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Oscar Cingolani, M.D.
Oscar Horacio Cingolani, M.D.
Director, Hypertension Program
Associate Professor of Medicine
Languages: English, Spanish
Expertise: Cardiac Intensive Care Unit, Cardiology, Cardiovascular Disease, Cardiovascular Diseases, Coronary Artery Disease, Echocardiography, Heart Disease, Heart Failure, High Cholesterol, Hypertension, Valvular Heart Disease, Venous Thromboembolism ...read more
Research Interests: Heart Failure; Hypertension; Matricellular Proteins in cardiovascular Diseases.; Cardiac regeneration; Atrial fibrillation
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Dr. Cingolani is an Associate Professor at The Johns Hopkins University School of Medicine, Division of Cardiology. He earned his medical degree from Universidad Nacional de La Plata, Argentina, and completed his Internship and Internal Medicine Residency at CEMIC, Buenos Aires, Argentina, and hypertension research post-doctoral fellowship at Henry Ford Hospital, Detroit, MI. After completing his Internal Medicine Residency at The Reading Hospital and Medical Center in Pennsylvania, Dr. Cingolani joined The Johns Hopkins Hospital as a Cardiology fellow, where he remained in the Faculty after his training.
Currently, he is the Associate Director of The Johns Hopkins Hospital Coronary Care Unit, Director of the Hypertension Center and member of the Echocardiography Lab and Outpatient Cardiology Clinic. He also teaches pathophysiology to medical students.
Dr. Cingolani’s research interests focus on hypertensive heart disease and its transition to heart failure. He aims to elucidate the mechanism/s by which certain matricellular proteins present in the heart seem to play a protective role. His research is mainly supported by the National Institute of Health (NIH).
He is also the principal investigator of the DREAM study group, studying the effect of Melatonin in preventing atrial fibrillation in patients undergoing cardiac surgery.
Dr. Cingolani has been recognized by the Council for High Blood Pressure Research of the American Heart Association for his work in hypertension and is the 2011 recipient of the PJ Schafer Memorial Heart Research Award, the 2012 Michel Mirowski Discovery Fund Award, and 2013 Magic that matters Fund. He is board-certified in Internal Medicine and Cardiovascular Diseases.
- Director, Hypertension Program
- Associate Director, Coronary Care Unit
- Osler Internal Medicine Faculty (Thayer Firm)
- Associate Professor of Medicine
Centers & Institutes
- MD, Facultad de Ciencias Medicas (1992)
- CEMIC / Hypertension (2001)
- Reading Hospital and Medical Center / Internal Medicine (2005)
- Johns Hopkins University School of Medicine / Cardiology (2009)
- American Board of Internal Medicine / Cardiovascular Disease (2009)
Research & Publications
Pricipal Investigator in DREAM Study: Effect of Melatonin in preventing atrial fibrillation in patients undergoing cardiac surgery
Activities & Honors
- The Council for High Blood Pressure Research Award, American Heart Association, 2002
- The Council for High Blood Pressure Research Award, American Heart Association, 2003
- PJ Schafer Memorial Heart research Award, Johns Hopkins University, 2011
- The Michel Mirowski Discovery Fund Award, Johns Hopkins University, 2012
- The Magic that Matters Fund Award, Johns Hopkins University, 2013
- American Heart Association
- Council for High Blood Pressure Research, AHA
- Reviewer, Circulation Research
- Reviewer, Hypertension
- Reviewer, Heart
- Reviewer, American Journal of Physiology
- Reviewer, Journal of the American College of Cardiology
Videos & Media
Recent News Articles and Media Coverage
1- Cingolani OH, Heath J, McDonald M. A Nervous Heart. Circulation. 2014. In press.
2- Seo K, Rainer PP, Lee DI, Hao S, Bedja D, Birnbaumer L, Cingolani OH, Kass DA. Hyperactive Adverse Mechanical-Stress Responses in Dystrophic Heart are Coupled to TRPC6 and Blocked by cGMP-PKG Modulation. Circ Res. 2014. Jan 21.
3- Gilotra NA, Chow GV, Cingolani OH. Cardiac amyloidosis presenting with a prolonged QT interval and recurrent polymorphic ventricular tachycardia. Tex Heart Inst J 2013;40(2) 193-5.
4- Cingolani HE, Perez NG, Cingolani OH, Ennis IL. The Anrep effect: 100 years later. Am J Physiol Heart Circ Physiol. 2013 Jan 15; 304(2):H175-82.
5- Niu X, Watts VL, Cingolani OH, Sivakumaran V, Leyton-Mange JS, Ellis CL, Miller KL, Vandegaer K, Bedja D, Gabrielson KL, Paolocci N, Kass DA, Barouch LA. Cardioprotective effect of beta-3 adrenergic receptor agonism: role of neuronal nitric oxide synthase. J Am Coll Cardiol. 2012 may 29; 59(22) 1979-87.
