxygenation (ECMO) for respiratory and circulatory failure.

Dr. Stephens has additional extensive experience in the management of septic shock, neutropenic sepsis, life-threatening oncologic complications, pulmonary embolism, and other common critical care conditions. He also has expertise in cardiac surgical critical care, including the immediate post-operative management of coronary and cardiac valve surgery patients as well as the critical care of heart transplant, lung transplant and ventricular assist devices.

Dr. Stephens leads the Advanced Critical Care Clerkship for fourth-year medical students. He was recognized by the Johns Hopkins Institute for Excellence in Education with an Outstanding Achievement in Education Award (Educational Program) in 2013. He is a member of American Thoracic Society and the American Physiologic Society.

Titles

Director, Oncology and Bone Marrow Transplant Critical Care
Assistant Professor of Medicine
Assistant Professor of Oncology

Departments / Divisions

Medicine - Pulmonary and Critical Care Medicine
Medicine - Pulmonary and Respiratory
Medicine - Pulmonary Medicine
Oncology - Hematologic Malignancies

Centers & Institutes

Heart and Vascular Institute

Education

Degrees

MD, University of Pennsylvania School of Medicine (2003)

Residencies

Johns Hopkins University School of Medicine / Medicine (2006)

Fellowships

Johns Hopkins University School of Medicine / Pulmonary Medicine (2010)

Board Certifications

American Board of Internal Medicine / Critical Care Medicine (2011)
American Board of Internal Medicine / Pulmonary Disease (2010)

Research & Publications

Research Summary

Dr. Stephens was trained as a basic scientist studying acute lung injury and the role of protein kinase G and c-Abl kinase-mediated signaling in lung endothelial antioxidant regulation.

He has recently shifted his focus to clinical and translational research in acute respiratory failure, and has two primary areas of interest. The first lies in the management of severe ARDS, with particular focus on the role of advanced modalities such as ECMO. His second research focus is in acute respiratory failure after bone marrow transplant, particularly non-myeloablative haploidentical bone marrow transplantation.

He is an active participant in the Society of Critical Care Medicine Discovery Research Network (formerly the United States Critical Illness and Injury Trials Group), and is a member of the steering committee of the Discovery-Program in Emergency Preparedness (PREP). In addition, he is a member of the North American ECMO Research Network and is on the executive committee of the Oncology Critical Care Research Network (ONCCC-R-NET).

Selected Publications

Stephens RS. "Invited commentary." Ann Thorac Surg. 2015 Feb;99(2):595-6. doi: 10.1016/j.athoracsur.2014.09.031.

Stephens RS, Servinsky LE, Rentsendorj O, Kolb TM, Pfeifer A, Pearse DB. "Protein kinase G increases antioxidant function in lung microvascular endothelial cells by inhibiting the c-Abl tyrosine kinase." Am J Physiol Cell Physiol. 2014 Mar 15;306(6):C559-69. doi: 10.1152/ajpcell.00375.2012. Epub 2014 Jan 8.

Stephens R, Fan E. "Choosing wisely - when to mend a broken heart with ECMO?" Crit Care. 2014 Feb 20;18(1):112. doi: 10.1186/cc13736.

Kim, BS, Serebreni, L, Hamdan, O, Wang, L, Parniani, A, Sussan, T, Stephens, RS, Boyer, L, Damarla, M, Hassoun, PM, and Damico, R. "Xanthine oxidoreductase is a critical mediator of cigarette smoke-induced endothelial cell DNA damage and apoptosis." Free Radical Biology and Medicine. 2013 Jul;60:336-46. doi: 10.1016/j.freeradbiomed.2013.01.023. Epub 2013 Feb 4.

Stephens RS, Shah AS, Whitman GJ. "Lung injury and acute respiratory distress syndrome after cardiac surgery." Ann Thorac Surg. 2013 Mar;95(3):1122-9. doi: 10.1016/j.athoracsur.2012.10.024. Epub 2013 Jan 23.

Rahimi RA, Skrzat J, Reddy DR, Zanni JM, Fan E, Stephens RS, Needham DM. "Physical rehabilitation of patients in the intensive care unit requiring extracorporeal membrane oxygenation: a small case series." Phys Ther. 2013 Feb;93(2):248-55. doi: 10.2522/ptj.20120336. Epub 2012 Oct 25.

Anidi IU, Servinsky LE, Rentsendorj O, Stephens RS, Scott AL, Pearse DB. "CD36 and Fyn kinase mediate malaria-induced lung endothelial barrier dysfunction in mice infected with Plasmodium berghei." PLoS One. 2013 Aug 15;8(8):e71010. doi: 10.1371/journal.pone.0071010. eCollection 2013.

