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Shiv Saidha, M.B.B.Ch.

Photo of Dr. Shiv Saidha, M.B.B.Ch.
4.9 out of 5
113 Ratings
| 59 Comments
  • Associate Professor of Neurology
Male

Expertise

Multiple Sclerosis, Neuroimmunology, Neurology

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Insurance Information

Maryland

410-614-1522
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Outside of Maryland

410-464-6641
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International Patients

+1-410-502-7683
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Locations

Johns Hopkins Outpatient Center

Appointment Phone: 410-614-1522
601 N. Caroline St.
Baltimore, MD 21287 map
Phone: 410-614-1522 | Fax: 410-502-6736

Background


Dr. Shiv Saidha specializes in the diagnosis, management, and treatment of multiple sclerosis (MS), as well as other neuroimmunological disorders of the central nervous system, including those afflicting the brain, spinal cord, and optic nerves.

Dr. Saidha received his medical degree, as well as his postgraduate Doctor of Medicine, from the National University of Ireland, Galway (NUIG), Ireland. He completed residency training in general internal medicine at Galway University Hospitals, Ireland. Subsequent to this he completed residency training in neurology at Galway, Cork, and Beaumont (located in Dublin) University Hospitals, Ireland. He then completed a further three years of specialized fellowship training in neuroimmunology & neuroinfectious diseases at Johns Hopkins University School of Medicine, Baltimore, Maryland.

Dr. Saidha’s research interests to date have predominantly focused on the non-invasive interrogation of retinal structures using optical coherence tomography (OCT) in multiple sclerosis (MS), in order to identify and investigate novel outcome strategies for assessing and monitoring neuroprotection and neurorestoration in MS, as well as to further our understanding of the pathobiology of MS, including how retinal pathology in MS may be related to more global central nervous system disturbances. He has been at the fore of discovering and demonstrating that inner and outer retinal layer pathology occur within the unmyelinated retina in MS (both quantitatively and qualitatively). He is committed to continuing to delineate and ascertain the mechanisms involved in the development of these findings, the clinical relevance of these changes (both locally in the retina, as well as more globally), and determine if this information may be used to guide the development of new, and potentially unique/novel effective MS therapies. His work to date has been primarily structurally focused (both within the retina using OCT, as well as more globally within the central nervous system through the assessment of brain substructure volumes, diffusion tensor imaging & magnetization transfer ratio metrics within specific pathways in MS). He also has expertise in the functional assessment of the anterior visual pathway in MS through the application of multifocal electroretinography and pupillometry techniques amongst others. He has published first author papers in Lancet, Lancet Neurology, Brain, Neurology, JAMA neurology, Archives of Neurology and Multiple Sclerosis Journal amongst authors.

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Education

Degrees

  • MB BCh BAO, National University of Ireland School of Medicine (2004)

Residencies

  • University College Hospital / Endocrinology (2005)
  • Merlin Park Hospital / Rheumatology (2005)
  • University College Hospital / Infectious Diseases (2006)
  • University College Hospital / Medical Oncology (2006)
  • University College Hospital / Neurology (2006)
  • Merlin Park Hospital / Nephrology (2007)
  • Merlin Park Hospital / Respiratory Therapy (2007)

Fellowships

  • Cork University Hospital / Neurology (2007)
  • Cork University Hospital (2008)
  • Cork University Hospital / Clinical Neurophysiology (2008)
  • Mercy University Hospital / Neurology (2008)
  • University College Hospital / Neurology (2009)
  • Johns Hopkins University School of Medicine / Neurology (2012)
  • Beaumont Hospital / Neurology (2013)

Research & Publications

Research Summary

Dr. Saidha's research interests to date have predominantly focused on the non-invasive interrogation of retinal structures using optical coherence tomography (OCT) in multiple sclerosis (MS), in order to identify and investigate novel outcome strategies for assessing and monitoring neuroprotection and neurorestoration in MS, as well as to further our understanding of the pathobiology of MS, including how retinal pathology in MS may be related to more global central nervous system disturbances. He has been at the fore of discovering and demonstrating that inner and outer retinal layer pathology occur within the unmyelinated retina in MS (both quantitatively and qualitatively). He is committed to continuing to delineate and ascertain the mechanisms involved in the development of these findings, the clinical relevance of these changes (both locally in the retina, as well as more globally), and determine if this information may be used to guide the development of new, and potentially unique/novel effective MS therapies. His work to date has been primarily structurally focused (both within the retina using OCT, as well as more globally within the central nervous system through the assessment of brain substructure volumes, diffusion tensor imaging & magnetization transfer ratio metrics within specific pathways in MS).

