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Anthony K.L. Leung, Ph.D.

Photo of Dr. Anthony K.L. Leung, Ph.D.
  • Joint Appointment in Molecular Biology and Genetics
Male

Research Interests

non-coding RNAs; RNA-binding proteins; post-translational modifications; PARP inhibitors; RNA granules; diagnostics; proteomics

Background

Titles

  • Joint Appointment in Molecular Biology and Genetics
  • Joint Appointment in Oncology

Departments / Divisions

Centers & Institutes

Education

Degrees

  • Ph.D., University of Dundee (United Kingdom) (2003)

Research & Publications

Lab

Laboratory of Gene Regulation

My research program focuses on how gene regulation impacts diseases states including cancer, neurodegeneration and virus infection. Recent research focus includes noncoding RNAs, such as circular RNAs and microRNAs, and a druggable protein modification called poly(ADP-ribose). Poly(ADP-ribose) polymerase (PARP) inhibitors are currently approved by FDA to treat multiple cancers. Though therapeutically important, this modification is understudied partly due to a woeful lack of tools. My team invents  tools to investigate this protein modification, discovering its roles in various RNA processes, RNA virus infection, and the formation of membrane-less organelles. To dissect the underlying mechanisms, our team also use a range of multi-disciplinary techniques from chemical probe synthesis, single-molecule biophysical measurements and quantitative imaging to informatics, genomics and proteomics approaches. Our team is highly collaborative drawing expertise within the lab, the university and around the world. Our goal is to translate our multi-dimensional scientific findings to therapy and diagnostics.

Selected Publications

View all on Pubmed

McPherson RL, Abraham R, Sreekumar E, Ong SE, Cheng SJ, Baxter VK, Kistemaker HA, Filippov DV, Griffin DE, Leung AK. ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence. PNAS 2017; 114(7):1666-1671.

Vivelo CA, Wat R, Agrawal C, Tee HY, Leung AK. ADPriboDB: The database of ADP-ribosylated proteins. Nucleic acids research. 2017; 45(D1):D204-D209.

Daniels CM, Ong SE, Leung AK. Phosphoproteomic approach to characterize protein mono- and poly(ADP-ribosyl)ation sites from cells. Journal of proteome research. 2014; 13(8):3510-22.

Leung AK, Vyas S, Rood JE, Bhutkar A, Sharp PA, Chang P. Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm. Molecular Cell. 2011; 42(4):489-99.

Ando Y, Elkayam E, McPherson RL, Dasovich M, Cheng SJ, Voorneveld J, Filippov DV, Ong SE, Joshua-Tor L, Leung AK (2019). ELTA: Enzymatic Labeling of Terminal ADP-ribose. Mol Cell 73:845-856.e5

Academic Affiliations & Courses

Graduate Program Affiliation

Biochemistry and Molecular Biology (JHSPH)

Biochemistry, Cellular and Molecular Biology (JHSOM)

Human Genetics Program, Institute of Genetic Medicine (JHSOM)

Chemistry–Biology Interface (JHU)

Activities & Honors

Honors

  • Idea Award, Department of Defense Breast Cancer Research Program
  • Faculty Innovation Award, Johns Hopkins Bloomberg School of Public Health
  • Johns Hopkins Catalyst Award
  • American Cancer Society Research Scholar Award
  • Johns Hopkins Discovery Award
  • W. W. Smith Charitable Trust Medical Research Award
  • Teaching Excellence Award, Johns Hopkins Bloomberg School of Public Health
  • Shikani/El-Hibri Prize for Discovery & Innovation, Johns Hopkins Bloomberg School of Public Health
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