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Nirmish Singla, M.D., M.Sc.

Photo of Dr. Nirmish Singla, M.D., M.Sc.
  • Director of Translational Research in GU Oncology
  • Assistant Professor of Urology

Languages: English, Hindi, Spanish

Expertise

Active Surveillance for Kidney Cancer, Active Surveillance of Prostate Cancer, Adrenal Cancer, Adrenal Surgery, Adrenalectomy, Bladder Cancer, Cytoreductive Nephrectomy, Genitourinary Sarcoma, Inferior Vena Cava (IVC) Thrombectomy, Inguinal Lymph Node Dissection, Kidney Cancer, Laparoscopic Adrenalectomy, Laparoscopic Kidney Surgery, Laparoscopic Nephrectomy, Laparoscopic Radical Nephrectomy, Nephron Sparing Surgery, Nephroureterectomy, Open Partial Nephrectomy, Partial Nephrectomy, Penile Cancer, Prostate Cancer, Radical Nephrectomy, Radical Orchiectomy, Retroperitoneal Lymph Node Dissection, Robotic Adrenalectomy, Robotic Cystectomy, Robotic Nephrectomy, Robotic Partial Nephrectomy, Robotic Prostatectomy, Robotic RPLND, Testicular Cancer, Transurethral Resection of Bladder Tumor, Upper Tract Urothelial Cancer, Urethral Cancer, Urologic Surgery, Urology ...read more

Research Interests

Urologic Malignancies; Precision Oncology; Multimodal Treatment; Kidney Cancer; Renal Cell Carcinoma, Testicular Cancer; Upper Tract Urothelial Carcinoma; Translational Research; Clinical Trials; Biomarker Discovery ...read more

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Insurance Information

Maryland

410-955-6100

Outside of Maryland

410-464-6641
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International Patients

+1-410-502-7683
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Locations

The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-955-6100
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-502-3692 | Fax: 410-955-0833

Johns Hopkins Outpatient Center

Appointment Phone: 410-955-6100
601 N. Caroline St.
Baltimore, MD 21287 map
Phone: 410-502-3692 | Fax: 410-955-0833

Johns Hopkins Medicine - Green Spring Station

Appointment Phone: 410-955-6100
10803 Falls Road
Pavilion III, Suite 3300
Lutherville, MD 21093 map
Phone: 410-616-7600 | Fax: 410-955-0833

Background

Dr. Nirmish Singla is an Assistant Professor of Urology and Oncology in the Brady Urological Institute at Johns Hopkins University.  He serves as the Director of Translational Research in Genitourinary Oncology and helps lead the multidisciplinary Kidney Cancer Program at Johns Hopkins.

Dr. Singla received his undergraduate degree (B.S.E.) in Biomedical Engineering from the University of Michigan and his medical degree (M.D.) from the University of Michigan Medical School, where he was supported by a full-tuition Dean’s Merit Scholarship.  While there, he worked in the renowned laboratory of Dr. Arul Chinnaiyan to identify urinary biomarkers in prostate cancer using gene fusions.  He went on to complete his residency training in Urologic Surgery at the University of Texas Southwestern Medical Center (UTSW), where he served as Administrative Chief Resident.  Following his residency, he received an NIH/NCI Ruth L. Kirschstein National Research Service Award T32 grant and spent an additional year at UTSW as a postdoctoral research fellow in Urologic Oncology through the Physician Scientist Training Program.  During this time, he earned a Master of Science in Clinical Science (M.S.C.S.) degree through the Center for Translational Medicine at UTSW and helped develop and pioneer a Physician Administrative Fellowship program.  He then completed a specialized clinical fellowship in urologic oncology at Memorial Sloan Kettering Cancer Center (MSKCC) in New York through the Society of Urologic Oncology (SUO) before joining Johns Hopkins.

During his advanced surgical training in complex urologic oncology at MSKCC, Dr. Singla gained clinical expertise in all areas of urologic oncology, including adrenal, kidney, upper tract, bladder, prostate, penile, urethral, and testicular cancers.  Dr. Singla’s clinical practice spans the complete spectrum of genitourinary oncology and includes mastery of both open and minimally-invasive (endoscopic, laparoscopic, and robotic) techniques.  Dr. Singla strives to provide personalized and compassionate care for patients affected by urologic cancer by integrating cutting-edge technologies and multidisciplinary approaches to treatment.

Dr. Singla has been intimately involved in basic, translational, clinical, and engineering research endeavors across all urologic malignancies.  He has a specialized clinical and translational research interest in kidney cancer.  While at UTSW, he became integrated into their renowned, multidisciplinary Kidney Cancer Program, which is one of only two programs in the country to receive a multimillion-dollar Specialized Programs of Research Excellence (SPORE) grant from the NCI for Kidney Cancer.  In particular, Dr. Singla is interested in studying the biology of kidney cancer on a molecular level, focusing on prognostication in localized and advanced disease, identifying diagnostic and therapeutic targets, understanding mechanisms of therapeutic resistance, and designing multidisciplinary clinical trials to reduce morbidity, personalize treatment, and improve outcomes in patients.  He has directly mentored several students, residents, and fellows in both clinical and translational research pursuits.

As the Director of Translational Research in GU Oncology at Johns Hopkins, Dr. Singla’s overarching goal is to help scientific discoveries in the laboratory materialize for patients with urologic cancers in the clinic.  His primary focus is to help build and lead a multidisciplinary clinical and translational Kidney Cancer Program at Johns Hopkins.  He also shares clinical and research interests in testicular, prostatic, and urothelial malignancies, including upper tract urothelial carcinoma.  Prior to joining Johns Hopkins, Dr. Singla co-authored >150 articles, 10 book chapters, and >230 local, national, or international presentations.  He serves as an ad hoc reviewer for multiple renowned urologic journals and has earned numerous awards and national recognition for his academic work.

