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Amir Manbachi, M.Sc., Ph.D.

Photo of Dr. Amir Manbachi, M.Sc., Ph.D.
  • Assistant Professor of Neurosurgery

Background

Dr. Manbachi is an Assistant Professor of Neurosurgery and Biomedical Engineering at Johns Hopkins University. His research interests include applications of sound and ultrasound to various neurosurgical procedures. These applications include imaging the spine and brain, detection of foreign body objects, remote ablation of brain tumors, monitoring of blood flow and tissue perfusion, as well as other upcoming interesting applications such as neuromodulation and drug delivery. His teaching activities mentorship with BME Design Teams as well as close collaboration with clinical experts in Surgery and Radiology at Johns Hopkins. 

His previous work included the development of ultrasound-guided spine surgery. He obtained his PhD from the University of Toronto, under the supervision of Dr. Richard S.C. Cobbold. Prior to joining Johns Hopkins, he was a postdoctoral fellow at Harvard-MIT Division of Health Sciences and Technology (2015-16) and the founder and CEO of Spinesonics Medical (2012–2015), a spinoff from his doctoral studies.

Amir is an author on >25 peer-reviewed journal articles, > 30 conference proceedings, 10 invention disclosures / patent applications and a book entitled “Towards Ultrasound-guided Spinal Fusion Surgery.” He has mentored 150+ students, has so far been raised $1.1M of funding and his interdisciplinary research has been recognized by a number of awards, including University of Toronto’s 2015 Inventor of Year award, Ontario Brain Institute 2013 fellowship, Maryland Innovation Initiative and Cohen Translational Funding.

Dr. Manbachi has extensive teaching experience, particularly in the field of engineering design, medical imaging and entrepreneurship (both at Hopkins and Toronto), for which he received the University of Toronto’s Teaching Excellence award in 2014, as well as Johns Hopkins University career centre's award nomination for students' "Career Champion" (2018) and finally Johns Hopkins University Whiting School of Engineering's Robert B. Pond Sr. Excellence in Teaching Excellence Award (2018). 

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Titles

  • Assistant Professor of Neurosurgery
  • Assistant Professor of Biomedical Engineering

Departments / Divisions

Education

Degrees

  • Ph.D., University of Toronto (Canada) (2015)
  • M.Sc., University of Toronto (Canada) (2010)
  • B.Sc., University of Toronto (Canada) (2008)

Research & Publications

Research Summary

Personal Statement

My long-term goal is to initiate and lead meaningful research projects that can routinely generate clinical translation and commercial enterprises, hence benefiting medicine and society, and I currently do this through nurturing and mentoring the next generation of Biomedical Engineers (164 trainees to date) at Johns Hopkins while collaborating with Hopkins neurosurgeons on their ideas. What keeps me awake in the middle of the night is the anticipation of the next great scientific idea, and the next collaboration with clinicians, leading to a new generation of inventions, prototype developments, industrial partnerships, FDA approvals and market sales, thereby saving patients’ lives on a global caliber, in addition to creating jobs, thereby helping the local community. Biomedical engineers are poised to make unparalleled impact and save lives by inventing devices that can help millions of patients worldwide, and I am committed to fulfilling that role! My interests and expertise are in the following areas: physics of acoustics, as well as design and fabrication of novel image-guided interventions (primarily ultrasound imaging, and most recently therapeutic ultrasound), with a passion for clinical translation and quality assurance for patient safety. My clinical research interests and involvement since my Ph.D. have been primarily on minimally invasive approaches in the areas of neurosurgery, specifically in brain and spine. Having founded a company based on my Ph.D. studies (Spinesonics Medical Inc.), currently leading another entrepreneurial initiative to develop a focused ultrasound device (for which we have already raised over $250K), and closely mentoring close to 40 design projects in affiliation with the Center for Bioengineering Innovation and Design (CBID) and the JHU BME undergraduate design program, our department's remarkable record for clinically driven research and innovation deeply resonate with me. In particular, this department offers exceptional access to medical and engineering resources, and I have fully leveraged that in my collaborations with the Departments of Surgery and Radiology, and the Armstrong Institute for Patient Safety.

Mission Statement

(1) To bring novel medical devices into the neurosurgical world by exploring innovative designs; (2) scholarship through communicating the findings to the world; and (3) training the next generation of biomedical engineers, passionate about changing the paradigm of brain and spinal cord injury treatments.

Lab

At Manbachi lab, we engineer, design and fabricate non-invasive and minimally invasive devices for neuro applications. 

With a focus on acoustic probes and ultrasound transducers, the range of applications for these probes vary from imaging and image-guided interventions, to therapeutics (oncology ablations), Drug Delivery, Piezo-electric cutters, Thermometry, cell-localization and Neuromodulation.

