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School of Medicine
James Peter Hamilton, M.D.
Assistant Professor of Medicine
Expertise: Fatty Liver, Gastroenterology, Hemochromatosis, Hepatitis, Hepatocellular Cancer, Jaundice, Liver Cancer, Liver Disease, Liver Mass, Liver Test Abnormalities, Liver Transplant, Liver Transplant Evaluation, Liver Tumors, Nonalcoholic Fatty Liver Disease, Sclerosing Cholangitis, Wilson Disease ...read more
Research Interests: Wilson Disease: Copper homeostasis and regulation of lipid metabolism and liver injury. Pathogenesis of Liver fibrosis and cancer; Early detection biomarker discovery for hepatocellular carcinoma ...read more
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Johns Hopkins Medicine - Green Spring Station
Appointment Phone: 410-933-7495
2360 W. Joppa Road
Lutherville, MD 21093 map
The Johns Hopkins Hospital (Main Entrance)
Appointment Phone: 410-933-7495
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map
Dr. Hamilton is an Assistant Professor of Medicine in the Division of Gastroenterology and Hepatology. He is the Program Director for the Transplant Hepatology Fellowship program, Associate Director of the Translational Research Enhancement Core of the JHU/NIH Digestive Disease Core, and the Co-Director of the GI/Liver section of the Genes to Society Medical School Curriculum.
His clinical specialties include Wilson Disease, Cystic Fibrosis related liver disease, liver transplantation, hepatocellular carcinoma, cirrhosis, portal hypertension, acute and chronic viral, non-alcoholic fatty liver disease (NASH), autoimmune, and cholestatic liver disease.
His research interests include the copper homeostasis and its regulation of lipid metabolism and liver injury, the fundamental mechanisms regulating liver fibrosis, and the molecular genetics of hepatocellular carcinoma and early detection biomarkers.
Dr. Hamilton is a 2005 recipient of the National Institutes of Health/ National Research Scholar Award for gastroenterology and hepatology.
- Assistant Professor of Medicine
Centers & Institutes
- MD; Medicine, University of Maryland School of Medicine (2000)
- McGaw Medical Center of Northwestern University - GME / Internal Medicine (2003)
- University of Maryland Medical Center / Gastroenterology (2006)
- Johns Hopkins University School of Medicine / Gastroenterology (2007)
- American Board of Internal Medicine / Gastroenterology (2017)
- American Board of Internal Medicine / Transplant Hepatology (2008)
Research & Publications
A Phase 3, Double-Blind Randomized, Long-term, Placebo-controlled, Multicenter Study Evaluating the Safety and Efficacy of Obeticholic Acid (OCA) in subjects with Non-Alcoholic Steatohepatitis (REGENERATE)
A Phase 2, Double-blind, Randomized, Placebo-controlled, Dose-finding Study to Evaluate the Safety, Tolerability and Efficacy of Volixibat Potassium, an Apical Sodium-Dependent Bile Acid Transporter Inhibitor (ASBTi) in Adults with Nonalcoholic Steatohepatitis (NASH)
Sofusbuvir and Ledipasvir in HIV/HCV Coinfected Pre and Post Liver Transplant
A Phase II Randomized Multicenter Placebo-Controlled Blinded Study of Sorafenib Adjuvant Therapy in High Risk Orthotopic Liver Transplant (OLT) Recipients with Hepatocellular Carcinoma (HCC)
Hamilton JP, Potter JJ, Koganti L, Meltzer SJ, Mezey E. Effects of Vitamin D stimulation of Thioredoxin Interacting Protein in hepatocellular carcinoma. Hepatol Res. 2014; 44(13): 1357-66. PMID: 24451003
Karthikeyan S, Potter JJ, Geschwind JF, Sur S, Hamilton JP, Vogelstein B, Kinzler KW, Mezey E, Gaganpathy-Kanniappan S. Deregulation of energy Metabolism Promotes Antfibrotic Effects in Human Hepatic Stellate Cells and Prevents Liver Fibrosis in a Mouse Model. Biochem Biophys Res Comm 2016; 469(3): 463-9. PMID: 26525850
Hamilton JP, Koganti L, Muchenditsi A, Pendyala VS, Huso D, Hankin J, Murphy RC, Huster D, Merle U, Mangels C, Yang N, Potter JJ, Mezey E, Lutsenko S. Activation of LXR/RXR Pathway Ameliorates Liver disease in ATP7b-/- (Wilson disease) mice. Hepatology 2016; 63(6): 1828-41. PMID: 26679751
Oh Y, Park O, Swierczewska M, Hamilton JP, Park JS, Kim TH, Lim SH, Eom H, Jo DG, Lee CE, Kechrid R, Mastorakos P, Zhang C, Hahn SK, Jeon OC, Byun Y, Km K, Hanes J, Lee KC, Pomper MG, Gao B, Lee S. Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating hepatic stellate cells. Hepatology 2016; 64(1): 209-23. PMID: 26710118
Contact for Research Inquiries
720 Rutland Ave
Baltimore, MD 21205 map
Activities & Honors
- Research Fellowship, NRSA
- Top Doctor, Baltimore Magazine, 2018 - 2018