Skip Navigation

Find a Doctor

Find a Researcher

Researchers

Stuart Campbell Ray, M.D.

Photo of Dr. Stuart Campbell Ray, M.D.
  • Vice Chair of Medicine for Data Integrity and Analytics
  • Professor of Medicine
Male

Expertise

Chronic Viral Hepatitis, Hepatitis, HIV/AIDS, Infectious Disease, Internal Medicine

Research Interests

Hepatitis C immunology; Hepatitis C virology; Viral Evolution; HIV pathogenesis; Computational biology; NanoDiagnostics

Request an Appointment

Insurance Information

Maryland

410-583-2736
Request Appointment

Outside of Maryland

410-464-6641
Request Appointment

International Patients

+1-410-502-7683
Request Appointment

Locations

The Johns Hopkins Hospital

Appointment Phone: 410-583-2736
600 N. Wolfe Street
Nelson Building
Baltimore, MD 21287 map
Phone: 410-614-2891 | Fax: 443-769-1221

Background

Stuart C. Ray, MD, FACP, FIDSA serves as Vice Chair of Medicine for Data Integrity and Analytics and is a Professor in the Division of Infectious Diseases within the Department of Medicine, with secondary appointments in Viral Oncology and Health Sciences Informatics. He is Scientific Director of the JHU Laboratory for Integrated NanoDiagnostics, directs the virology laboratory and is a clinical investigator in the Center for Viral Hepatitis Research in the Division of Infectious Diseases. He is a faculty member of the Graduate Immunology program, the Graduate Pharmacology program, and of the Janeway Firm of the Osler Medical Service.

Dr. Ray received his M.D. from Vanderbilt University School of Medicine in 1990. After an internship and residency at Johns Hopkins Hospital, he continued there as an Assistant Chief of Service and fellow in Infectious Diseases. During his fellowship, he studied the immunology and sequence variation of HIV in the laboratory of Dr. Robert Bollinger. During that time, he developed an interest in HIV sequence variation during antiretroviral therapy in a productive collaboration with Dr. Robert Siliciano that continues to the present.

In 1997 Dr. Ray joined the Johns Hopkins faculty, and under the mentorship of Dr. David Thomas shifted his primary research focus to hepatitis C virus (HCV).  His laboratory work has focused on the sequence variation of HCV during acute and chronic infection, developing and applying computational and molecular biology tools to underlying mechanisms including stochastic variation, immune selection, and viral fitness. He continues to care for patients with HIV, HCV, and other infectious diseases.

...read more

Titles

  • Vice Chair of Medicine for Data Integrity and Analytics
  • Scientific Director, Laboratory for Integrated NanoDiagnostics
  • Professor of Medicine
  • Joint Appointment in Health Sciences Informatics
  • Professor of Oncology

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MD, Vanderbilt University School of Medicine (1990)

Residencies

  • Johns Hopkins University School of Medicine / Internal Medicine (1993)

Fellowships

  • Johns Hopkins University School of Medicine / Infectious Diseases (1997)

Board Certifications

  • American Board of Internal Medicine / Infectious Disease (1998)
  • American Board of Internal Medicine / Internal Medicine (1993)

Research & Publications

Research Summary

Dr. Ray's research focuses on innovative nanodiagnostics, with a long term interest in hepatitis C virus (HCV) sequence evolution and persistence. HCV affects more than 3 million people in the United States and nearly 200 million worldwide. Current treatment is highly effective but expensive, and most infected people are unaware of their infection. Thus, Dr. Ray remains dedicated to enhanced screening, access to care, and rational vaccine development for HCV.

Lab

Technology Expertise Keywords

nanodiagnostics; computational biology; virology; immunology

Selected Publications

View all on Pubmed

Wasilewski LN, El-Diwany R, Munshaw S, Snider AE, Brady JK, Osburn WO, Ray SC, Bailey JR. A Hepatitis C Virus Envelope Polymorphism Confers Resistance to Neutralization by Polyclonal Sera and Broadly Neutralizing Monoclonal Antibodies. Journal of Virology. 2016; 90(7):3773-82.

