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Florin Marian Selaru, M.D.
Director, Meyerhoff Inflammatory Bowel Disease Center
Associate Professor of Medicine
Languages: English, Romanian
Expertise: Cholangiocarcinoma, Clinical Gastroenterology, Colitis, Crohn's Disease, Diarrhea, Digestive Disorders, Gastroenterology, Inflammatory Bowel Disease (IBD), Proctitis, Sclerosing Cholangitis, Ulcerative Colitis ...read more
Research Interests: Cancer development and progression in the gastrointestinal tract; Molecular changes associated with the transition from inflammatory states in the GI tract (colon, stomach, biliary tree) to frank cancers ...read more
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Dr. Selaru is currently an Associate Professor of Medicine and Oncology, Division of Gastroenterology and Hepatology and Sidney Kimmel Cancer Center, Johns Hopkins University. He is also a member of the Institute of Nanobiotechnology at Johns Hopkins University. Since its start in 2009, Dr. Selaru has also been directing his basic and applied science laboratory in cancer research at Johns Hopkins.
Dr. Selaru's focus is in bringing cutting edge molecular biology, genetics and engineering to the care of patients with gastroenterological disorders, in particular patients with GI cancers. His laboratory focuses on premalignant conditions such as colonic inflammation that can lead to colon cancer and inflammatory conditions of the hepatobiliary tract (such as primary sclerosing cholangitis or liver cirrhosis/fibrosis) that can lead to cholangiocarcinoma or hepatocellular cancer. The laboratory studies genetic alterations that can be utilized to understand disease progression from normal tissue to inflamed tissue to cancer, as well as to develop markers of early cancer. In addition, the laboratory focuses on epigenetic alterations, such as microRNA. Our recent studies demonstrated a rich, and previously unknown, intercellular communication between cancer cells and stroma, through small vesicles (exosomes) loaded with microRNA species. Last, the laboratory's focus is to bring microdevices and information technology to medicine.
Dr. Selaru's overarching goal is to deliver medical products and technologies to cancer patients, through an integrative approach that combines mathematics and data analysis, clinical gastroenterology, molecular and cell biology, engineering and business administration.
- Director, Meyerhoff Inflammatory Bowel Disease Center
- Associate Professor of Medicine
- Associate Professor of Oncology
Departments / Divisions
Centers & Institutes
- MD, Universitatea De Medicina Si Farmacie Carol Davila (1999)
- University of Maryland Medical Center / Internal Medicine (2006)
- University of Maryland Medical Center / Gastroenterology and Hepatology (2007)
- Johns Hopkins University School of Medicine / Gastroenterology (2009)
- American Board of Internal Medicine / Gastroenterology (2009)
Research & Publications
Dr. Selaru’s research interests comprise the molecular changes associated with the transition from inflammatory states in the GI tract (colon, stomach, biliary tree) to frank cancers. In addition, Dr. Selaru’s current research funded from the AGA, FAMRI and the Broad Foundation works to further the understanding of cancer development and progression in the gastrointestinal tract.
Videos & Media
Recent News Articles and Media Coverage
Hopkins Researchers Deliver Gene Therapy Directly to the Liver, Inside Tract (Fall 2018)
A Firmer Grip on Cancer Diagnosis, Inside Tract (Spring 2015)
For Health Care Providers: Johns Hopkins Clinical Connection A Revolutionary New Microbiopsy Device (Video)