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Peter Joseph Mogayzel, Jr, M.D., Ph.D.
Director, Cystic Fibrosis Center
Professor of Pediatrics
Expertise: Cystic Fibrosis, Pediatric Pulmonary Medicine, Pulmonary Medicine
Research Interests: Cystic fibrosis; Regulation of cystic fibrosis transmembrane conductance regulator (CFTR) gene expression; Development of new therapeutics for cystic fibrosis; Infant pulmonary function testing; Mucociliary clearance and lung defense mechanisms ...read more
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Johns Hopkins Pediatrics
APPOINTMENT PHONE: 410-955-2795
200 N. Wolfe Street Rubenstein Child Health Building Baltimore, MD 21287
Johns Hopkins Children's Center Pediatric Specialists
APPOINTMENT PHONE: 443-997-5437
820 Best Gate Road Suite 2D Annapolis, MD 21401
Dr. Peter Mogayzel is a professor of pediatrics at the Johns Hopkins University School of Medicine. His areas of clinical expertise include pediatric pulmonary medicine and the treatment of cystic fibrosis. He has served as the director of the Johns Hopkins Cystic Fibrosis Center since 2002.
Dr. Mogayzel attended Brown University and received his M.D. and Ph.D. degrees from Boston University and an M.B.A. from Johns Hopkins University. He completed his pediatric residency at the University of Washington, and finished pediatric pulmonary and pediatric critical care fellowships at Johns Hopkins in 1998 before joining the faculty.
His research interests include the regulatory properties of the CFTR gene, mucociliary clearance and development of new therapeutics for cystic fibrosis.
Dr. Mogayzel is a fellow of American College of Chest Physicians and the American Academy of Pediatrics, and a member of several societies including the American Thoracic Society.
He has published many journal articles and several book chapters on a variety of topics related to cystic fibrosis. Dr. Mogayzel is an ad hoc reviewer for several journals, including the Journal of Cystic Fibrosis and American Journal of Respiratory and Critical Care Medicine. He serves as chairman of the Clinical Practice Guidelines for Pulmonary Therapies Committee and the Therapeutic Development Network Protocol Review Committee, both of the Cystic Fibrosis Foundation. He is also a past chairman of the Cystic Fibrosis Foundation Center Committee that accredits cystic fibrosis centers in the U.S.
- Director, Cystic Fibrosis Center
- Medical Director, Pediatric Specialty Clinic
- Professor of Pediatrics
- MD, Boston University School of Medicine (1990)
- University of Washington Medical Center / Pediatrics (1993)
- Johns Hopkins University School of Medicine / Pediatric Pulmonary Medicine (1998)
- American Board of Pediatrics / Pediatric Pulmonology (1998)
Research & Publications
Dr. Mogayzel’s research interests include the regulatory properties of the CFTR gene, mucociliary clearance and development of new therapeutics for cystic fibrosis.
Clinical Trial KeywordsCystic Fibrosis
Mogayzel PJ Jr, Naureckas ET, Robinson KA, Brady C, Guill M, Lahiri T, Lubsch L, Matsui J, Oermann CM, Ratjen F, Rosenfeld M, Simon RH, Hazle L, Sabadosa K, Marshall BC; Cystic Fibrosis Foundation Pulmonary Clinical Practice Guidelines Committee. "Cystic Fibrosis Foundation pulmonary guideline. Pharmacologic approaches to prevention and eradication of initial Pseudomonas aeruginosa infection." Ann Am Thorac Soc. 2014 Dec;11(10):1640-50. doi: 10.1513/AnnalsATS.201404-166OC. PubMed PMID: 25549030.
Do R, Stitziel NO, Won HH, Jørgensen AB, Duga S, Angelica Merlini P, Kiezun A, Farrall M, Goel A, Zuk O, Guella I, Asselta R, Lange LA, Peloso GM, Auer PL; NHLBI Exome Sequencing Project, Girelli D, Martinelli N, Farlow DN, DePristo MA, Roberts R, Stewart AF, Saleheen D, Danesh J, Epstein SE, Sivapalaratnam S, Hovingh GK, Kastelein JJ, Samani NJ, Schunkert H, Erdmann J, Shah SH, Kraus WE, Davies R, Nikpay M, Johansen CT, Wang J, Hegele RA, Hechter E, Marz W, Kleber ME, Huang J, Johnson AD, Li M, Burke GL, Gross M, Liu Y, Assimes TL, Heiss G, Lange EM, Folsom AR, Taylor HA, Olivieri O, Hamsten A, Clarke R, Reilly DF, Yin W, Rivas MA, Donnelly P, Rossouw JE, Psaty BM, Herrington DM, Wilson JG, Rich SS, Bamshad MJ, Tracy RP, Cupples LA, Rader DJ, Reilly MP, Spertus JA, Cresci S, Hartiala J, Tang WH, Hazen SL, Allayee H, Reiner AP, Carlson CS, Kooperberg C, Jackson RD, Boerwinkle E, Lander ES, Schwartz SM, Siscovick DS, McPherson R, Tybjaerg-Hansen A, Abecasis GR, Watkins H, Nickerson DA, Ardissino D, Sunyaev SR, O'Donnell CJ, Altshuler D, Gabriel S, Kathiresan S. "Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction." Nature. 2015 Feb 5;518(7537):102-6. doi: 10.1038/nature13917. Epub 2014 Dec 10. PubMed PMID: 25487149; PubMed Central PMCID: PMC4319990.