Bailey JR, Dowd KA, Snider AE, Osburn WO, Mehta SH, Kirk GD, Thomas DL, Ray SC. CD4+ T-Cell-Dependent Reduction in Hepatitis C Virus-Specific Neutralizing Antibody Responses After Coinfection With Human Immunodeficiency Virus. The Journal of Infectious Diseases. 2015; 212(6):914-23.

El-Diwany R, Wasilewski LN, Witwer KW, Bailey JR, Page K, Ray SC, Cox AL, Thomas DL, Balagopal A. Acute Hepatitis C Virus Infection Induces Consistent Changes in Circulating MicroRNAs That Are Associated with Nonlytic Hepatocyte Release. Journal of Virology. 2015; 89(18):9454-64.

Newman RM, Lamers SL, Weiner B, Ray SC, Colgrove RC, Diaz F, Jing L, Wang K, Saif S, Young S, Henn M, Laeyendecker O, Tobian AA, Cohen JI, Koelle DM, Quinn TC, Knipe DM. Genome Sequencing and Analysis of Lamers SL, Newman RM, Laeyendecker O, Tobian AA, Colgrove RC, Ray SC, Koelle DM, Cohen J, Knipe DM, Quinn TC. Geographically Diverse Clinical Isolates of Herpes Simplex Virus 2. Journal of Virology. 2015; 89(16):8219-32.

Global Diversity within and between Human Herpesvirus 1 and 2 Glycoproteins. Journal of Virology. 2015; 89(16):8206-18.

Bailey JR, Wasilewski LN, Snider AE, El-Diwany R, Osburn WO, Keck Z, Foung SK, Ray SC. Naturally selected hepatitis C virus polymorphisms confer broad neutralizing antibody resistance. The Journal of Clinical Iinvestigation. 2015; 125(1):437-47.

Graw F, Balagopal A, Kandathil AJ, Ray SC, Thomas DL, Ribeiro RM, Perelson AS. Inferring viral dynamics in chronically HCV infected patients from the spatial distribution of infected hepatocytes. PLoS Computational Biology. 2014; 10(11):e1003934.

Patents

Use of consensus sequence as vaccine antigen to enhance recognition of virulent viral variants
Patent # USPTO 8168771 | 05/01/2012

Synthetic hepatitis C genome and methods of making and use
Patent # USPTO 9512183

Synthetic representative HCV subtypes, including a 1a and 1b genome, dubbed Bole1a and Bole1b, are provided using an inventive method of Bayesian phylogenetic tree analysis, ancestral sequence reconstruction and covariance analysis. Bole1a branches centrally among 390 full-genome sequences used in its design, a carefully curated 143 sequence full-genome dataset, and separate genomic regions including an independent set of 214 E1E2 sequences from a Baltimore cohort. Bole1a is phylogenetically representative of widely circulating strains. Full genome non-synonymous diversity comparison and 9-mer peptide coverage analysis showed that Bole1a is able to provide more coverage (94% and 78% respectively) than any other sequence in the dataset including H77, a traditional reference sequence. Bole1a also provides unsurpassed epitope coverage when compared to all known T cell epitopes.

Contact for Research Inquiries

Center for Viral Hepatitis Research
855 N. Wolfe St, Rangos bldg
Baltimore, MD 21205 map

Academic Affiliations & Courses

Graduate Program Affiliation

Immunology, Pharmacology

Courses and Syllabi

  • Genes To Society 1 - Immunology (ME.800.639)
    Co-Director

Activities & Honors

Honors

  • Elected Fellow, Infectious Diseases Society of America, 2008
  • Elected member and JHU Institutional Representative, American Society of Clinical Investigation, 2009
  • Professors' Award for Excellence in Teaching, Basic and Clinical Sciences, Johns Hopkins University, 2012
  • Elected Fellow, American College of Physicians, 2016
  • Elected Member, Interurban Clinical Club, 2016

Memberships

  • American Association for the Study of Liver Disease
  • American College of Physicians
  • American Society for Microbiology
  • American Society for Virology
  • American Society of Clinical Investigation
  • European Association for the Study of the Liver
  • Infectious Diseases Society of America
  • International Society for Computational Biology
  • Society for Molecular Biology and Evolution
  • Society of Industrial and Applied Mathematics

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

  • ...Loading ratings...
  • ... 
  • ... 
  • ... 
  • ... 
  • ... 

Comments

Loading...
Is this you? Edit Profile
back to top button