Technology Expertise Keywords

Medical Device Design; Ultrasound; Neurosurgery; Spine

Selected Publications

View all on Pubmed

Bechtold R, Tselepidakis N, Garlow B, Glaister S, Zhu W, Liu R, Szwec A, Tandon A, Buono Z, Pitingolo J, Madalo C, Ferrara I, Shale C, Benassi T, Belzberg M, Gorelick N, Hwang B, Coles G, Tyler B, Suk I, Huang J, Brem H, and Manbachi A "Minimizing cotton retention in neurosurgical procedures: which imaging modality can help?", Proc. SPIE, Medical Imaging 2020: Biomedical Applications in Molecular, Structural, and Functional Imaging, 1131704; https://doi.org/10.1117/12.2548847

Manbachi A, Kambhampati S, Ainechi A, Mahapatra S, Belzberg M, Ying G, Chai R, Zhang YS, Gorelick N, Pennington Z, Westbroek E, Jiang B, Hwang B, Benassi T, Coles G, Tyler B, Suk I, Yazdi Y, and Theodore N "Intraoperative ultrasound to monitor spinal cord blood flow after spinal cord injury", Proc. SPIE, Medical Imaging 2020: Biomedical Applications in Molecular, Structural, and Functional Imaging, 113170B; https://doi.org/10.1117/12.2548789

Manbachi A, Logsdon EA, Yazdi Y, and Durr NJ. "Curricular Advancement of Biomedical Engineering Undergraduate Design Projects Beyond 1 Year: A Pilot Study." Ann Biomed Eng (2019). https://doi.org/10.1007/s10439-019-02434-7

Belzberg M, Chavez F, Xiong KT, Morrison K, Gamo NJ, Restaino S, Iyer R, Groves M, Thakor N, Brem H, Cohen AR, and Manbachi A "Minimally invasive intraventricular ultrasound: design and instrumentation towards a miniaturized ultrasound-guided focused ultrasound probe", Proc. SPIE, Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling, 109512Y; https://doi.org/10.1117/12.2513150

Manbachi A, Kreamer-Tonin K, Walch P, Khoshakhlagh P, Zhang YS, Montague C, Acharya S, Logsdon EA, Allen RA, Durr NJ, Luciano MG, Theodore N, Brem H, Yazdi Y "Starting A Medical Technology Venture as an Young Academic Innovator or Student Entrepreneur" Ann Biomed Eng (2018) 46: 1. https://doi.org/10.1007/s10439-017-1938-x

Patents

Flexible control and guidance of minimally invasive focused ultrasound
Patent # WO2018160657A1 | 02/28/2017

An embodiment in accordance with the present invention provides a transducer design for minimally invasive focused ultrasound (MIFU). The present invention allows flexible control of a focused ultrasound wave using mechanical and electrical control. The transducer array is implemented on a flexible substrate that can be mechanically controlled through two or more physical configurations. As with conventional electronic "steering," the transducer elements can be controlled electronically to provide adjustable focus of the ultrasound. The combination of mechanical and electronic control provides the device a very flexible method for delivering focused ultrasound. The invention also includes a design that allows integration of ultrasound and endoscopic image guidance. The ultrasound guidance includes anatomical visualization and functional imaging (e.g. blood flow and coagulation of vasculature). The ultrasound imaging transducer is used for thermometry within the region of interest for treatment. Endoscopic imaging allows for improved understanding of tip location in real-time.

Ultrasonic signal processing for bone sonography
Patent # WO2014186903A1 | 05/24/2013

This invention relates to methods and devices for use in ultrasound imaging. Ultrasonic methods, systems and low-frequency annular transducer array devices for bone image guidance, particularly during spinal fusion surgery and the process of pedicle screw insertion are provided.

Ultrasonic array for bone sonography
Patent # WO2014186903A1 | 04/25/2013

This invention relates to methods and devices for use in ultrasound imaging. Ultrasonic methods, systems and low-frequency annular transducer array devices for bone image guidance, particularly during spinal fusion surgery and the process of pedicle screw insertion are provided.

Academic Affiliations & Courses

Graduate Program Affiliation

Affiliate Faculty, Center for Bioengineering Innovation and Design

Affiliate Faculty, Armstrong Institute for Patient Safety and Quality

Courses and Syllabi

  • BME Design Group (EN.580.411)
  • Advanced Design Team: Instrumentation (EN.580.498)
  • Senior Design Project (EN.580.580 / 581)
  • Biomedical Engineering Undergraduate Research (EN.580.511)

Activities & Honors

Honors

  • Robert B. Pond Sr. Excellence in Teaching Excellence Award, Johns Hopkins University, Whiting School of Engineering, 2018 - 2018
  • University of Toronto's Inventor of the year award, University of Toronto, 2015 - 2015
  • Ontario Brain Institute 2013 Entrepreneurial fellowship, Ontario Brain Institute, 2013 - 2014

Memberships

  • Biomedical Engineering Society
  • BME-IDEA: Biomedical Engineering Innovation, Design and Entrepreneurship Alliance

    The Biomedical Engineering Innovation, Design and Entrepreneurship Alliance (BME-IDEA) is a ?consortium of leading faculty? at over 150 ?institutions who are committed to sharing best practices in teaching innovation, design, technology transfer, and entrepreneurship.

  • Design of Medical Devices
  • SPIE Medical Imaging

Videos & Media

Recent News Articles and Media Coverage

Hopkins-born venture aims to use ultrasound technology to treat brain tumors, Baltimore Business Journal (Jan 2018)

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