Stephens, RS, Rentsendorj, O, Servinsky, LE, Moldobaeva, A, Damico, R, Pearse DB. "cGMP increases anti-oxidant function and attenuates oxidant cell death in mouse lung microvascular endothelial cells by a protein kinase G-dependent mechanism." Am J Physiol Lung Cell Mol Physiol. 2010 Sep;299(3):L323-33. doi: 10.1152/ajplung.00442.2009. Epub 2010 May 7.

Petrache, I, Diab, K, Knox, KS, Twigg, HL, Stephens, RS, Flores, S, Tuder, RM. "HIV-associated pulmonary emphysemia: a review of the literature and an inquiry into its mechanism." Thorax. 2008 May;63(5):463-9. doi: 10.1136/thx.2007.079111.

Moldobaeva A, Welsh-Servinsky LE, Shimoda LA, Stephens RS, Verin AD, Tuder RM, Pearse DB. "Role of protein kinase G in barrier-protective effects of cGMP in human pulmonary artery endothelial cells." Am J Physiol Lung Cell Mol Physiol. 2006 May;290(5):L919-30. Epub 2005 Dec 9.

Stephens, R.S., Shah, A.S., and Whitman, G.J.R. Should we prone cardiac surgical patients with severe acute respiratory distress syndrome (reply)? Annals of Thoracic Surgery 2014. 97(3): 1122-3.

Kim, BS, Serebreni, L, Hamdan, O, Wang, L, Parniani, A, Sussan, T, Stephens, RS, Boyer, L, Damarla, M, Hassoun, PM, and Damico, R. Xanthine Oxidoreductase is a Critical Mediator of Cigarette Smoke-Induced Endothelial Cell DNA Damage and Apoptosis. Free Radical Biology and Medicine 2013. 60: 336-46.

Stephens RS, Shah AS, Whitman GJ. Lung injury and acute respiratory distress syndrome after cardiac surgery. Ann Thorac Surg. 2013 Mar;95(3):1122-9. doi: 10.1016/j.athoracsur.2012.10.024. Epub 2013 Jan 23. Review. PMID: 23352419

Kinnery, P., Pick, J., Stephens, S., Jain, D., Solomides C.S., Niven, R., Segal, R., Christofidou-Solomidou, M. (2006). KL4-Surfactant prevents Hyperoxic and LPS-Induced Lung Injury in Mice. Pediatric Pulmonology. 41(10):916-28.

Stephens, S., Beyer, B., Balthazar-Stablein, U., Duncan, R., Kostacos, M., Lukoma, M, Green, G.R., and Poccia, D. (2002). Two Kinase Activities are Sufficient for Sea Urchin Sperm Chromatin Decondensation in Vitro. Molecular Reproduction and Development.62: 496-503.

Stephens, R.S. and Whitman, G.J.R. (2015). Post-Operative Critical Care of the Adult Cardiac Surgical Patient. Part 1: Routine Post-Operative Care. Critical Care Medicine. 43(7): 1477-97.

Stephens, R.S. and Whitman, G.J.R. Post-Operative Critical Care of the Adult Cardiac Surgical Patient. Part 2: Procedure-Specific Considerations, Management of Complications, and Quality Improvement. Critical Care Medicine. 43(9):1995-2014

Wachtel, L. Commins, E., Park, M., Rolider, N., Stephens, R., and Reti, I. (2015). Neuroleptic malignant syndrome and delirious mania as malignant catatonia in autism: prompt relief with electroconvulsive therap. Acta Psychiatr Scand. May 28 2015. Epub ahead of print. PMID: 26018851

Crawford, T.C., Grimm, J., Magruder, J.T., Stephens, R.S., Sciortino, C., Vaught, J., Althaus, J., Shah, A., Kim, B. (2015). A Curious Case of Acute Respiratory Distress Syndrome. Journal of Surgical Case Reports. 11; 1-3.

Stephens, R.S., Johnston, L., Servinsky, L., Kim, B., and Damarla, M. (2015). The Tyrosine Kinase Inhibitor Imatinib Prevents Lung Injury and Death after Intravenous LPS in Mice. Physiological Reports. In Press.

Academic Affiliations & Courses

Courses and Syllabi

“Advanced Critical Care Clerkship,” Genes to Society: A Curriculum for the Johns Hopkins University School of Medicine

Activities & Honors

Honors

Outstanding Achievement in Education Award (Educational Program), Johns Hopkins Institute for Excellence in Education, 2013

Memberships

American Physiologic Society
American Thoracic Society

Professional Activities

Director, Advanced Critical Care Clerkship, Johns Hopkins, Baltimore, MD
Co-Director, Fellowship Program in Pulmonary and Critical Care Medicine, Johns Hopkins, Baltimore, MD

Videos & Media

Lectures and Presentations

“Pulmonary and Critical Care Medicine”
Grand Rounds Program, Johns Hopkins Community Grand Rounds Program

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The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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