Selected Publications

Murphy O, Kwakyi O, Iftikhar M, Zafar S, Lambe J, Pellegrini N, Sotirchos E, Gonzalez-Caldito N, Ogbuokiri E, Filippatou A, Risher H, Cowley N, Feldman S, Fioravante N, Frohman EM, Frohman T, Balcer L, Prince J, Channa R, Calabresi P, Saidha S. Alterations in the retinal vasculature occur in multiple sclerosis and exhibit novel correlations with disability and visual function measures. (Multiple Sclerosis Journal. 2019 May 16)

Nguyen J, Rothman A, Caldito N, Avornu A, Ogbuokiri E, Balcer L, Galetta A, Frohman E, Frohman T, Crainiceanu C, Calabresi P, Saidha S. Macular ganglion cell and inner plexiform layer thickness is more strongly associated with visual function in multiple sclerosis than Bruch membrane opening minimum rim width or peripapillary retinal nerve fiber layer thicknesses. (Journal of Neuro-ophthalmology, 2019 Mar 26)

Nolan R, Liu M, Akhand O, Calabresi P, Paul F, Petzold A, Balk L, Brandt A, Martínez-Lapiscina E, Saidha S, Villoslada P, Al-Hassan A, Behbehani R, Frohman E, Frohman T, Havla J, Hemmer B, Jiang H, Knier B, Korn T, Leocani L, Papadopoulou A, Pisa M, Zimmermann H, Galetta SL, Balcer L; IMSVISUAL Consortium. Optimal Inter-Eye Difference Thresholds by OCT in MS: An International Study. (Annals of Neurology, 2019 Mar 9)

Liu Y, Carass A, He Y, Antony B, Filippatou A, Saidha S, Solomon S, Calabresi P, Prince J. Layer boundary evolution method for macular OCT layer segmentation. (Biomed Opt Express, 2019 Feb 4;10:1064-1080)

Rothman A, Murphy O, Fitzgerald K, Button J, Gordon-Lipkin E, Ratchford J, Newsome S, Mowry E, Sotirchos E, Syc-Mazurek S, Nguyen J, Caldito N, Balcer L, Frohman E, Frohman T, Reich D, Crainiceanu C, Saidha S, Calabresi P. Retinal measurements predict 10-year disability in multiple sclerosis. (Annals of Clinical and Translational Neurology, 2019 Jan 19;6:222-232)

Activities & Honors

Honors

  • Michael J O’ Donnell memorial prize, NUI Galway, 2008 - 2009
  • Awarded ECTRIMS/RIMS 2010 Travel Grant, ECTRIMS/RIMS
  • Awarded ECTRIMS/RIMS 2011 Travel Grant, ECTRIMS/RIMS
  • Awarded ECTRIMS/RIMS 2012 Travel Grant, ECTRIMS/RIMS
  • Awarded Teva Neuroscience 2011 Educational Grant, Teva
  • Director of the Johns Hopkins Neuroimmunology and neurological infections case conference program, Johns Hopkins, 2010 - 2012
  • Certified for EDSS examination, Neurostatus
  • Medical Director for anaccredited Continuing Medical Education program, Johns Hopkins School of Medicine
  • Medical Director for an accredited Continuing Medical Education program, University of Medicine and Dentistry of New Jersey (UMDNJ)
  • Prize for best oral presentation by a young investigator at ECTRIMS, Multiple Sclerosis International Federation (MSIF), 2010

Memberships

  • American Academy of Neurology (AAN)
    Member
  • Journal of Neurology, Neurosurgery & Psychiatry (JNNP), Journal of Neurology, European Journal of Neurology, PLoS ONE
  • New York Academy of Sciences (NYAS)
    Member

Videos & Media

Lectures and Presentations

  • In-vivo assessment of retinal axonal and neuronal integrity & pathology in MS with optical coherence tomography
    Neurology Grand Rounds, Zurich University (12/18/2012)
  • A novel retinal phenotype in multiple sclerosis is predictive of inflammatory disease activity and disability progression
    ECTRIMS (10/10/2012)
  • Optical Coherence Tomography as A Tool for Monitoring Changes and Treatment Effects in MS
    New York Academy of Sciences Conference on Imaging Neurodegeneration and repair in MS (06/15/2012)
  • In-vivo assessment of retinal axonal and neuronal integrity in MS with optical coherence tomography
    CMSC/ACTRIMS, University of Texas Southwestern (05/31/2012)
  • Novel optical coherence tomography techniques in MS; Emerging evidence for primary retinal neuronal mechanisms of pathology
    Neurology Grand Rounds (05/16/2012)
  • Clinical and radiological disease activity is associated with accelerated rates of retinal ganglion cell layer degeneration in multiple sclerosis
    AAN (04/24/2012)
  • Optical coherence tomography (OCT) of the eye; A window into the MS disease process
    United States Project Restore Board Meeting (03/30/2012)
  • Cross-sectional relationships between retinal segmentation and brain sub-structure volumes in multiple sclerosis
    ECTRIMS/ACTRIMS (10/20/2011)
  • Retinal neuronal loss in multiple sclerosis; Extending the utility of optical coherence tomography with retinal segmentation
    AAN (04/13/2011)
  • Primary retinal pathology in multiple sclerosis as detected by Optical Coherence Tomography
    ECTRIMS (10/13/2010)
  • Peri-procedural neuropathy; A retrospective review
    RAMI registrar prize (11/01/2008)
  • Another patient with A learning disability in decline?
    RAMI registrar prize (11/01/2008)
  • Bilateral brachial neuropathy and an unexpected aortic dissection; A case report
    Irish neuromuscular meeting (05/10/2008)
  • Multiple sclerosis presenting with parkinsonism; A case report
    Irish neurological association 44th annual meeting (05/08/2008)
  • Transverse Myelitis and Acute Motor axonal neuropathy
    RAMI registrar prize (11/01/2007)
  • Progressive encephalomyelitis with rigidity and autoimmune polyglandular syndrome; A case report
    Irish neurological association 42nd annual meeting (05/11/2006)

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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