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Ying S. Zou, M.D., Ph.D.

Photo of Dr. Ying S. Zou, M.D., Ph.D.
  • Associate Professor of Pathology

Background

Dr. Ying Zou is an Associate Professor of pathology at the Johns Hopkins University School of Medicine. Her areas of clinical expertise include the diagnosis of genetic abnormalities in patients with cancer or congenital diseases. Dr. Zou serves as Co-Director of the Cytogenetics and Cytogenomics laboratory at Johns Hopkins hospital, Director of the Cancer Cytogenetics laboratory, and Associate Director of Molecular Diagnostics laboratory. 

Dr. Zou is an expert in cytogenetics and clinical molecular genetics. She is interested in the development of clinical cytogenomic and molecular genetics laboratory tests that can be used in the clinical setting for better patient care, personalized medicine, as well as for discovering disease variants and novel cancer biomarkers. She has been involved in multiple clinical trials. Her research interests are centered on two main projects on the topic of (a) Understanding and interpretation of genomic data in human diseases and in cancer development and formation, and (b) Telomere biology in human aging and cancer. Dr. Zou has published more than 60 journal articles. 

As American Board of Medical Genetics and Genomics-certified in Clinical Cytogenetics and Clinical Molecular Genetics, Dr. Zou is active in the training of residents and fellows in several training programs, as well as students for clinical cytogenetics, molecular genetics, pharmaco-genomics and personalized medicine. She was recognized with The Best Attending Pathologist Teacher in Clinical Pathology by University of Maryland in 2017-2018.

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Titles

  • Associate Professor of Pathology

Departments / Divisions

Education

Degrees

  • Ph.D., University of Texas Southwestern Medical Center At Dallas, Southwestern Medical School (Texas) (2004)
  • M.D., Peking University (China) (1995)

Additional Training

  • Clinical Cytogenetics and Genomics by ABMGG, American Board of Medical Genetics and Genomics (2007)
  • Clinical Molecular Genetics by ABMGG, Amercian Board of Medical Genetics and Genomics (2009)

Research & Publications

Selected Publications

View all on Pubmed

Zou Y., Wright W., Shay J., Cornforth M (2004). Asynchronous replication timing of telomeres at opposite arms of mammalian chromosomes. Proc. Nat. Acad. Sci. (USA) 101:12928-12933

Zou Y., Sfeir A., Gryaznov S., Shay J., Wright W (2004). Does a sentinel or a subset of short telomeres determine replicative senescence? Mol. Biol. Cell. 15: 3709-3718

Zou Y., Misri S., Shay J., Pandita T., Wright W (2009). Altered states of telomere deprotection and the two-stage mechanism of replicative aging. Mol. Cell Biol. 29:2390-2397

Zou Y., Ouahchi K, Lu Y, Liu W, Christensen T, Schappert J, Saleki R (2012). Jumping translocations of 3q21 in an acute monocytic leukemia (M5) patient reveal mechanisms of multistage telomere shortening in pathogenesis of AML. Leukemia Res. 36:e31-33

Singh ZN, Richards S, El Chaer F, Duong VH, Gudipati MA, Waters EO, Koon S, Webley M, Pitel B, Hoppman NL, Baer MR, Zou YS (2019). Cryptic ETV6-PDGFRB fusion in a highly complex rearrangement of chromosomes 1, 5, and 12 due to a chromothripsis-like event in a myelodysplastic syndrome/myeloproliferative neoplasm. Leuk Lymphoma. 60(5): 1304-1307

Activities & Honors

Memberships

  • Fellow of American College of Medical Genetics and Genomics, 2007

    Fellow of American College of Medical Genetics and Genomics

  • Association for Molecular Pathology, 2009
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