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Anthony K.L. Leung, Ph.D.

Photo of Dr. Anthony K.L. Leung, Ph.D.

Joint Appointment in Molecular Biology and Genetics

Research Interests: non-coding RNAs; RNA-binding proteins; post-translational modifications; PARP inhibitors; RNA granules; diagnostics; proteomics

Background

Titles

  • Joint Appointment in Molecular Biology and Genetics
  • Joint Appointment in Oncology

Education

Degrees

  • Ph.D., University of Dundee (United Kingdom) (2003)

Research & Publications

Lab

Laboratory of Gene Regulation

Gene regulation: Using multi-disciplinary and quantitative imaging, genomics and proteomics approaches, my lab uncovers novel roles of non-coding RNAs, non-membranous granules, and post-translational modifications.

Technology development: My lab develops proteomics and informatics tools to dissect the roles of a post-translational modification called ADP-ribosylation. 

Disease focus: My lab seeks to translate our basic science findings to therapy, e.g., PARP inhibitor in cancers and Chikungunya viral infection.

Selected Publications

View all on Pubmed

McPherson RL, Abraham R, Sreekumar E, Ong SE, Cheng SJ, Baxter VK, Kistemaker HA, Filippov DV, Griffin DE, Leung AK. ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence. PNAS 2017; 114(7):1666-1671.

Vivelo CA, Wat R, Agrawal C, Tee HY, Leung AK. ADPriboDB: The database of ADP-ribosylated proteins. Nucleic acids research. 2017; 45(D1):D204-D209.

Daniels CM, Ong SE, Leung AK. The Promise of Proteomics for the Study of ADP-Ribosylation. Molecular Cell. 2015; 58(6):911-24.

Daniels CM, Ong SE, Leung AK. Phosphoproteomic approach to characterize protein mono- and poly(ADP-ribosyl)ation sites from cells. Journal of proteome research. 2014; 13(8):3510-22.

Leung AK, Vyas S, Rood JE, Bhutkar A, Sharp PA, Chang P. Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm. Molecular Cell. 2011; 42(4):489-99.

Academic Affiliations & Courses

Graduate Program Affiliation

Biochemistry and Molecular Biology (JHSPH)

Biochemistry, Cellular and Molecular Biology (JHSOM)

Human Genetics Program, Institute of Genetic Medicine (JHSOM)

Chemistry–Biology Interface (JHU)

Activities & Honors

Honors

  • Idea Award, Department of Defense Breast Cancer Research Program
  • Faculty Innovation Award, Johns Hopkins Bloomberg School of Public Health
  • Johns Hopkins Catalyst Award
  • American Cancer Society Research Scholar Award
  • Johns Hopkins Discovery Award
  • W. W. Smith Charitable Trust Medical Research Award
  • Teaching Excellence Award, Johns Hopkins Bloomberg School of Public Health
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