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Tim Moran, Ph.D.

Timothy H. Moran, Ph.D.

Photo of Dr. Tim Moran, Ph.D.

Paul R. McHugh Professor of Motivated Behaviors

Professor of Psychiatry and Behavioral Sciences

Expertise: Eating Disorders, Obesity, Weight Disorders

Research Interests: Neural and Epigenetic Bases of Psychiatric Disorders; Obesity; Brain/Gut Interactions in the Controls of Food Intake ...read more

Background

Titles

  • Paul R. McHugh Professor of Motivated Behaviors
  • Executive Vice Chair
  • Director, Behavioral Neuroscience Laboratory
  • Director of Behavioral and Biological Research, Johns Hopkins Global Center for Obesity Prevention
  • Associate Director, Behavioral Core
  • Professor of Psychiatry and Behavioral Sciences

Departments / Divisions

Education

Additional Training

Johns Hopkins University School of Medicine, Baltimore, Maryland, 1982, Neurochemistry

Research & Publications

Research Summary

Our overall research program is aimed at identifying the roles of various neural signaling pathways in the controls of food intake and body weight and how these systems go awry in obesity and eating disorders.  Specific projects have focused on: brain/gut peptides as feedback mediators of satiety and how signals arising from these peptides interact with hypothalamic signaling systems mediating overall energy balance, interactions between exercise and food intake, how alterations in cellular energy availability and production result in signals that modify food intake, and how developmental and epigenetic factors can produce long term alterations in neural signaling that bias the organism’s long term metabolic phenotype. We conduct experiments at multiple levels using cell and rodent models as well as nonhuman primates and normal and patient populations. This work has resulted in over 325 original data articles, reviews and book chapters. 

Lab

His laboratory focuses on the controls of eating as they relate to the etiology of obesity and eating disorders. The laboratory uses multiple approaches including cell systems, genetic and dietary models of obesity in rodents, and analyses of feeding behavior in nonhuman primates. Specific projects involve examination of gut/brain in satiety, the role of hypothalamic neuropeptide systems in energy balance, interactions between energy expenditure and food intake and the identification of epigenetic factors that can bias the organism toward diabetes and obesity. His laboratory also studies developmental factors that can contribute to alterations in neural maturation.

Lab Website: Behavioral Neuroscience Laboratory

Selected Publications

View all on Pubmed

Chawla, A., Cordner, Z.A., Boersma, G. and Moran, T.H.: Cognitive impairment and gene expression alterations in a rodent model of binge eating disorder. Physiology and Behavior, 180: 78-90, 2017

Beheshti, R., Treesukosol, Y., Igusa, T. and Moran, T.H.: A predictive model of rats' calorie intake as a function of diet energy density. American Journal of Physiology, 315: R256-R266, 2018

Albertz, J., Boersma, G., Tamashiro, K.L.K. and Moran, T.H.: The effects of scheduled running wheel access on binge-like eating behavior and its consequences. Appetite, 126: 176-184, 2018

Treesukosol, Y., Inui-Yamamoto, C., Mikuta, H., Yamamoto, T., and Moran, T.H.: Short-term exposure to a calorically dense diet alters taste-evoked responses in the chorda tympani nerve, but not unconditioned lick responses to sucrose. Chemical Senses, 43: 433-441, 2018

Khambadkone, S., Cordner, Z., Dickerson, F., Severance, E., Prandovszky, E., Pletnikov, M., Xiao, J., Li, Y., Boersma, G., Talbot, C., Campbell, W., Wright, C., Siple, C., Moran, T.H., Tamashiro , K.L. and Yolken, R.: Nitrated meat products are,associated with mania in humans and altered behavior and brain gene expression in rats. Molecular Psychiatry, 2018

Contact for Research Inquiries

The Johns Hopkins University School of Medicine
Ross Building
720 Rutland Avenue
Baltimore, MD 21205 map
Phone: 410-955-2344

Academic Affiliations & Courses

Graduate Program Affiliation

Cellular and Molecular Medicine

Activities & Honors

Honors

  • 2013 Hoebel Creativity Award, Society for the Study of Ingestive Behavior, 2013
  • Adolf Meyer Fellowship, 1984
  • Paul R. McHugh Professorship in Motivated Behaviors, 2002
  • Fellow, Obesity Society, 2008
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