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School of Medicine
Aaron Watkins James, M.D., Ph.D.
Associate Professor of Pathology
Expertise: Orthopaedic Pathology, Pathology
Research Interests: Bone biology; Osteogenesis; Skeletal repair; Mesenchymal stem cells; Osteosarcoma
Dr. James received his M.D. with thesis from the University of California, San Francisco with research at Stanford University. Dr. James performed his residency in Anatomic Pathology and fellowships in Orthopaedic Pathology and Surgical Pathology at the University of California, Los Angeles. He received his Ph.D. in bone biology and osteoprogenitor cells from University of California, Los Angeles.
Dr. James is a dual physician-scientist and bone tissue pathologist, with research interests in bone tissue regeneration and repair. Current research interests include perivascular mesenchymal progenitor cells for bone tissue engineering, and novel growth and differentiation factors to speed bone repair. Other interests include an examination of the supporting tissues for osteogenesis and bone repair, including the peripheral nervous system, as well as the study of bone-forming tumors (osteosarcoma) and the development of novel therapies. His work requires the intersection and collaboration of multiple disciplines, including collaborations within Pathology, Orthopaedic Surgery, Plastic and Reconstructive Surgery, Dental Sciences, Engineering, Bioengineering, and Material Sciences.
- Associate Professor of Pathology
- MD, University of California San Francisco (2010)
- UCLA Medical Center David Geffen School of Medicine / Anatomic Pathology (2015)
- UCLA Medical Center David Geffen School of Medicine (2016)
- American Board of Pathology / Anatomic Pathology (2015)
Research & Publications
Lab Website: James Laboratory
Selected PublicationsView all on Pubmed
James AW, Zara JN, Zhang X, Askarinam A, Goyal R, Chiang M, Yuan W, Chang L, Corselli M, Shen J, Pang S, Stoker D, Ting K, Peault B, Soo C. Perivascular stem cells: a prospectively purified mesenchymal stem cell population for bone tissue engineering. Stem Cells Transl Med, Jun 2012; 1(6): 510-9. PMCID: PMC3659717
James AW, Zara JN, Corselli M, Askarinam A, Zhou AM, Hourfar A, Nguyen A, Megerdichian S, Asatrian G, Pang S, Stoker D, Zhang X, Wu B, Ting K, Peault B, Soo C. An abundant perivascular source of stem cells for bone tissue engineering. Stem Cells Transl Med, Sep 2012; 1(9): 673-84. PMCID: PMC3659737
Shen J, Shrestha S, Yen YH, Scott MA, Soo C, Ting K, Dry SM, Peault B, James AW. The pericyte antigen RGS5 in perivascular soft tissue tumors. Hum Path. Jan 2016; 47(1): 121-31. PMCID: PMC4861638. Corresponding author
Shen J, Shrestha S, Rao PN, Asatrian G, Scott MA, Nguyen V, Giacomelli P, Soo C, Ting K, Eilber FC, Peault B, Dry SM, James AW. Pericytic mimicry in well-differentiated liposarcoma / atypical lipomatous tumor. Hum Pathol, Apr 2016; Epub ahead of print. Corresponding author
James AW, Shen J, Zhang X, Asatrian G, Goyal R, Kwak JH, Bengs B, Culiat CT, Turner S, Seim HB, Lyons K, Adams JS, Ting K, Soo C. NELL-1 in the Treatment of Osteoporotic Bone Loss. Nature Communications, Jun 2015; 6:7362. PMCID: PMC4557288
Activities & Honors
- Excellence in Research Award for a Resident. Carre AL, James AW, Kawai K, MacLeod L, Longaker MT, Lorenz HP. High expression of collagen XV and non-fibrillar elastic fibers in embryonic as compared to postnatal skin. American College of Surgeons 2009 Clinical Congress, October 2009.
- Excellence in Research Award in Orthopaedics, James AW, Nguyen VT, Zara JN, Chiang M, Soofer D, Zhang X, Ting K, Soo C. Nell-1 deficiency results in an osteopenic / osteoporotic phenotype. American College of Surgeons, Oct 2011, San Francisco, California.
