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Lei Zheng, M.D., Ph.D.

Photo of Dr. Lei Zheng, M.D., Ph.D.
  • Associate Professor of Oncology

Languages: English, Chinese


Anal Cancer, Bile Duct Cancer, Carcinoid Syndrome, Carcinoid Tumors, Cholangiocarcinoma, Colon Cancer, Colorectal Cancer, Gastric Cancer, Gastroesophageal Junction Cancer, Gastrointestinal Cancers, Gastrointestinal Tumors, Hepatocellular Cancer, Liver Cancer, Medical Oncology, Neuroendocrine Tumors, Pancreatic Cancer, Peri-Ampullar Cancer, Rectal Cancer, Small Bowel Cancer, Small Intestine Cancer, Stomach Cancer more

Research Interests

Pancreatic cancer biology and translational research; translational immunology and cancer immunotherapy; tumor microenvironment; cancer invasion and metastasis; clinical and translation research of gastrointestinal malignancies. more

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Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Appointment Phone: 410-955-8964
401 N. Broadway
Baltimore, MD 21231 map



  • Associate Professor of Oncology
  • Associate Professor of Surgery

Departments / Divisions

Centers & Institutes



  • MD, Peking Union Medical College Beijing (1996)


  • Long Island Jewish Medical Center / Internal Medicine (2006)


  • Johns Hopkins University School of Medicine / Medical Oncology (2009)

Board Certifications

  • American Board of Internal Medicine / Internal Medicine (2006)
  • American Board of Internal Medicine / Medical Oncology (2008)

Research & Publications

Lab Website: Lei Zheng Lab

Selected Publications

Zheng L, Pan H, Li S, Flesken-Nikitin A, Chen PL, Boyer TG, Lee WH. Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. Mol Cell. 2000;6(4):757-68.

Zheng L, Roeder RG, Luo Y. S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component. Cell. 2003;114(2):255-66.

Lutz ER, Wu AA, Bigelow E, Sharma R, Mo G, Soares K, Solt S, Dorman A, Wamwea A, Yager A, Laheru D, Wolfgang CL, Wang J, Hruban RH,. Anders RA, Jaffee EM, Zheng L. Immunotherapy Converts Non-immunogenic Pancreatic Tumors into Immunogenic Foci of Immune Regulation. Cancer Immunology Research 2014;2(7):1-16. (Corresponding author). PMCID: PMC4082460

Foley K, Rucki AA, Xiao Q, Zhou D, Leubner A, Mo G, Kleponis J, Wu AA, Sharma R, Jiang Q, Anders RA, Iacobuzio-Donahue CA, Hajjar KA, Maitra A, Jaffee EM, Zheng L. Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer. Science Signaling 2015; 8(388):ra77. (Corresponding author) PMCID in progress.

Soares KC, Rucki AA, Wu AA, Olino K, Xiao Q, Chai Y, Wamwea A, Bigelow E, Lutz E, Liu L, Yao S, Anders AA, Laheru D, Wolfgang CL, Edil BH, Schulick RD, Jaffee EM, Zheng L. PD-1/PD-L1 blockade together with vaccine therapy facilitates effector T cell infiltration into pancreatic tumors. Journal of Immunotherapy 2015;38(1):1-11. (Corresponding author). PMCID: PMC4258151

Videos & Media

Recent News Articles and Media Coverage

Pancreatic Cancer and Immunotherapy Trials, Johns Hopkins Surgery (5/3/2017)

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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