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Una D McCann, M.D.

Photo of Dr. Una D McCann, M.D.
  • Associate Program Director JHBMC GCRC
  • Professor of Psychiatry and Behavioral Sciences

Languages: English, Spanish


Adult Psychiatry, Anxiety Disorders, Obsessive-Compulsive Disorders, Post Traumatic Stress, Psychiatry, Psychiatry and Behavioral Sciences

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Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-1933
5500 Lombard Street
Baltimore, MD 21224 map

The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-955-5104
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map



  • Associate Program Director JHBMC GCRC
  • Director, Anxiety Disorders Program
  • Professor of Psychiatry and Behavioral Sciences
  • Professor of Neurology

Departments / Divisions

Centers & Institutes



  • MD, Duke University School of Medicine (1984)


  • Stanford University School of Medicine / Psychiatry (1988)


  • Stanford University School of Medicine / Psychiatry (1988)

Board Certifications

  • American Board of Psychiatry And Neurology / Psychiatry (1990)

Research & Publications

Research Summary

My two active areas of research are in the areas of amphetamine-induced monoamine neurotoxicity (i.e., MDMA, Methamphetamine, ephedrine or amphetamine-induced monoaminergic neurotoxicity), and the neurobiology of anxiety disorders. Methods used in both research spheres include neuropharmacology, PET, MRI, fMRI, polysomnography, pharmacological challenge, and neuropsychiatric assessment. Studies of amphetamine neurotoxicity also include preclinical studies using microarrays, cell culture, rodents and primates.

Core Facility: Interdisciplinary Sleep, Research and Education (CISRE), Center for

Selected Publications

  1. McCann UD, Szabo Z, Scheffel U, Matthews WB, Dannals RF, Ravert HT, Musachio JL, Mertl MM, Ricaurte GA. Positron Emission Tomographic evidence of toxic effect of MDMA (AEcstasy@) on brain serotonin neurons in humans beings, The Lancet, 1998; 352:1433-1437.
  2. McCann UD, Wong DF, Villemagne V, Dannals RF, Ricaurte GA. Brain dopamine neurotoxicity in abstinent methamphetamine and methcathinone users: Evidence from PET studies with [11C]WIN- 35,428, Journal of Neuroscience 1998;18(20):8417-8422.
  3. McCann UD, Mertl MM, Eligulashvili V, Ricaurte GA. Cognitive performance in () 3,4- methylenedioxymethamphetamine (MDMA, "ecstasy") users: A controlled study, Psychopharmacology, 1999; 143:417-425
  4. McCann UD, Slate SO, Geraci M, Roscow-Terrill D, and Uhde TW. A comparison of the effects of intravenous pentagastrin in patients with social phobia, panic disorder, and healthy volunteers, Neuropsychopharmacology, 1997;16(3):229-237.
  5. Geraci M, Anderson TS, Slate-Cothren S, Post RM, McCann UD. Pentagastrin-induced sleep panic attacks: Panic in the absence of elevated baseline arousal. Biological Psychiatry, 2002;52(12):1183-9.

Videos & Media

Recent News Articles and Media Coverage

Hopkins Brain Wise Newsletter articles about Dr. McCann's work:

Translations: Model of a Muddle

Look What They’ve Done to Their Brains

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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