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Lawrence Mark Nogee, M.D.

Photo of Dr. Lawrence Mark Nogee, M.D.
  • Director, Neonatal-Perinatal Fellowship Training Program
  • Professor of Pediatrics
Male

Expertise

Neonatal-Perinatal Medicine, Neonatology

Research Interests

Interstitial lung disease; Childhood interstitial lung disease; Genetic surfactant dysfunction disorders; Neonatal lung disease

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Insurance Information

Maryland

410-955-5259

Outside of Maryland

410-464-6641
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International Patients

+1-410-502-7683
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Locations

The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-955-5259
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-614-3355 | Fax: 410-614-8388

Background

Dr. Lawrence Nogee is a professor of pediatrics at the Johns Hopkins University School of Medicine. His area of clinical expertise is neonatology, with a particular focus on genetic surfactant dysfunction disorders and neonatal lung disease. 

Dr. Nogee received his medical degree at the Johns Hopkins University School of Medicine in 1981. He went on to complete a residency in pediatrics in 1984, also at Johns Hopkins.

His research focuses on genetic causes of neonatal lung disease and childhood interstitial lung disease (chILD), a group of poorly understood illnesses that cause chronic breathing problems in children, often starting in infancy and leading to progressive lung damage.

Dr. Nogee has over 100 publications in peer-reviewed journals. He holds certifications in neonatal and perinatal medicine and in pediatrics from the American Board of Pediatrics.

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Titles

  • Director, Neonatal-Perinatal Fellowship Training Program
  • Interim Director, Eudowood Neonatal Pulmonary Division
  • Interim Director, Division of Neonatology
  • Professor of Pediatrics

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MD, Johns Hopkins University School of Medicine (1981)

Residencies

  • Johns Hopkins University School of Medicine / Pediatrics (1984)

Fellowships

  • Cincinnati Childrens Hospital Medical Center / Neonatal Perinatal Medicine (1988)

Board Certifications

  • American Board of Pediatrics / Neonatal-Perinatal Medicine (1987)
  • American Board of Pediatrics / Pediatrics (1986)

Research & Publications

Research Summary

Lawrence Nogee’s clinical and research interests are in lung diseases in newborns as well as older children, with a particular focus on genetic lung diseases. His laboratory research focuses on identifying genetic mechanisms leading to neonatal respiratory failure and diffuse and interstitial lung diseases in older infants and children. This includes understanding the biology, molecular epidemiology and pathophysiology of lung diseases due to genetic surfactant dysfunction through molecular and genetic analyses of samples from individuals with these rare lung disorders.

In addition, his laboratory actively seeks to identify novel genetic causes of childhood interstitial lung disorders, determine the role of genetic variants in surfactant-related genes in contributing to more common neonatal lung diseases, and use the study of these disorders to improve our understanding of normal surfactant metabolism. Long-term goals include translating basic science findings into improved diagnostic tests for rare neonatal and diffuse lung disease, and developing more effective therapies for these disorders, and he is part of a multicenter collaboration to develop specific therapy for ABCA3 deficiency, the most common cause of genetic surfactant dysfunction.

Dr. Nogee is an active participant in the Children’s Interstitial Lung Disease Research Network (ChILDRN) and part of the Johns Hopkins Center for Pulmonary Hypertension and Congenital Diaphragmatic Hernia working groups, is a site co-investigator on a multicenter trial of treprostinil as add-on therapy for persistent pulmonary hypertension of the newborn, and a co-investigator on the NIH-funded trial evaluating serial amnioinfusions to rescue the lethal pulmonary hypoplasia associated with early-onset anhydramnios (PI: Eric Jelin, general pediatric surgery).  

Selected Publications

Wambach JA, Casey AM, Fishman MP, Wegner DJ, Wert SE, Cole FS, Hamvas A, Nogee LM. "Genotype-phenotype correlations for infants and children with ABCA3 deficiency." Am J Respir Crit Care Med. 2014 Jun 15;189(12):1538-43. doi: 10.1164/rccm.201402-0342OC. PubMed PMID: 24871971; PubMed Central PMCID: PMC4226019.

Kurland G, Deterding RR, Hagood JS, Young LR, Brody AS, Castile RG, Dell S, Fan LL, Hamvas A, Hilman BC, Langston C, Nogee LM, Redding GJ; American Thoracic Society Committee on Childhood Interstitial Lung Disease (chILD) and the chILD Research Network. "An official American Thoracic Society clinical practice guideline: classification, evaluation, and management of childhood interstitial lung disease in infancy." Am J Respir Crit Care Med. 2013 Aug 1;188(3):376-94. doi: 10.1164/rccm.201305-0923ST. Review. PubMed PMID: 23905526; PubMed Central PMCID: PMC3778735.

Nogee, LM and Hamvas, A. The Past and Future of Genetics in Pulmonary Medicine – You Can Teach an Old Dog New Tricks. Pediatr Pulmonol, 55:1789-1793, 2020. PMID: 32533910

Wambach, JA and Nogee, LM. A step towards treating a lethal neonatal lung disease: STAT3 and alveolar capillary dysplasia. Am J Resp Crit Care Med, 200:961-2, 2019.

Nogee, LM. Genetic Causes of Surfactant Protein Abnormalities. Curr Opin Pediatrics, 31:330-9,2019.

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The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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