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Chuan-Hsiang Huang, M.D., Ph.D.

Photo of Dr. Chuan-Hsiang Huang, M.D., Ph.D.

Assistant Professor of Pathology

Background

Chuan-Hsiang (Bear) Huang, M.D., Ph.D., joined our faculty in Gynecologic Pathology in July 2016. Dr. Huang received his M.D. from National Taiwan University and completed two years of residency in internal medicine before joining the Graduate Program in Immunology here at Johns Hopkins.  His Ph.D. work, conducted in the labs of Mario Amzel and Bert Vogelstein, focused on structural studies of PI3Ka, one of the most frequently mutated proteins in human cancers and an important drug target. Using X-ray diffraction methods, Dr. Huang determined the first crystal structure of the PI3Ka heterodimer, elucidating the basis of PI3K over-activation in cancers.  To further understand the cellular biology of PI3K signaling, Dr. Huang conducted his postdoctoral research in the Devreotes lab on cell motility using Dictyostelium and human neutrophils as models. Combining single cell imaging with quantitative modeling, Dr. Huang revealed the dynamic properties of the Ras-PI3K signaling network and how it couples to the cytoskeleton during cell migration and chemotaxis. In his ongoing research, Dr. Huang is investigating the dynamics, regulation, and functions of the signaling network involving Ras, PI3K, and ERK in cellular processes and disease pathogenesis.

Dr. Huang has numerous publications, including papers in Science, Nature Cell Biology, and Nature Communications. He has received numerous awards, including the Silver Medal in the 33rd International Mathematical Olympiad, the Mette Strand Award, the Julian Baumert Thesis Award, and the Damon Runyon Fellowship.

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Titles

  • Assistant Professor of Pathology

Departments / Divisions

Education

Degrees

  • M.D., National Taiwan University (Taiwan) (1999)
  • Ph.D., Johns Hopkins University School of Medicine (Maryland) (2009)

Research & Publications

Lab Website: Huang Laboratory

Selected Publications

View all on Pubmed

Yang JM, Bhattacharya S, West-Foyle H, Hung CF, Wu TC, Iglesias PA, Huang CH. Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation. Nat Commun. 2018; 9(1), 4673.

Tang M, Wang M, Shi C, Iglesias PA and Devreotes PN, Huang CH. "Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis." Nat Commun. 2014; 5: 5175

Huang CH, Tang M, Shi C, Iglesias PA, Devreotes PN. "An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration." Nat Cell Biol. 2013; 15(11): 1307-1316

Huang CH, Mandelker D, Schmidt-Kittler O, Samuels Y, Velculescu VE, Kinzler KW, Vogelstein B, Gabelli SB, Amzel LM. "The structure of a human p110α/p85α complex elucidates the effects of oncogenic PI3Kα mutations." Science. 2007; 318(5857): 1744-8

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