- Best Paper of the Year: Levi B, James AW, Nelson ER, Peng M, Joubert LM, Vistnes D, Wu J, Longaker MT. Studies in adipose-derived stromal cells: Migration and participation in repair of cranial injury after systemic injection. Plastic and Reconstructive Surgery, Mar 2011, 127(3):1130-40. American Society of Maxillofacial Surgery, 2011
- President’s Poster Competition Winner, James AW, Shen J, Zhang X, Kim TM, Le K, Nguyen A, Rackohn T, Soofer D, Culiat CT, Adams JS, Ting K, Soo C. A new protective function of Nell-1 against osteoporosis by activation of Wnt/Beta-catenin signaling, ASBMR, Oct 2012, Minneapolis, MN.
- Spotlight Podium Presentation, James AW, Askarinam A, Pan A, Chang L, Goyal R, Rackohn T, Le K, Chung C, Zara JN, Corselli M, Zhang X, Stoker D, Ting K, Peault B, Soo C. Purified perivasc
- Best Abstract Award, International Society of Bone and Soft Tissue Pathology. James AW, Chung C, Asatrian G, Velasco O, Pan A, Nguyen A, Liang P, Stoker D, Ting K, Peault B, Soo C. Perivascular stem cells induce bone formation and vasculogenesis in ectopic and bone injury models. 102nd USCAP, Baltimore, MD, Mar 2013.
- Lead Guest Editor, Advances in Bone Tissue Engineering and Regeneration, Special Issue of BioMed Research International, Mar 2013.
- Young Investigator’s Award, ASBMR. James AW, Shen J, Velasco O, Asatrian G, Chung CG, Khadarian K, Zhang Y, Chang L, Goyal R, Kim J, Zhang X, Adams JS, Ting K, Soo C. Systemic administration of NELL-1, a Wnt/Beta catenin regulator, induces bone formation in osteoporotic mice via Integrin beta1. ASBMR 2013, Oct 2013, John H Carstens Distinguished Oral Presentation.
- International Investigator’s Award, JSBMR / BRS. James AW, Shen J, Velasco O, Asatrian G, Chung CG, Khadarian K, Zhang Y, Chang L, Goyal R, Kim J, Zhang X, Adams JS, Ting K, Soo C. Systemic administration of NELL-1, a Wnt/Beta catenin regulator, induces bone formation in osteoporotic mice via Integrin beta1. ASBMR 2013, Oct 2013.
- Best Pediatrics/Developmental Biology Abstract. Asatrian G, James AW, Zhang Y, Chung CG, Velasco O, Zhang X, Ting K, Soo C. Systemic delivery of chemically modified NELL-1 promotes bone formation in osteoporotic mice. 9th Annual Academic Surgical Congress, Feb 2013.
- Review Editorial Board Member, Stem Cell Treatments, Frontiers in Cell and Developmental Biology and Bioengineering and Biotechnology, starting Dec 2013.
- Editorial Board Member, International Journal of Orthopaedics, starting Apr 2014.
- Daljit S. and Elaine Sarkaria Fellowship Award, Department of Pathology and Laboratory Medicine, UCLA, Sep 2014.
- Associate Editor and Editorial Board Member, Journal of Stem Cell Research & Therapeutics, starting Jun 2015.
- James AW, Shen J, Asatrian G, Shrestha S, Wu B, Zhang X, Ting K, Soo C. NELL-1 induces expansion of Sca-1+ mesenchymal stem cell population for bone formation from small to large animal models. The American Society for Bone and Mineral Research (ASBMR), Sep 2015, Oral Poster Presentation, Plenary Poster Presentation, Young Investigator Travel Award.
- Member, Young Investigator Subcommittee. The American Society for Bone and Mineral Research (ASBMR). Sep 2015.
- United States and Canadian Academy of Pathology, Member, 2012
- International Society of Bone and Soft Tissue Pathology, Member, 2013
- American Society of Bone and Mineral Research, Member, 2013