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Brigitte Maria Ronnett, M.D.
Professor of Pathology
Research Interests: Gynecologic pathology; molecular diagnosis of molar pregnancy; pathology of mucinous ovarian neoplasm; clinicopathological characterization of gynecologic neoplasms ...read more
The Johns Hopkins Hospital
401 North Broadway
Pathology, Weinberg Building, Suite 2242
Baltimore, MD 21231-2410 map
Dr. Brigitte M. Ronnett is Professor of Pathology and Gynecology & Obstetrics at The Johns Hopkins University School of Medicine and Hospital, Baltimore, MD. She is a diagnostic pathologist and clinical researcher whose accomplishments in clinical service, education and research have established her as a nationally and internationally recognized expert in gynecologic pathology. Dr. Ronnett graduated from Northwestern University, Evanston, IL (B.A. chemistry, 1982). She received her medical degree from the University Of Chicago Pritzker School Of Medicine, Chicago, IL (M.D., 1986). She completed residency training in anatomic and clinical pathology at The Johns Hopkins Hospital, Baltimore, MD, (anatomic: 1986-1989; clinical: 1991-1993). She also completed a 1-year surgical pathology fellowship at Memorial Sloan-Kettering Cancer Center, New York, NY (1989-1990) and a 1-year surgical pathology fellowship/chief residency at The Johns Hopkins Hospital, Baltimore, MD (1990-1991). She then completed a 2-year subspecialty fellowship in gynecologic pathology at The Johns Hopkins Hospital, Baltimore, MD (1993-1995). She joined the faculty of the Department of Pathology at The Johns Hopkins Hospital in 1995 and achieved the rank of Full Professor in 2007. Her clinical efforts are focused on a large gynecologic pathology consultation practice at The Johns Hopkins Hospital. Her research efforts have focused on the following topics: 1. ovarian mucinous tumors (distinction of primary and metastatic mucinous tumors in the ovaries, the origin of pseudomyxoma peritonei in women), 2. uterine cervical and endometrial pathology (HPV-related cervical lesions, ancillary techniques for distinction of endocervical and endometrial adenocarcinomas and subtyping of endometrial adenocarcinomas), and 3. hydatidiform moles (ancillary techniques for refined diagnosis).
- Professor of Pathology
- Professor of Gynecology and Obstetrics
- MD; Medicine, The University of Chicago Pritzker School of Medicine (1986)
- Johns Hopkins University School of Medicine / Anatomic Pathology (1989)
- Johns Hopkins University School of Medicine / Pathology Laboratory Medicine (1993)
- Johns Hopkins University School of Medicine / Surgical Pathology (1990)
- Memorial Sloan-Kettering Cancer Center / Pathology (1990)
- Johns Hopkins University School of Medicine / Gynecologic Pathology (1995)
- American Board of Pathology / Anatomic Pathology (1991)
- American Board of Pathology / Clinical Pathology (1993)
Research & Publications
Dr. Ronnett is a diagnostic pathologist and clinical researcher whose accomplishments in clinical service, education, and research have established her as a nationally and internationally recognized expert in gynecologic pathology. As a clinical researcher, her work has addressed a wide variety of topics in gynecologic pathology. Within this specialty, her research efforts have focused on the following topics:
- Ovarian mucinous tumors, with emphasis on distinction of primary and metastatic mucinous tumors in the ovaries and the origin of pseudomyxoma peritonei in women.
- Uterine cervical and endometrial pathology, with emphasis on ancillary techniques for distinction of endocervical and endometrial adenocarcinomas and subtyping of endometrial adenocarcinomas.
- Utility of ancillary techniques for refined diagnosis of hydatidiform moles.
- Collaborative funded studies on HPV-related cervical/anogenital lesions, functioning as a nationally recognized expert for adjudicating anogenital biopsy diagnoses.
Studies on ovarian mucinous tumors have contributed to refined diagnosis of these tumors, clarification of their behavior and relationship to pseudomyxoma peritonei (PMP), and improved recognition of metastatic tumors that simulate primary ovarian tumors. Studies on hydatidiform moles have highlighted the persistent problem of imperfect diagnostic reproducibility, demonstrated the value of ancillary techniques (p57 immunohistochemistry and DNA genotyping) for refining diagnosis, and characterized interesting and unusual molar entities.
Selected PublicationsView all on Pubmed
Ronnett BM, Zahn CM, Kurman RJ, Kass ME, Sugarbaker PH, Shmookler BM. Disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis: a clinicopathologic analysis of 109 cases with emphasis on distinguishing pathologic features, site of origin, prognosis, and relationship to pseudomyxoma peritonei. Am J Surg Pathol 1995;19(12):1390-1408. PMID: 7503361
Ronnett BM, Kajdacsy-Balla A, Gilks CB, Merino MJ, Silva E, Werness BA, Young RH. Mucinous borderline ovarian tumors: points of general agreement and persistent controversies regarding nomenclature, diagnostic criteria, and behavior. Hum Pathol 2004;35(8):949-960. PMID: 15297962
Ronnett BM, DeScipio C, Murphy KM. Hydatidiform moles: ancillary techniques to refine diagnosis. Int J Gynecol Pathol 2011;30(2):101-116. PMID: 21293291
Ronnett BM. Endocervical adenocarcinoma: selected diagnostic challenges. Mod Pathol 2016;29(Suppl 1):S12-28. PMID: 26715171
Hui P, Buza N, Murphy KM, Ronnett BM. Hydatidiform moles: genetic basis and precision diagnosis. Ann Rev Pathol 2017;12:449-485. PMID: 28135560