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Emmanouil Tampakakis, M.D.

Photo of Dr. Emmanouil Tampakakis, M.D.
  • Assistant Professor of Medicine

Languages: English, Greek


Cardiac Amyloidosis, General Cardiology, Inherited Cardiomyopathies, Internal Medicine


Johns Hopkins Outpatient Center

601 N. Caroline St.
Baltimore, MD 21287 map

The Johns Hopkins Hospital (Main Entrance)

1800 Orleans St.
Baltimore, MD 21287 map


Dr. Emmanouil Tampakakis is an instructor in the Department of Medicine at Johns Hopkins University School of Medicine as well as an attending physician at Johns Hopkins Hospital.

His research at the Chulan Kwon’s Laboratory of Heart Development and Stem Cell Biology focuses on understanding the biology and regenerative potential of cardiac progenitor cells, using human induced pluripotent stem cells for modeling cardiomyopathies and deciphering the mechanisms of cardiac maturation. Dr. Tampakakis also holds a cardiology fellowship at Johns Hopkins Hospital.

Dr. Tampakakis received his undergraduate degree and M.D. from the University of Crete. He completed an internal medicine residency at Boston University Medical Center. 

Prior to joining Johns Hopkins in 2012, Dr. Tampakakis was a research fellow in Dr. J. Vita’s laboratory of Vascular Biology at Boston University School of Medicine.

Dr. Tampakakis is the recipient of the Mid Atlantic Capital Cardiology Symposium, Young Investigator Award and was most recently honored with an AHA Scientific Sessions Travel Award and has been a Northwestern Young Investigator Forum Finalist. more


  • Assistant Professor of Medicine

Departments / Divisions



  • MD, University of Crete Faculty of Medicine (2005)


  • Boston Medical Center / Internal Medicine (2011)


  • Johns Hopkins University School of Medicine / Cardiology (2016)

Board Certifications

  • American Board of Internal Medicine / Cardiovascular Disease (2015)
  • American Board of Internal Medicine / Internal Medicine (2011)

Research & Publications

Research Summary

Research Fellow in Dr. C. Kwon’s Laboratory of Developmental and Stem Cell Biology.

Heart malformation is the most frequent form of human birth defects, and cardiovascular disease remains the leading cause of death worldwide. The limited regenerative capacity of the heart is a major factor in the morbidity and mortality rates. Cardiovascular progenitor cells hold tremendous therapeutic potential due to their unique ability to expand and differentiate into various heart cell types.

The C. Kwon laboratory focuses on understanding the biology and regenerative potential of multi-potent cardiac progenitor cells by deciphering the molecular and cellular mechanisms that control their induction, maintenance and differentiation. We are also investigating how cardiac muscles undergo maturation. We developed several novel approaches to deconstruct the mechanisms, including the use of animal models and pluripotent stem cell systems. We expect this knowledge will help us better understand heart disease and will be instrumental for stem-cell-based disease modeling and interventions for of heart repair.

Activities & Honors


  • NIH-NHLBI, K08 Mentored Clinical Scientist Research Career Development Award
  • AHA Career Development Award, 2019
  • ACC Presidential Career Development Award, 2019
  • Weinstein Heart Development and Regeneration Conference Travel Award, 2018
  • The Magic That Matters Fund, Johns Hopkins School of Medicine, 2018
  • Northwestern Young Investigator Forum Finalist, 2016
  • AHA Scientific Sessions Travel Award, 2016
  • Clinician Scientist Award, Johns Hopkins University, 2016
  • Mid Atlantic Capital Cardiology Symposium, Young Investigator Award Winner, 2015 - 2016


  • Member, American College of Cardiology, 2012
  • Member, American Heart Association, 2010
  • Member, American Medical Association, 2010
  • Member, American College of Physicians, 2009

Videos & Media

Recent News Articles and Media Coverage

Hopkins researchers discover newborn rats hold secret to manufacturing human heart cells., The Baltimore Sun, (February 11, 2017). 

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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