6- Tedford RJ, Hassoun PM, Mathai SC, Girgis RE, Russell SD, Thiemann DR, Cingolani OH, Mudd JO, Borlaug BA, Redfield MM, Lederer DJ, Kass DA. Pulmonary Capillary Wedge Pressure Augments Right Ventricle Pulsatile Loading. Circulation. 2011 Nov 30.
7- Cingolani OH, Kirk JA, Seo K, Koitabashi N, Lee DI, Ramirez-Correa G, Bedja D, Barth AS, Moens AL, Kass DA. Thrombospondin-4 is Required for Stretch-Mediated Contractility Augmentation in Cardiac Muscle. Circ Res. 2011 Oct 27.
8- Cingolani OH, Kass DA. Pressure-Volume Relation Analysis of Mouse Ventricular Function. Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2198-206.
9- Cingolani OH, Pérez NG, Ennis IL, Alvarez MC, Mosca SM, Schinella GR, Escudero EM, Cónsole G, Cingolani HE. In vivo key role of reactive oxygen species and NHE-1 activation in determining excessive cardiac hypertrophy. Pflugers Arch. 2011 Nov;462(5):733-43.
10- Ketlogetswe KS, Aoki J, Traill TA, Cingolani OH. Severe Aortic regurgitation Secondary to Antisynthetase Syndrome. Circulation. 2011 Jul 19;124(3):e40-1.
11- Cingolani OH, Kaludercic N, Paolocci N. Sexual dimorphism in cardiac norepinephrine spillover: a NET difference. Heart. 2011 Mar;97(5):347-9.
12- Cingolani OH, Pérez NG, Cingolani HE. Letter by Cingolani et al regarding article, "Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice".
13- Moens AL, Leyton-Mange JS, Niu X, Yang R, Cingolani O, Arkenbout EK, Champion HC, Bedja D, Gabrielson KL, Chen J, Xia Y, Hale AB, Channon KM, Halushka MK, Barker N, Wuyts FL, Kaminski PM, Wolin MS, Kass DA, Barouch LA. Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoceptor. J Mol Cell Cardiol. 2009 Nov;47(5):576-85.
14- Maloyan A, Osinska H, Lammerding J, Lee RT, Cingolani OH, Kass DA, Lorenz JN, Robbins J. Biochemical and Mechanical Dysfunction in a Mouse Model of Desmin-Related Myopathy. Circ Res. 2009 Apr 24;104(8):1021-8.
15- Donato A, Cingolani OH. Lemierre Syndrome. Consultant. April 1, 2008. Vol 48 NO. 4.
16-Pérez NG, Piaggio MR, Ennis IL, Garciarena CD, Morales C, Escudero EM, Cingolani OH, Chiappe de Cingolani G, Yang XP, Cingolani HE. Phosphodiesterase 5A Inhibition Induces Na+/H+ Exchanger Blockade and Protection Against Myocardial Infarction. Hypertension. 2007 May; 49(5):1095-103.
17- Cingolani OH. Cardiac Hypertrophy and the Wnt/Frizzled Pathway. Hypertension. 2007; 49:427 [Editorial].
18- Liu YH, Carretero OA, Cingolani OH, Liao TD, Sun Y, Xu J, Li LY, Pagano PJ, Yang JJ, Yang XP. Role of inducible nitric oxide synthase in cardiac function and remodeling in mice with heart failure due to myocardial infarction.Am J Physiol Heart Circ Physiol. 2005 Dec; 289(6): H2616-23.
19- Yang F, Yang XP, Liu YH, Xu J, Cingolani OH, Rhaleb NE, Carretero OA. Ac-SDKP Reverses Inflammation and Fibrosis in Rats With Heart Failure Post-Myocardial Infarction. Hypertension. 2004 43: 229-236.
20- Cingolani OH. Yang X-P, Liu Y-H, Carretero OA. Reduction of Cardiac Fibrosis Reduces Systolic Performance Without Affecting Diastolic Function in Hypertensive Rats. Hypertension. 2004 May; 43(5):1067-73.
21- Di Gennaro F, Cingolani OH, Abbate A, Toblli J, Vilches A. Effect of High Doses of Aspirin on Blood Pressure in Hypertensive Patients Treated with Enalapril. Medicina (Buenos Aires). 2004; 64: 301-305
22- Cingolani OH. Yang X-P, Cavasin MA, Carretero OA, Increased systolic performance with diastolic dysfunction in adult spontaneously hypertensive rats. Hypertension. 2003; 41: 249-254.
23- Ridruejo E, Laurini J, Cingolani, OH. Fulminant Hepatic Failure. Atipical Presentation for Congestive Heart Failure. [Span]. Medicina (Buenos Aires) 60: 491-494, 2000.