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Abdel-Rahim A. Hamad, M.V.Sc., Ph.D.
Associate Professor of Pathology
Research Interests: Type 1 diabetes; NKT cells; DN T cells; Obesity
Dr. Abdel R Hamad, B.V.Sc, M.V.Sc, Ph.D, is an Associate Professor of Pathology and Medicine. Dr. Hamad earned his B.V.Sc and M.V.Sc in veterinary medicine from the University of Khartoum and his Ph.D in immunology from the University of Colorado Health Science Center. He completed his postdoctoral training here at Johns Hopkins University School of Medicine and joined the Faculty in 2002. Dr. Hamad’s research has been continuously funded by the NIH and by private funding societies.
Dr. Hamad's research is focused on understanding pathophysiological roles of non-conventional immune lymphocytes in the regulation of autoimmunity, particularly type 1 diabetes (T1D), obesity and type 2 diabetes. He is also actively studying the role of non-conventional T cells in the regulation of immune responses to ischemia reperfusion injury (IRI).
Currently, Dr. Hamad is working along with Dr. Thomas Donner, Director of Diabetes at Johns Hopkins Hospital to translate these findings into strategies to better identify and protect individuals at risk for developing T1D. Along the way, they identified a subset of B cells that expresses Fas ligand and appears to be significantly increased in T1D patients and to cause insulitis in animal models.
In addition, Dr. Hamad is collaborating with Dr. Hamid Rabb to understand the role of a unique population of T cells that we discovered and, based our data, appear to play critical roles in the prevention of ischemia reperfusion injury (IRI), a major cause of death of kidney transplant recipients.
Dr. Hamad and his colleagues have discovered that syndecan 1 (sdc1), a heparan sulfate proteoglycan, is a specific marker of a subset of natural killer T cells (NKT) that produces IL-17 and resides exclusively in visceral adipose tissues. Deletion of sdc1 significantly reduces body fat and improves glucose tolerance in mice. Currently, Dr. Hamad and his colleagues are investigating the underlying mechanisms and finding ways to translate these findings into therapeutic for obesity.
Dr. Hamad has coauthored over 40 peer-reviewed publications and a book chapter in the fields of autoimmune diabetes, immune homeostasis and regulation. Dr. Hamad is a member of the editorial board of World Journal of Diabetes and Topic editor for Frontier in Immunology. He is also active in federal government advisory committees. He is an appointed member of HAI study section and served as ad hoc reviewer for several NIH study sections and for the European Research Council. He is also a member of American Association of Immunologists and B cell working group of the JDRF Network of Pancreatic Organ donor (nPOD) and Appointed member of NIH HAI study section.
- Associate Professor of Pathology
- Associate Professor of Medicine
- M.V.Sc., University of Khartoum - Fac of Medicine - Khartoum - (Sudan) (1987)
- Ph.D., University of Colorado Health Science Center (Colorado) (1996)
Research & Publications
Lab Website: Hamad Laboratory
Selected PublicationsView all on Pubmed
Donner, T., S. Uddin, K. Arkara, Abdel Rahim Hamad. Potentials of FasL ligand (apoptosis inducing -molecule) as a unconventional therapeutic target in type 1 diabetes. Front Immunol. 2012; 3:196. doi: 10.3389/fimmu.2012.00196. Epub 2012 Jul 12
Martina MN, Noel S, Saxena A, Rabb H, Hamad AR. Double Negative (DN) αβ T Cells: Misperception and overdue recognition. Immunol Cell Biol. 93:305-10. 2015. PMID: 25420721
Saxena A, Khosraviani S, Noel S, Mohan D, Donner T, Hamad AR. Interleukin-10 paradox: A potent immunoregulatory cytokine that has been difficult to harness for immunotherapy. Cytokine 74(1):27-34. 2015. PMID: 25481648
Fousteri G, Ippolito E, Ahmed R, Hamad AR. Beta-cell specific autoantibodies: Are they just an indicator of type 1 diabetes? Curr Diabetes Rev. 2016. PMID: 27117244
AK Jaiswal, M Sadasivam, ARA Hamad. Syndecan-1-coating of interleukin-17-producing natural killer T cells provides a specific method for their visualization and analysis. World Journal of Diabetes 8 (4), 130. 2017. PMID: 28465789. PMCID: PMC5394732
Academic Affiliations & Courses
Graduate Program Affiliation
- Immunology Training program
- Pediatric training program
- Pathobiology graduate program
Courses and Syllabi
Pathology and Disease Mechanisms (PDM)
Immunology Core Course
Activities & Honors
- American Association of Immunologists (AAI), 1997
The American Association of Immunologists is an association of professionally trained scientists from all over the world dedicated to advancing the knowledge of immunology and its related disciplines, fostering the interchange of ideas and information among investigators, and addressing the potential integration of immunologic principles into clinical practice.
The American Association of Immunologists serves its members by providing a center for the dissemination of information relevant to the field and its practices, such as educational and professional opportunities, scientific meetings, membership-derived issues and opinions, and important social and political issues.
- JDRF/ Network of Pancreatic Organ Donor (nPOD), 2011