- Associate Professor of Medicine
- Associate Professor of Biological Chemistry
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Regulatory role of microRNAs and RNA-binding proteins in energy metabolism; Mechanisms of metabolic disease; Diabetes and obesity ...read more
Adaptation to environmental stress is a fundamental cellular process that promotes the maintenance of the physiologic steady state. Stress responses have been shown to induce numerous changes, such as activation of gene expression programs which have evolved to allow for the cell to promote its own survival. The focus of my laboratory is to elucidate the molecular mechanisms which impact energy homeostasis and contribute to the pathogenesis of metabolic diseases including diabetes. Many insights into the functional role of microRNAs have recently been made, improving our understanding of how these small RNAs integrate into the complex landscape of gene expression. In addition, the profiling of non-coding RNAs from numerous disease states such as cancer, hyperglycemia, obesity and insulin resistance, and inflammation has identified dramatic changes in many abundant small RNA sequences indicating RNA silencing plays a significant role in adapting cells to changes in their metabolic environment. Our current research goals are to identify and characterize the RNA silencing mechanisms which regulate energy homeostasis during changes in nutrient availability and how this pathway ultimately contributes to the metabolic disease including diabetes and obesity.
Yan X, Wang Z, Bishop CA, Weitkunat K, Feng X, Tarbier M, Luo J, Friedlander MR, Burkhardt R, Klaus S, Willnow TE, Poy MN. Control of hepatic gluconeogenesis by Argonaute2. Mol Metab. 2018 Oct 9. pii: S2212-8778(18)30794-4. doi: 10.1016/j.molmet.2018.10.003.
Yan X, Wang Z, Schmidt V, Gauert A, Willnow TE, Heinig M, Poy MN. Cadm2 regulates body weight and energy homeostasis in mice. Mol Metab. 2018 Feb;8:180-188. doi: 10.1016/j.molmet.2017.11.010. Epub 2017 Nov 22. PMID: 29217450
Yan X, Wang Z, Westberg-Rasmussen S, Tarbier M, Rathjen T, Tattikota SG, Peck BCE, Kanke M, Oxvig C, Frystyk J, Starup-Linde J, Sethupathy P, Friedlander MR, Gregersen S, Poy MN.Differential Impact of Glucose Administered Intravenously and Orally on Circulating miR-375 Levels in Human Subjects. J Clin Endocrinol Metab. 2017 Oct 1;102(10):3749-3755. doi: 10.1210/jc.2017-01365. PMID: 28973164
Rathjen T, Yan X, Kononenko NL, Ku MC, Song K, Ferrarese L, Tarallo V, Puchkov D, Kochlamazashvili G, Brachs S, Varela L, Szigeti-Buck K, Yi CX, Schriever SC, Tattikota SG, Carlo AS, Moroni M, Siemens J, Heuser A, van der Weyden L, Birkenfeld AL, Niendorf T, Poulet JFA, Horvath TL, Tschop MH, Heinig M, Trajkovski M, Haucke V, Poy MN. Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1. Nat Neurosci. 2017 Aug;20(8):1096-1103. doi: 10.1038/nn.4590. Epub 2017 Jun 19. PMID: 28628102
Tattikota SG, Rathjen T, McAnulty SJ, Wessels HH, Akerman I, van de Bunt M, Hausser J, Esguerra JL, Musahl A, Pandey AK, You X, Chen W, Herrera PL, Johnson PR, O'Carroll D, Eliasson L, Zavolan M, Gloyn AL, Ferrer J, Shalom-Feuerstein R, Aberdam D, Poy MN. Argonaute2 mediates compensatory expansion of the pancreatic β cell. Cell Metab. 2014 Jan 7;19(1):122-34. doi: 10.1016/j.cmet.2013.11.015. Epub 2013 Dec 19. PMID: 24361012