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Titles

  • Director of Translational Research in GU Oncology
  • Assistant Professor of Urology

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MD, University of Michigan Medical School (2013)

Residencies

  • University of Texas Southwestern Medical Center / Urology (2018)

Fellowships

  • Memorial Sloan-Kettering Cancer Center / Urologic Oncology (2020)

Board Certifications

  • Pending/Scheduled / Urology

Research & Publications

Selected Publications

View all on Pubmed

Singla N, Xie Z, Zhang Z, Gao M, Yousuf Q, Onabolu O, McKenzie T, Tcheuyap VT, Ma Y, Choi J, McKay R, Christie A, Torras OR, Bowman IA, Margulis V, Pedrosa I, Przybycin C, Wang T, Kapur P, Rini B, Brugarolas J. Pancreatic tropism in metastatic renal cell carcinoma. JCI Insight 5(7): e134564, 2020

Singla N. Progress toward precision medicine in frontline treatment of metastatic renal cell carcinoma. In press, JAMA Oncology

Singla N. A new therapeutic era for metastatic renal cell carcinoma: Call for a new prognostic model. In press, JAMA Oncology

Singla N, Margulis V, on behalf of ECOG-ACRIN 8141 Investigators. A new standard for a rare disease? Optimizing the timing of chemotherapy for upper tract urothelial carcinoma. "Re: Alison Birtle, Mark Johnson, John Chester, et al. Adjuvant Chemotherapy in Upper Tract Urothelial Carcinoma (the POUT Trial): A Phase 3, Open-label, Randomised Controlled Trial. Lancet 2020;395:1268-77." In press, European Urology

Lafin JT*, Singla N*, Woldu SL, Lotan Y, Lewis CM, Majmudar K, Savelyeva A, Kapur P, Margulis V, Strand DW, Murray MJ, Amatruda JF, Bagrodia A. Serum microRNA-371a-3p levels predict viable germ cell tumor in chemotherapy-naïve patients undergoing retroperitoneal lymph node dissection. European Urology 77(2): 290-292, 2020

*Co-first authors

Activities & Honors

Honors

  • Merit Award, Genitourinary Cancers Symposium, Conquer Cancer Foundation of the American Society of Clinical Oncology (ASCO): “Serum microRNA-371a-3p levels predict viable germ cell tumor in chemotherapy-naïve patients undergoing retroperitoneal lymph node dissection” (2020), 2020
  • American Association for the Advancement of Science (AAAS)/Science Program for Excellence in Science (2020), 2020
  • American Association for Cancer Research (AACR) Scholar-in-Training Award: “Comprehensive molecular and genomic characterization of pancreatic tropism in metastatic renal cell carcinoma” (2019), 2019
  • AVENIO Oncology Research Grant for ctDNA Competition (Roche): “Evaluating the prognostic utility of circulating tumor DNA profiling in metastatic and clinically localized clear cell renal cell carcinoma” (2019), 2019
  • American Urological Association (AUA) Early-Career Investigators Workshop Travel Award: “Evaluating the prognostic utility of circulating tumor DNA profiling in metastatic and clinically localized clear cell renal cell carcinoma” (2019), 2019
  • National Institutes of Health/National Cancer Institute (NIH/NCI) Ruth L. Kirschstein National Research Service Award (T32 Physician Scientist Oncology Training Program Research Grant) (2018-2019), 2018 - 2019
  • Rising Star in Oncology, Society for Translational Oncology Fellows’ Forum (STOFF) (2018), 2018
  • John Quale Travel Fellowship Award, Bladder Cancer Advocacy Network (BCAN) Bladder Cancer Think Tank (2018), 2018
  • Best Reviewer in 2017 Award, Elsevier (Journal of Urology), 2018
  • Winner, 6th Annual American Urological Association (AUA) National Chief Resident Debate (2018), 2018
  • Recognized Reviewer, Elsevier (Clinical Genitourinary Cancer (2015), Urologic Oncology (2018-2020), European Urology (2019), European Urology Oncology (2019), Urology Case Reports (2020)), 2015 - 2020
  • 1st Place, Resident Essay Competition. 95th Annual Meeting of South Central Section (SCS) American Urological Association (AUA) (2016)
  • Best poster in session, European Association of Urology (EAU) 31st Annual Congress. Munich, Germany (2016)
  • Full-Tuition Dean’s Merit Scholarship, University of Michigan Medical School (2009-2013), 2009 - 2013
  • Dean’s Award for Graduation with Distinction in (1) Research, (2) Medical Education, and (3) Service, University of Michigan Medical School (2013), 2013
  • Association for Academic Surgery (AAS) Student Research Award. “White matter hyperintensities and atrophy on MRI as a predictor of short term cognitive change following deep brain stimulation surgery in patients with Parkinson’s disease.” (2013), 2013

Memberships

  • American Urological Association (AUA)
  • Society of Urologic Oncology (SUO),Young Urologic Oncologists Section (YUO), SUO-Clinical Trials Consortium (CTC)
  • American Society of Clinical Oncology (ASCO)
  • American Association for Cancer Research (AACR)
  • Kidney Cancer Association (KCA)
  • American Association for the Advancement of Science (AAAS)
  • Société Internationale d’Urologie (SIU)
  • American Medical Association (AMA)
  • Indian American Urological Association (IAUA)
  • American Association of Clinical Urologists (AACU)
  • University of Michigan Department of Urology Reed Nesbit Society
  • International Young Urological Association (IYUA)
  • Association for Academic Surgery (AAS)

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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