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Kristen Ashley Marrone, M.D.

Photo of Dr. Kristen Ashley Marrone, M.D.
  • Associate Program Director, Hematology/Medical Oncology Fellowship Program
  • Assistant Professor of Oncology



Research Interests

Non-small Cell Lung Cancer (NSCLC); Oncogene Mutated NSCLC; Immunotherapy; Tumor Metabolism

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Skip Viragh Outpatient Cancer Center

Appointment Phone: 410-955-8964
201 N. Broadway
Baltimore, MD 21287 map
Phone: 410-955-7458 | Fax: 410-550-4525

Johns Hopkins Bayview Medical Center

300 Mason Lord Drive
Sidney Kimmel Comprehensive Cancer Center
Baltimore, MD 21224 map
Phone: 410-550-1711


Dr. Kristen Marrone is a thoracic medical oncology specialist in Baltimore, caring for patients with lung cancer and esophageal cancer. She serves as the Associate Program Director of the Hematology/Medical Oncology Fellowship Program at the Johns Hopkins School of Medicine.

Dr. Marrone received her undergraduate degree in psychology with a neuroscience concentration from Pennsylvania State University. She earned her M.D. from Drexel University College of Medicine. She completed her residency at Yale-New Haven Hospital and performed a fellowship in hematology and oncology at Johns Hopkins University School of Medicine. Dr. Marrone joined the Johns Hopkins faculty in 2017.

Her research interests include non-small cell lung cancer, with a focus on clinical trial development focusing on optimization of immunotherapy in oncogene driven non-small cell lung cancer. 

Dr. Marrone is a member of the American Association of Cancer Research, the American Society of Clinical Oncology, the International Association for Study of Lung Cancer and the Society for Immunotherapy in Cancer. more


  • Associate Program Director, Hematology/Medical Oncology Fellowship Program
  • Assistant Professor of Oncology

Departments / Divisions

Centers & Institutes



  • MD, Drexel University College of Medicine (2011)


  • Yale-New Haven Hospital / Internal Medicine (2014)


  • Johns Hopkins University School of Medicine / Hematology and Oncology (2017)

Board Certifications

  • American Board of Internal Medicine / Internal Medicine (2014)
  • American Board of Internal Medicine / Medical Oncology (2017)

Research & Publications

Research Summary

Non-small cell lung cancer (NSCLC); oncogene mutated NSCLC; immunotherapy; tumor metabolism

Clinical Trial Keywords

Non-Small Cell Lung Cancer (NSCLC), epidermal derived growth factor receptor (EGFR), KRAS

Selected Publications

Cortazar FB, Kibbelaar ZA, Glezerman IG, Abudayyeh A, Mamlouk O, Motwani SS, Murakami N, Herrmann SM, Manohar S, Shirali AC, Kitchlu A, Shirazian S, Assal A, Vijayan A, Renaghan AD, Ortiz-Melo DI, Rangarajan S, Malik AB, Hogan JJ, Dinh AR, Shin DS, Marrone KA, Mithani Z, Johnson DB, Hosseini A, Uprety D, Sharma S, Gupta S, Reynolds KL, Sise ME, Leaf DE. "Clinical Features and Outcomes of Immune Checkpoint Inhibitor-Associated AKI: A Multicenter Study." J Am Soc Nephrol. 2020 Feb;31(2):435-446

Zhang J, Ji Z, Caushi JX, El Asmar M, Anagnostou V, Cottrell TR, Chan HY, Suri P, Guo H, Merghoub T, Chaft JE, Reuss JE, Tam AJ, Blosser RL, Abu-Akeel M, Sidhom JW, Zhao N, Ha JS, Jones DR, Marrone KA, Naidoo J, Gabrielson E, Taube JM, Velculescu VE, Brahmer JR, Housseau F, Hellmann MD, Forde PM, Pardoll DM, Ji H, Smith KN. "Compartmental Analysis of T-cell Clonal Dynamics as a Function of Pathologic Response to Neoadjuvant PD-1 Blockade in Resectable Non-Small Cell Lung Cancer." Clin Cancer Res. 2019 Nov 21

Topper MJ, Vaz M, Marrone KA, Brahmer JR, Baylin SB. "The emerging role of epigenetic therapeutics in immuno-oncology." Nat Rev Clin Oncol. 2020 Feb;17(2):75-90

Balaji A, Zhang J, Wills B, Marrone KA, Elmariah H, Yarchoan M, Zimmerman JW, Hajjir K, Venkatraman D, Armstrong DK, Laheru DA, Mehra R, Ho WJ, Reuss JE, Heng J, Vellanki P, Donehower RC, Holdhoff M, Naidoo J. "Immune-Related Adverse Events Requiring Hospitalization: Spectrum of Toxicity, Treatment, and Outcomes." J Oncol Pract. 2019 Sep;15(9):e825-e834

Suresh K, Naidoo J, Zhong Q, Xiong Y, Mammen J, de Flores MV, Cappelli L, Balaji A, Palmer T, Forde PM, Anagnostou V, Ettinger DS, Marrone KA, Kelly RJ, Hann CL, Levy B, Feliciano JL, Lin CT, Feller-Kopman D, Lerner AD, Lee H, Shafiq M, Yarmus L, Lipson EJ, Soloski M, Brahmer JR, Danoff SK, D'Alessio F. "The alveolar immune cell landscape is dysregulated in checkpoint inhibitor pneumonitis." J Clin Invest. 2019 Jul 16;130:4305-4315. Parikh AB, Marrone KA, Becker DJ, Brahmer JR, Ettinger DS, Levy BP. "A pooled analysis of two phase II trials evaluating metformin plus platinum-based chemotherapy in advanced non-small cell lung cancer." Cancer Treat Res Commun. 2019 May 10;20: 100150

Academic Affiliations & Courses

Graduate Program Affiliation

OncologyUpper Aerodigestive Cancer

Courses and Syllabi

  • Mock Tumor Board
    Faculty Lecturer
  • Epidemiology, Staging and Molecular Diagnosis in Cancer
  • Genes to Society Pulmonary Course, Student Presentations
    Faculty Mentor
  • Summer Lecture Series—Lung Cancer Case Review
  • Oncologic Emergencies
  • Genes to Society Oncology Course
    Small Group Co-leader

Activities & Honors


  • Gold Humanism Honor Society, 2013
  • Alpha Omega Alpha, Member, 2011


  • American Association of Cancer Research
  • American Society of Clinical Oncology (ASCO)
  • International Association for the Study of Lung Cancer (IASLC)
  • Society for Immunotherapy in Cancer

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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