Tabor HK, Auer PL, Jamal SM, Chong JX, Yu JH, Gordon AS, Graubert TA, O'Donnell CJ, Rich SS, Nickerson DA; NHLBI Exome Sequencing Project, Bamshad MJ. "Pathogenic variants for Mendelian and complex traits in exomes of 6,517 European and African Americans: implications for the return of incidental results." Am J Hum Genet. 2014 Aug 7;95(2):183-93. doi: 10.1016/j.ajhg.2014.07.006. Epub 2014 Jul 31. PubMed PMID: 25087612; PubMed Central PMCID: PMC4129409.
Gutierrez HH, Mogayzel PJ Jr. "ESCF care guidelines beyond Europe." J Cyst Fibros. 2014 Jul;13(4):359-60. doi: 10.1016/j.jcf.2014.05.002. Epub 2014 May 28. PubMed PMID: 24880532.
Paranjape SM, Mogayzel PJ Jr. "Cystic fibrosis." Pediatr Rev. 2014 May;35(5):194-205. doi: 10.1542/pir.35-5-194. Erratum in: Pediatr Rev. 2014 Jun;35(6):228. PubMed PMID: 24790073.
Mogayzel PJ Jr, Dunitz J, Marrow LC, Hazle LA. "Improving chronic care delivery and outcomes: the impact of the cystic fibrosis Care Center Network." BMJ Qual Saf. 2014 Apr;23 Suppl 1:i3-8. doi: 10.1136/bmjqs-2013-002363. PubMed PMID: 24608548.
Lange LA, Hu Y, Zhang H, Xue C, Schmidt EM, Tang ZZ, Bizon C, Lange EM, Smith JD, Turner EH, Jun G, Kang HM, Peloso G, Auer P, Li KP, Flannick J, Zhang J, Fuchsberger C, Gaulton K, Lindgren C, Locke A, Manning A, Sim X, Rivas MA, Holmen OL, Gottesman O, Lu Y, Ruderfer D, Stahl EA, Duan Q, Li Y, Durda P, Jiao S, Isaacs A, Hofman A, Bis JC, Correa A, Griswold ME, Jakobsdottir J, Smith AV, Schreiner PJ, Feitosa MF, Zhang Q, Huffman JE, Crosby J, Wassel CL, Do R, Franceschini N, Martin LW, Robinson JG, Assimes TL, Crosslin DR, Rosenthal EA, Tsai M, Rieder MJ, Farlow DN, Folsom AR, Lumley T, Fox ER, Carlson CS, Peters U, Jackson RD, van Duijn CM, Uitterlinden AG, Levy D, Rotter JI, Taylor HA, Gudnason V Jr, Siscovick DS, Fornage M, Borecki IB, Hayward C, Rudan I, Chen YE, Bottinger EP, Loos RJ, Sætrom P, Hveem K, Boehnke M, Groop L, McCarthy M, Meitinger T, Ballantyne CM, Gabriel SB, O'Donnell CJ, Post WS, North KE, Reiner AP, Boerwinkle E, Psaty BM, Altshuler D, Kathiresan S, Lin DY, Jarvik GP, Cupples LA, Kooperberg C, Wilson JG, Nickerson DA, Abecasis GR, Rich SS, Tracy RP, Willer CJ; NHLBI Grand Opportunity Exome Sequencing Project. "Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol." Am J Hum Genet. 2014 Feb 6;94(2):233-45. doi: 10.1016/j.ajhg.2014.01.010. PubMed PMID: 24507775; PubMed Central PMCID: PMC3928660.
Laube BL, Sharpless G, Benson J, Carson KA, Mogayzel PJ Jr. "Mucus removal is impaired in children with cystic fibrosis who have been infected by Pseudomonas aeruginosa." J Pediatr. 2014 Apr;164(4):839-45. doi: 10.1016/j.jpeds.2013.11.031. Epub 2013 Dec 24. PubMed PMID: 24373575.
Gordon AS, Tabor HK, Johnson AD, Snively BM, Assimes TL, Auer PL, Ioannidis JP, Peters U, Robinson JG, Sucheston LE, Wang D, Sotoodehnia N, Rotter JI, Psaty BM, Jackson RD, Herrington DM, O'Donnell CJ, Reiner AP, Rich SS, Rieder MJ, Bamshad MJ, Nickerson DA; NHLBI GO Exome Sequencing Project. "Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset." Hum Mol Genet. 2014 Apr 15;23(8):1957-63. doi: 10.1093/hmg/ddt588. Epub 2013 Nov 26. PubMed PMID: 24282029; PubMed Central PMCID: PMC3959810.
Rosenthal EA, Ranchalis J, Crosslin DR, Burt A, Brunzell JD, Motulsky AG, Nickerson DA; NHLBI GO Exome Sequencing Project, Wijsman EM, Jarvik GP. "Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia." Am J Hum Genet. 2013 Dec 5;93(6):1035-45. doi: 10.1016/j.ajhg.2013.10.019. Epub 2013 Nov 21. PubMed PMID: 24268658; PubMed Central PMCID: PMC3852929.
Activities & Honors
- Fellow, American College of Chest Physicians
- Fellow, American Academy of Pediatrics
- Member, American Thoracic Society
- Chairman, Clinical Practice Guidelines for Pulmonary Therapies Committee, Cystic Fibrosis Foundation
- Chairman, Therapeutic Development Network Protocol Review Committee, Cystic Fibrosis Foundation