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Neal S. Fedarko, Ph.D.

Photo of Dr. Neal S. Fedarko, Ph.D.
  • Director, Clinical Research Core Laboratory, Institute for Clinical & Translational Research
  • Professor of Medicine

Research Interests

The overall focus has been on extracellular signal transduction and homeostasis; usually in the context of aging and/or cancer. ...read more

Background

Dr. Neal Fedarko is a Professor of Medicine in the Geriatric Medicine and Gerontology division. He studies aging-related dysregulation of signal transduction and cellular differentiation.

Dr. Fedarko holds a bachelor's degree from Oberlin College and a PhD from the University of Illinois at Champaign-Urbana. He completed a postdoctoral fellowship at the National Institutes of Health before joining the Johns Hopkins faculty in 1992.
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Titles

  • Director, Clinical Research Core Laboratory, Institute for Clinical & Translational Research
  • Co-Director, Fellowship Training Program in Gerontology and Geriatrics
  • Co-Director, Biology of Healthy Aging Program, Johns Hopkins School of Medicine
  • Professor of Medicine

Departments / Divisions

Centers & Institutes

Education

Additional Training

National Institutes of Health, Postdoctoral Fellowship; National Institutes of Health, Postdoctoral Fellowship

Research & Publications

Research Summary

Research has involved both basic and clinical studies focused on the biochemical and biological actions of a gene family we first described in 2001 (the SIBLING or Small Integrin Binding LIgand N-linked Glycoprotein family). The research has shown that SIBLINGs are secreted intrinsically disordered proteins that bind multiple partners and modulate their partner’s normal biological activity. SIBLINGs are induced in different cancers where their actions facilitate tumor cell enhanced invasiveness and evasion of immune surveillance. The diagnostic utility of SIBLINGs has been studied through developing competitive and sandwich based ELISAs for their quantitative measurement.

Aging-specific research has involved developing biomarkers for sentinel homeostatic pathways such as inflammation (neopterin), senescence (chitotriosidase) and apoptosis (sFas, cytochrome C) to assess phenotypic consequences of altered extracellular signaling. The impact of aging and autoimmunity on signal transduction has been investigated by studying agonistic autoantibodies against the angiotensin II type 1 receptor. These autoantibodies activate their target receptor promoting chronic inflammation and are associated with at-risk status in older adults. Current studies are focused on whether the autoantibodies are predictive of time to diagnosis and time to death in cancer and other diseases associated with a high chronic inflammatory burden.

Technology Expertise Keywords

Biomarkers; Immunoassays; High Performance Liquid Chromatography; Tissue Culture; Pre-clinical Mouse Models

Contact for Research Inquiries

Fedarko Lab
5501 Hopkins Bayview Circle
Room 1A-12 JHAAC
Baltimore, MD 21224 map

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